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141.
Staphylococcus sp. strain S3/C desulfurized dibenzothiophene/n-hexadecane (3 mg ml–1) in a hydrocarbon aqueous biphasic culture. The resting cells decreased the sulfur content of the hydrocarbon phase by 57% at 2.2 mg l–1 h–1 in the absence of any additional carbon and sulfur source. 相似文献
142.
143.
Two spontaneous triploid plants of Trigonella corniculata (3n=24) were observed in a population raised from irradiated seeds. Up to seven trivalents per cell were observed. One of the plants appeared to be a double translocation heterozygote involving two non-homologous chromosomes, and therefore could form a quadrivalent, a ring trivalent and bivalents without corresponding univalents. 相似文献
144.
145.
Immobilization of whole cells in a membraneous form 总被引:3,自引:0,他引:3
146.
Nayden G. Naydenov Supriya Joshi Alex Feygin Siddharth Saini Larisa Litovchick 《Cell cycle (Georgetown, Tex.)》2018,17(14):1812-1831
Vesicle trafficking regulates epithelial cell migration by remodeling matrix adhesions and delivering signaling molecules to the migrating leading edge. Membrane fusion, which is driven by soluble N-ethylmaleimide-sensitive factor associated receptor (SNARE) proteins, is an essential step of vesicle trafficking. Mammalian SNAREs represent a large group of proteins, but few have been implicated in the regulation of cell migration. Ykt6 is a unique SNARE existing in equilibrium between active membrane-bound and inactive cytoplasmic pools, and mediating vesicle trafficking between different intracellular compartments. The biological functions of this protein remain poorly understood. In the present study, we found that Ykt6 acts as a negative regulator of migration and invasion of human prostate epithelial cells. Furthermore, Ykt6 regulates the integrity of epithelial adherens and tight junctions. The observed anti-migratory activity of Ykt6 is mediated by a unique mechanism involving the expressional upregulation of microRNA 145, which selectively decreases the cellular level of Junctional Adhesion Molecule (JAM) A. This decreased JAM-A expression limits the activity of Rap1 and Rac1 small GTPases, thereby attenuating cell spreading and motility. The described novel functions of Ykt6 could be essential for the regulation of epithelial barriers, epithelial repair, and metastatic dissemination of cancer cells. 相似文献
147.
148.
Tanveer Ahmad Wani Abdus Samad Monika Tandon Gurpreet S. Saini P. L. Sharma K. K. Pillai 《AAPS PharmSciTech》2010,11(1):425-432
In this open-label, balanced, randomized, placebo-controlled, parallel study, healthy male volunteers were randomly divided
into two groups. Each group received either a single oral dose of rosuvastatin 20 mg or placebo. Estimations were done at
predose on day 1 of dosing (baseline) and 24 h postdose after days 7 and 14. Serum cortisol and serum lipid levels were estimated
using enzyme-linked immunosorbent assay kits and serum mevalonic acid (MVA) levels were measured using validated liquid chromatography–tandem
mass spectrometry method. Rosuvastatin produced a statistically significant (P < 0.05) decrease in total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and
triglycerides. However, the increase in high-density lipoprotein cholesterol and decrease in cortisol and MVA were not statistically
significant when compared to the placebo-treated group. The study showed that rosuvastatin at a dose of 20 mg/day for a period
of 14 days was very potent as cholesterol-lowering agent, without any significant change in serum cortisol level in the healthy
Indian male population. 相似文献
149.
150.
In germinating lupin cotyledons, there was a rapid depletion of raffinose series oligosaccharides, a temporary increase in sucrose and constant low levels of reducing monosaccharides. The major polysaccharide fraction was extracted with hot NH4 oxalate—EDTA solution and had the constitution of intercellular/cell wall polysaccharide. GLC examination of component sugars showed that as cotyledons expanded this fraction was depleted and that there was selective hydrolysis of arabinose and galactose, so that the uronic acid proportion increased. Gel and DEAE-cellulose chromatography showed that this fraction became more heterogeneous. The neutral and acidic fractions were separated and the component sugars, viscosities, gel chromatographic behaviour and sedimentation constants of these determined. The results indicated that in the later phase of plant cell wall expansion in germinating lupin cotyledons the arabinogalactan side chains of the pectic polysaccharide fraction are selectively hydrolysed leaving a primary wall with a high uronic acid content. 相似文献