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K. Schmalfuß Th. Sedlmayr A. J. Müller S. Danert H. Grimm R. Schick M. Klinkowski Alfred Lein I. Nover Fabig A. Rieth Rieger M. Gersch J. Schöneich Faust Böhme K. Zimmermann G. Sterba W. Kreil 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1963,33(5):226-232
Ohne Zusammenfassung 相似文献
43.
A. Lein M. Klinkowski F. Scholz Gottwalt Christian Hirsch Jörg Schöneich R. Schubert Paula Hertwig Schultze-Motel S. Danert Alfred Lein H. Stelter Otto Wettstein Friedrich Fabig H. Schumm Wuttky R. Schick H. -A. Freye F. Weiser 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1963,33(7):307-312
Ohne Zusammenfassung 相似文献
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Polyol Structure Influences Enzymatic Hydrolysis of Bio‐Based 2,5‐Furandicarboxylic Acid (FDCA) Polyesters
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Harald Staiger Otto Tschritter Jürgen Machann Claus Thamer Andreas Fritsche Elke Maerker Fritz Schick Hans‐Ulrich Hring Michael Stumvoll 《Obesity (Silver Spring, Md.)》2003,11(3):368-376
Objective: We investigated whether serum concentrations of adiponectin are determined by body fat distribution and compared the findings with leptin. Research Methods and Procedures: Serum concentrations of adiponectin and leptin were measured by radioimmunoassay (n = 394) and analyzed for correlation with sex, age, and body fat distribution, i.e., waist‐to‐hip ratio, waist and hip circumference, and subcutaneous adipose tissue area of the lower leg as assessed by magnetic resonance imaging. Results: After adjusting for sex and percentage of body fat, adiponectin was negatively (r = ?0.17, p < 0.001) and leptin was positively (r = 0.22, p < 0.001) correlated with waist‐to‐hip ratio. Leptin, but not adiponectin, correlated with both waist (r = 0.49, p < 0.001) and hip circumference (r = 0.46, p < 0.001). Furthermore, leptin, but not adiponectin, correlated with the proportion of subcutaneous fat of the lower leg cross‐sectional area (r = 0.37, p < 0.001). Discussion: These data suggest that both adipocytokines are associated with central body fat distribution, and serum adiponectin concentrations are determined predominantly by the visceral fat compartment. 相似文献
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The extracellular matrix component collagen type VI demonstrates potent growth-stimulatory effects and has been associated
with aggressive tumour growth. Although, juvenile angiofibromas (JAs) often exhibit an aggressive growth pattern, the collagen
type VI expression of this fibrovascular tumour has not been addressed so far. RT-PCR, Western blot analysis and immunohistochemistry
were used in this study to analyse collagen type VI, type VI collagen receptor subunits (integrin α1, α2, α10, α11 and β1)
and the type VI collagen receptor NG2 in JAs (N = 15) and nasal mucosa (NM, N = 8) samples. The mRNA expression of all three collagen type VI chains was found to be up-regulated significantly (P < 10−3–10−5, adjusted) in JAs compared to NM tissues. The Western blot analysis proved highly prominent collagen-type VI expression in
JAs. The ApoTome technique revealed strong collagen-type VI signals in tumour endothelium. NG2 (P < 10−3, adjusted) and α11-integrin (P = 0.04, adjusted) showed a significantly higher mRNA expression levels in JAs than in NM samples. NG2, α1-, α2- and β1-intergin
were located to tumour vessels, and additional stromal signals were observed for NG2 and α1-integrin in JAs. This study demonstrates
a prominent collagen-type VI expression in JAs. The collagen-type VI may exert an important growth stimulus in this tumour. 相似文献