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121.
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Marco Rosario Capodiferro Bethany Aram Alessandro Raveane Nicola Rambaldi Migliore Giulia Colombo Linda Ongaro Javier Rivera Tomás Mendizábal Iosvany Hernández-Mora Maribel Tribaldos Ugo Alessandro Perego Hongjie Li Christiana Lyn Scheib Alessandra Modi Alberto Gòmez-Carballa Viola Grugni Gianluca Lombardo Garrett Hellenthal Alessandro Achilli 《Cell》2021,184(7):1706-1723.e24
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Selpi Christopher H Bryant Graham JL Kemp Janeli Sarv Erik Kristiansson Per Sunnerhagen 《BMC bioinformatics》2009,10(1):451
Background
Some upstream open reading frames (uORFs) regulate gene expression (i.e., they are functional) and can play key roles in keeping organisms healthy. However, how uORFs are involved in gene regulation is not yet fully understood. In order to get a complete view of how uORFs are involved in gene regulation, it is expected that a large number of experimentally verified functional uORFs are needed. Unfortunately, wet-experiments to verify that uORFs are functional are expensive. 相似文献125.
126.
Duggan KC Hermanson DJ Musee J Prusakiewicz JJ Scheib JL Carter BD Banerjee S Oates JA Marnett LJ 《Nature chemical biology》2011,7(11):803-809
Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid and the endocannabinoids 2-arachidonoylglycerol and arachidonoylethanolamide. Evaluation of a series of COX-2 inhibitors revealed that many weak competitive inhibitors of arachidonic acid oxygenation are potent inhibitors of endocannabinoid oxygenation. (R) enantiomers of ibuprofen, naproxen and flurbiprofen, which are considered to be inactive as COX-2 inhibitors, are potent 'substrate-selective inhibitors' of endocannabinoid oxygenation. Crystal structures of the COX-2–(R)-naproxen and COX-2–(R)-flurbiprofen complexes verified this unexpected binding and defined the orientation of the (R) enantiomers relative to (S) enantiomers. (R)-Profens selectively inhibited endocannabinoid oxygenation by lipopolysaccharide-stimulated dorsal root ganglion (DRG) cells. Substrate-selective inhibition provides new tools for investigating the role of COX-2 in endocannabinoid oxygenation and a possible explanation for the ability of (R)-profens to maintain endocannabinoid tone in models of neuropathic pain. 相似文献
127.
In vivo expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors 下载免费PDF全文
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129.
Marija Cvijović Daniel Dalevi Elizabeth Bilsland Graham JL Kemp Per Sunnerhagen 《BMC bioinformatics》2007,8(1):295
Background
The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main ORF by interfering with translational reinitiation at the main start codon. uORFs also occur by chance in the genome, in which case they do not have a regulatory role. Since the sequence determinants for functional uORFs are not understood, it is difficult to discriminate functional from spurious uORFs by sequence analysis. 相似文献130.
Mari Järve Lehti Saag Christiana Lyn Scheib Ajai K. Pathak Francesco Montinaro Luca Pagani Rodrigo Flores Meriam Guellil Lauri Saag Kristiina Tambets Alena Kushniarevich Anu Solnik Liivi Varul Stanislav Zadnikov Oleg Petrauskas Maryana Avramenko Boris Magomedov Serghii Didenko Richard Villems 《Current biology : CB》2019,29(14):2430-2441.e10