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51.
Alaullah Sheikh Farhana Khanam Md. Abu Sayeed Taibur Rahman Marcin Pacek Yanhui Hu Andrea Rollins Md. Saruar Bhuiyan Sean Rollins Anuj Kalsy Mohammad Arifuzzaman Daniel T. Leung David A. Sarracino Bryan Krastins Richelle C. Charles Regina C. LaRocque Alejandro Cravioto Stephen B. Calderwood W. Abdullah Brooks Jason B. Harris Joshua LaBaer Firdausi Qadri Edward T. Ryan 《PLoS neglected tropical diseases》2011,5(6)
52.
Bisma Jan Rabea Parveen Sultan Zahiruddin Mohammad Umar Khan Sradhanjali Mohapatra Sayeed Ahmad 《Saudi Journal of Biological Sciences》2021,28(7):3909-3921
Mulberry is a fast growing deciduous plant found in wide variety of climatic, topographical and soil conditions, and is widely distributed from temperate to subtropical regions. Due to presence of valuable phytochemical constituents, mulberry as a whole plant has been utilized as a functional food since long time. Mulberry fruits are difficult to preserve as they have relatively high water content. Therefore for proper utilization, different value-added products like syrups, squashes, teas, pestil sand köme, pekmez (turkuish by-products), yogurts, jams, jellies, wines, vinegar, breads, biscuits, parathas, and many more are made. In overseas, these value-added products are commercially sold and easily available, though in India, this versatile medicinal plant is still missing its identity at commercial and industrial scale. Leaves of mulberry are economically viable due to their important role in the sericulture industry since ancient times. Mulberries or its extracts exhibit excellent anti-microbial, anti-hyperglycaemic, anti-hyperlipidemic, anti-inflammatory, anti-cancer effects and is used to combat different acute and chronic diseases. Different parts of Morus species like fruits, leaves, twigs, and bark exhibit strong anti-tyrosinase inhibition activity that makes it a suitable candidate in cosmetic industries as a whitening agent. The current review provides a comprehensive discussion concerning the phytochemical constituents, functionality and nutraceutical potential of mulberry and as a common ingredient in various cosmetic products. 相似文献
53.
54.
Rakhi B. Shah Jarrod S. Collier Vilayat A. Sayeed Arthur Bryant Muhammad J. Habib Mansoor A. Khan 《AAPS PharmSciTech》2010,11(3):1359-1367
Levothyroxine is a narrow therapeutic index, and to avoid adverse effect associated with under or excessive dosage, the dose
response is carefully titrated. The tablets are marketed with a score providing an option to split. However, there are no
systematic studies evaluating the effect of splitting on dose accuracy, and current study was undertaken to evaluate effects
of splitting and potential causes for uniformity failures by measuring assay and content uniformity in whole and split tablets.
Stability was evaluated by assaying drug for a period of 8 weeks. Effect of formulation factors on splittability was evaluated
by a systematic investigation of formulation factors by preparing levothyroxine tablets in house by varying the type of excipients
(binder, diluent, disintegrant, glidant) or by varying the processing factors (granulating liquid, mixing type, compression
pressure). The tablets were analyzed using novel analytical tool such as near infrared chemical imaging to visualize the distribution
of levothyroxine. Assay was not significantly different for whole versus split tablets irrespective of method of splitting (hand or splitter), and splitting also had no measurable impact on the
stability. Split tablets either by hand or splitter showed higher rate of content uniformity failures as compared to whole
tablets. Tablet splitter produced more fragmentation and, hence, more content uniformity and friability failures. Chemical
imaging data revealed that the distribution of levothyroxine was heterogeneous and was dependent on type of binder and the
process used in the manufacture of tablets. Splitting such tablets could prove detrimental if sub- or super-potency becomes
an issue. 相似文献
55.
Abhay Gupta Robert L. Hunt Rakhi B. Shah Vilayat A. Sayeed Mansoor A. Khan 《AAPS PharmSciTech》2009,10(2):495-499
The purpose of the work was to investigate correlation between disintegration and dissolution for immediate release tablets
containing a high solubility drug and to identify formulations where disintegration test, instead of the dissolution test,
may be used as the acceptance criteria based on International Conference on Harmonization Q6A guidelines. A statistical design
of experiments was used to study the effect of filler, binder, disintegrating agent, and tablet hardness on the disintegration
and dissolution of verapamil hydrochloride tablets. All formulation variables, i.e., filler, binder, and disintegrating agent,
were found to influence tablet dissolution and disintegration, with the filler and disintegrating agent exerting the most
significant influence. Slower dissolution was observed with increasing disintegration time when either the filler or the disintegrating
agent was kept constant. However, no direct corelationship was observed between the disintegration and dissolution across
all formulations due to the interactions between different formulation components. Although all tablets containing sodium
carboxymethyl cellulose as the disintegrating agent, disintegrated in less than 3 min, half of them failed to meet the US
Pharmacopeia 30 dissolution criteria for the verapamil hydrochloride tablets highlighting the dependence of dissolution process
on the formulation components other than the disintegrating agent. The results identified only one formulation as suitable
for using the disintegration test, instead of the dissolution test, as drug product acceptance criteria and highlight the
need for systematic studies before using the disintegration test, instead of the dissolution test as the drug acceptance criteria.
The opinions expressed in this work are only of authors and do not necessarily reflect the policy and statements of the FDA. 相似文献
56.
Fazal N Al-Ghoul WM Choudhry MA Sayeed MM 《American journal of physiology. Cell physiology》2001,281(4):C1310-C1317
The role of platelet-activating factor (PAF) inCa2+ signaling and Ca2+-related enhancement ofreactive oxygen intermediate (ROI) generation in neutrophils ofburn-injured rats was ascertained by evaluating the effect of treatmentof the rats with a PAF receptor antagonist. The treatment of rats withthe antagonist also allowed us to evaluate the role of PAF in thepriming of neutrophil ROI response with burn in vivo. A full skinthickness burn injury was produced in anesthetized rats by exposing30% of total body surface area to 98°C water for 10 s. Sham andburn rats were killed 1 day later, and their blood was collected toobtain neutrophils. Fluorescence-activated cell sorter analysis wasused to quantify ROI production by the neutrophils. Cytosolic-freeCa2+ concentration ([Ca2+]i)imaging technique was employed to measure neutrophil[Ca2+]i in individual cells andmicrofluorometry for the assessment of[Ca2+]i responses in suspensions ofneutrophils. There was an overt enhancement of ROI generation by burnrat neutrophils. ROI release was accompanied by a marked elevation of[Ca2+]i signaling. The treatment of rats withPAF receptor antagonist before burn prevented the upregulation of both[Ca2+]i and ROI generation in neutrophils.These studies indicate that enhanced ROI production in neutrophils inthe early stages after burn injury results from a PAF-mediated primingof the [Ca2+]i signaling pathways in vivo. 相似文献
57.
Sir O Fazal N Choudhry MA Gamelli RL Sayeed MM 《American journal of physiology. Regulatory, integrative and comparative physiology》2000,278(5):R1224-R1231
Cutaneous thermal injury increases intestinal mucosal permeability. The mechanisms of this functional disturbance are not fully understood. We investigated whether accumulation of neutrophils in the intestine contributes to the increase in mucosal permeability. Labeled and unlabeled lactulose and mannitol were infused into a segment of rat ileum or jejunum. Blood concentrations of [(3)H]lactulose and [(14)C]mannitol were measured after 30, 60, and 90 min. On day 1 postburn, lactulose permeability increased fourfold in the ileum and twofold in the jejunum compared with sham-burned rats; mannitol permeability increased twofold in the ileum and 1. 5-fold in the jejunum. A greater increase in permeability occurred on day 3 postburn in the ileum, but not in the jejunum. The depletion of neutrophils in burned rats prevented the increase in permeability in both segments on day 1 postburn. Histological studies of intestines from burned, with or without neutrophil depletion, and sham-burned rats showed similar morphology. However, numerous neutrophils were found in the extravascular compartment in day 1 postburn, but not in neutrophil-depleted and sham-burned rats. These findings support the concept that the burn-induced increase in mucosal permeability is produced during the accumulation of neutrophils in the intestine and can be abrogated by the depletion of neutrophils. 相似文献
58.
Zaid RB Nargis M Neelotpol S Sayeed MA Banu A Shurovi S Hassan KN Salimullah M Ali L Azad Khan AK 《Human biology; an international record of research》2007,79(3):363-368
The Marma, Tripura, and Chakma are tribal populations of South Asian countries such as Bangladesh. The populations are thought to be immigrants who started moving from their original home in the Far East toward the west and south. We randomly selected 80 Marma, 53 Tripura, and 43 Chakma to determine acetylation capacity and acetylator phenotype. The mean acetylation capacities were 63% in the Marma, 65% in the Tripura, and 70% in the Chakma. The acetylator phenotype was bimodally distributed as fast and slow acetylator. The frequencies of fast acetylator were 83% in the Marma, 89% in the Tripura, and 88% in the Chakma. According to acetylation capacity, the tribes are different from the founder nontribal populations of Bangladesh. They identify themselves as having a separate single population origin. The frequency of fast acetylator predicted served as the acetylator status of the Far East Asian population. The segregation of populations by acetylator phenotype on geographic longitude might be appropriate for geonational identification of Asian populations. 相似文献
59.
Sequencing and diversity analyses reveal extensive similarities between some epsilon-toxin-encoding plasmids and the pCPF5603 Clostridium perfringens enterotoxin plasmid 下载免费PDF全文
Clostridium perfringens type B and D isolates produce epsilon-toxin, the third most potent clostridial toxin. The epsilon-toxin gene (etx) is plasmid borne in type D isolates, but etx genetics have been poorly studied in type B isolates. This study reports the first sequencing of any etx plasmid, i.e., pCP8533etx, from type B strain NCTC8533. This etx plasmid is 64.7 kb, carries tcp conjugative transfer genes, and encodes additional potential virulence factors including beta2-toxin, sortase, and collagen adhesin but not beta-toxin. Interestingly, nearly 80% of pCP8533etx open reading frames (ORFs) are also present on pCPF5603, an enterotoxin-encoding plasmid from type A isolate F5603. Pulsed-field gel electrophoresis and overlapping PCR indicated that a pCP8533etx-like etx plasmid is also present in most, if not all, other type B isolates and some beta2-toxin-positive, cpe-negative type D isolates, while other type D isolates carry different etx plasmids. Sequences upstream of the etx gene vary between type B isolates and some type D isolates that do not carry a pCP8533etx-like etx plasmid. However, nearly all type B and D isolates have an etx locus with an upstream IS1151, and those etx loci typically reside near a dcm ORF. These results suggest that pCPF5603 and pCP8533etx evolved from insertion of mobile genetic elements carrying enterotoxin or etx genes, respectively, onto a common progenitor plasmid. 相似文献
60.