CONGESTIVE HEART FAILURE IN INFANTS AND CHILDREN

Congestive failure in infants and children is not uncommon and may be present in a varying number of conditions, particularly in certain types of congenital heart disease. Its recognition and proper treatment are usually followed by improvement, except in those instances where the failure is associated with a lesion incompatible with life. The essentials of treatment are: Treatment of the underlying cause, administration of a digitalis preparation, low salt diet, diuretics, rest and sedation, oxygen, adequate diet and, in rare instances, the use of steroids.     

An Inexpensive Inverted Microscope System

An inexpensive and easily constructable inverted microscope system is described in detail. Its multiple experimental usefulness in many branches of biology is mentioned.     

Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors

As a part of our efforts to identify potent inhibitors of farnesyltransferase (FTase), modification of the structure of tipifarnib through structure-based design was undertaken by replacing the 2-quinolones with 4-quinolones and pyridones, and subsequent relocation of the D-ring to the N-methyl group on the imidazole ring. This study has yielded a novel series of potent and selective FTase inhibitors. The X-ray structure of tipifarnib (1) in complex with FTase was described.