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排序方式: 共有2349条查询结果,搜索用时 15 毫秒
251.
Pyne DB Duthie GM Saunders PU Petersen CA Portus MR 《Journal of strength and conditioning research / National Strength & Conditioning Association》2006,20(3):620-626
The aim of this study was to characterize relationships between anthropometric and isoinertial strength characteristics and bowling speed in junior and senior cricket fast bowlers. Subjects were first-class senior (n = 24; mean +/- SD age = 23.9 +/- 4.8 years, height = 187.4 +/- 4.8 cm, mass = 87.8 +/- 8.4 kg) and junior representative (n = 48; mean +/- SD age = 14.8 +/- 1.3 years, height = 175.7 +/- 9.8 cm, mass = 65.8 +/- 12.9 kg) male fast bowlers. A full anthropometric profile, upper- and lower-body isoinertial strength tests, and peak bowling speed (Vpeak) were assessed on the same day. The senior bowlers had a substantially faster Vpeak (126.7 km.h(-1)) than the juniors (99.6 km.h(-1)), a larger estimated muscle mass (seniors 40.0 +/- 3.9 kg, juniors 28.3 +/- 5.6 kg), and a greater bench press throw and deltoid throw (all p < 0.01). The best multiple predictors of Vpeak for the junior bowlers were the static jump, bench throw, body mass, percentage muscle mass, and height (multiple-correlation r = 0.86). For the senior bowlers, static jump and arm length correlated positively with Vpeak (multiple-correlation r = 0.74). The 1-legged countermovement jump was negatively correlated with Vpeak in both groups. We conclude that differences in Vpeak between junior and senior bowlers relate primarily to body mass and upper-body strength. However, lower body strength is a more important contributor to Vpeak in senior bowlers. 相似文献
252.
Saunders PU Telford RD Pyne DB Peltola EM Cunningham RB Gore CJ Hawley JA 《Journal of strength and conditioning research / National Strength & Conditioning Association》2006,20(4):947-954
Fifteen highly trained distance runners VO(2)max 71.1 +/- 6.0 ml.min(-1).kg(-1), mean +/- SD) were randomly assigned to a plyometric training (PLY; n = 7) or control (CON; n = 8) group. In addition to their normal training, the PLY group undertook 3 x 30 minutes PLY sessions per week for 9 weeks. Running economy (RE) was assessed during 3 x 4 minute treadmill runs (14, 16, and 18 km.h(-1)), followed by an incremental test to measure VO(2)max. Muscle power characteristics were assessed on a portable, unidirectional ground reaction force plate. Compared with CON, PLY improved RE at 18 km.h(-1) (4.1%, p = 0.02), but not at 14 or 16 km.h(-1). This was accompanied by trends for increased average power during a 5-jump plyometric test (15%, p = 0.11), a shorter time to reach maximal dynamic strength during a strength quality assessment test (14%, p = 0.09), and a lower VO(2)-speed slope (14%, p = 0.12) after 9 weeks of PLY. There were no significant differences in cardiorespiratory measures or VO(2)max as a result of PLY. In a group of highly-trained distance runners, 9 weeks of PLY improved RE, with likely mechanisms residing in the muscle, or alternatively by improving running mechanics. 相似文献
253.
Seven top amateur or professional skateboarders (BW=713 N+/-83 N) performed Ollie maneuvers onto and off an elevated wooden platform (45.7 cm high). We recorded ground reaction force (GRF) data for three Ollie Up (OU) and Ollie Down (OD) trials per participant. The vertical GRF (VGRF) during the OU has a characteristic propulsive peak (M=2.22 body weight [BW]+/-0.22) resulting from rapidly rotating the tail of the board into the ground to propel the skater and board up and forward. The anterior-posterior (A-P) GRF also shows a pronounced peak (M=0.05+/-0.01 BW) corresponding with this propulsive VGRF peak. The initial phase of landing in the OD shows an impact peak in VGRF rising during the first 30 to 80 ms to a mean of 4.74+/-0.46 BW. These impact peaks are higher than expected given the relatively short drop of 45.7 cm and crouched body position. But we observed that our participants intentionally affected a firm landing to stabilize the landing position; and the Ollie off the platform raised the center of mass, also contributing to higher forces. 相似文献
254.
Martin ER Gilbert JR Lai EH Riley J Rogala AR Slotterbeck BD Sipe CA Grubber JM Warren LL Conneally PM Saunders AM Schmechel DE Purvis I Pericak-Vance MA Roses AD Vance JM 《Genomics》2000,63(1):7-12
The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodology, we identified 10 SNPs in the region immediately surrounding the apolipoprotein E locus (APOE), an established susceptibility gene for Alzheimer disease. Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE. 相似文献
255.
Suzanne S. Teuber Robert L. Saunders Georges M. Halpern Robert F. Brucker Victor Conte Brian D. Goldman Edward E. Winger W. Graham Wood M. Eric Gershwin 《Biological trace element research》1995,48(2):121-130
The metatolic fate of silicone gel leaked from an intact or ruptured prosthesis is unknown. In this study, serum was blindly
assayed by inductively coupled plasma atomic emission spectroscopy (ICP-AES) for elemental silicon in 72 women with silicone
gel breast implants and 55 control women (mean age 48 yr, both groups). Blood was drawn and processed using silicon-free materials.
The mean silicon level in controls was 0.13±0.07 mg/L (range 0.06–0.35 mg/L), whereas in implant patients, the mean was significantly
higher at 0.28±0.22 mg/L (range 0.06–0.87 mg/L) (P<0.01, Student'st-test with correction for unequal variances). Using the mean of the control group +2 SD as a cutoff for normal range (0.27
mg/L), 25/72 (34.7%) implant patients exceeded this value, compared with 2/55 (3.6%) controls. There was no significant correlation
between past rupture of one or both implants, current rupture at the time of the blood draw, or the number of years with implants
and silicon levels. The results suggest that serum silicon levels are elevated in many women with silicone gel breast implants.
The chemical species involved and kinetics of this elevation remain to be determined. 相似文献
256.
Study of the posttranslational modification of methionine to its sulfoxide has been receiving increasing attention because of its implication in regulation of protein activity, but techniques for the detection of this modification remain limited. In particular, there has been no method to detect the oxidation of methionine on polyacrylamide gels. Here we demonstrate that alkylation of methionine introduces a charge change that shifts the mobility of the protein on an acidic gel relative to the alkylation-resistant sulfoxide form. 相似文献
257.
258.
The chimeric herpes simplex viruses (HSV) are Δγ134.5 vectors encoding the human cytomegalovirus (HCMV) IRS1 or TRS1 genes. They are capable of late viral protein synthesis and are superior to Δγ134.5 HSVs in oncolytic activity. The interferon (IFN) response limits efficient HSV gene expression and replication. HCMV TRS1 and IRS1 restore one γ134.5 gene function: evasion of IFN-inducible protein kinase R, allowing late viral protein synthesis. Here we show that, unlike wild-type HSV, the chimeric HSV do not restore another γ134.5 function, the suppression of early IFN signaling mediated by IFN regulatory factor 3 (IRF3). 相似文献
259.
Röring M Herr R Fiala GJ Heilmann K Braun S Eisenhardt AE Halbach S Capper D von Deimling A Schamel WW Saunders DN Brummer T 《The EMBO journal》2012,31(11):2629-2647
The dimerisation of Raf kinases involves a central cluster within the kinase domain, the dimer interface (DIF). Yet, the importance of the DIF for the signalling potential of wild-type B-Raf (B-Raf(wt)) and its oncogenic counterparts remains unknown. Here, we show that the DIF plays a pivotal role for the activity of B-Raf(wt) and several of its gain-of-function (g-o-f) mutants. In contrast, the B-Raf(V600E), B-Raf(insT) and B-Raf(G469A) oncoproteins are remarkably resistant to mutations in the DIF. However, compared with B-Raf(wt), B-Raf(V600E) displays extended protomer contacts, increased homodimerisation and incorporation into larger protein complexes. In contrast, B-Raf(wt) and Raf-1(wt) mediated signalling triggered by oncogenic Ras as well as the paradoxical activation of Raf-1 by kinase-inactivated B-Raf require an intact DIF. Surprisingly, the B-Raf DIF is not required for dimerisation between Raf-1 and B-Raf, which was inactivated by the D594A mutation, sorafenib or PLX4720. This suggests that paradoxical MEK/ERK activation represents a two-step mechanism consisting of dimerisation and DIF-dependent transactivation. Our data further implicate the Raf DIF as a potential target against Ras-driven Raf-mediated (paradoxical) ERK activation. 相似文献
260.
Shipovskov S Saunders AM Nielsen JS Hansen MH Gothelf KV Ferapontova EE 《Biosensors & bioelectronics》2012,37(1):99-106
Attomole (10(-18)mol) levels of RNA and DNA isolated from beer spoilage bacterial cells Lactobacillus brevis have been detected by the electrochemical sandwich DNA hybridization assay exploiting enzymatic activity of lipase. DNA sequences specific exclusively to L. brevis DNA and RNA were selected and used for probe and target DNA design. The assay employs magnetic beads (MB) modified with a capture DNA sequence and a reporter DNA probe labeled with the enzyme, both made to be highly specific for L. brevis DNA. Lipase-labeled DNAs captured on MBs in the sandwich assay were collected on gold electrodes modified with a ferrocene (Fc)-terminated SAM formed by aliphatic esters. Lipase hydrolysis of the ester bond released a fraction of the Fc redox active groups from the electrode surface, decreasing the electrochemical signal from the surface-confined Fc. The assay, shown to be efficient for analysis of short synthetic DNA sequences, was ineffective with genomic double stranded bacterial DNA, but it allowed down to 16 amole detection of 1563 nts long RNA, isolated from bacterial ribosomes without the need for PCR amplification, and single DNA strands produced from ribosomal RNA. No interference from E. coli RNA was registered. The assay allowed analysis of 400 L. brevis cells isolated from 1L of beer, which fits the "alarm signal" range (from 1 to 100 cells per 100mL). 相似文献