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261.
262.
Satyanarayana Rentala Sudhakar Konada Ramakrishna Chintala Lakshmi Narasu Mangamoori Suryanarayana Murthy Upadhyayula Sarva Mangala Dhurjeti 《Bioinformation》2013,9(14):721-724
Vitamin C, Vitamin E, scopoletin and damnacanthal are the major constituents of Noni (Morinda citrifolia). These compounds are
known to have good medicinal properties and they are known to act as antioxidants. Loss of vision in elderly is due to opaqueness
of the lens proteins such as gamma-D-crystallin during oxidative stress conditions. Therefore, it is of importance to find the
potential interaction of Vitamin C, Vitamin E, Scopoletin and Damnacanthal with the lens protein gamma-D-crystallin. Hence, their
physical binding to gamma-D crystallin (PDB ID: 2G98) was evaluated using molecular and structural docking procedures. Results
show the potential binding of all the above anti-oxidants to gamma-D-crystalline with equal affinity. Thus, the role of cumulative
anti-oxidant effect in Noni fruit juice through their potential yet predicted interaction with the lens protein gamma-D-crystallin is
implied for cataract treatment. 相似文献
263.
Lambertus Dorland Johannis P. Kamerling Johannes F.G. Vliegenthart Mallur N. Satyanarayana 《Carbohydrate research》1977,54(2):275-284
The structures of naturally occurring and enzymically synthesized oligosaccharides, consisting of fructose and glucose residues and having d.p. 3–8, in the stem of Agave vera cruz have been investigated by using methylation analysis, mass spectrometry, and p.m.r. spectroscopy. The naturally occurring trisaccharides were identified as 1-kestose and neokestose, and the tetrasaccharides as nystose and at least one other related to neokestose. The higher fractions consist of mixtures of (branched) oligosaccharides related to 1-kestose, neokestose, or 6-kestose as basic structures. The enzymically synthesized trisaccharide was identified as 1-kestose, and the tetrasaccharides as nystose. The higher fractions consist of mixtures of linear oligosaccharides related to 1-kestose and neokestose. 相似文献
264.
Sachdeva KS Satyanarayana S Dewan PK Nair SA Reddy R Kundu D Chadha SS Venkatachalaiah AK Parmar M Chauhan LS 《PloS one》2011,6(7):e22061
Background
In 2009, nearly half (289,756) of global re-treatment TB notifications are from India; no nationally-representative data on the source of previous treatment was available to inform strategies for improvement of initial TB treatment outcome.Objectives
To assess the source of previous treatment for re-treatment TB patients registered under India''s Revised National TB control Programme (RNTCP).Methodology
A nationally-representative cross sectional study was conducted in a sample of 36 randomly-selected districts. All consecutively registered retreatment TB patients during a defined 15-day period in these 36 districts were contacted and the information on the source of previous treatment sought.Results
Data was collected from all 1712 retreatment TB patients registered in the identified districts during the study period. The data includes information on 595 ‘relapse’ cases, 105 ‘failure’ cases, 437 ‘treatment after default (TAD)’ cases and 575 ‘re-treatment others’ cases. The source of most recent previous anti-tuberculosis therapy for 754 [44% (95% CI, 38.2%–49.9%)] of the re-treatment TB patients was from providers outside the TB control programme. A higher proportion of patients registered as TAD (64%) and ‘retreatment others’ (59%) were likely to be treated outside the National Programme, when compared to the proportion among ‘relapse’ (22%) or ‘failure’ (6%). Extrapolated to national registration, of the 292,972 re-treatment registrations in 2010, 128,907 patients would have been most recently treated outside the national programme.Conclusions
Nearly half of the re-treatment cases registered with the national programme were most recently treated outside the programme setting. Enhanced efforts towards extending treatment support and supervision to patients treated by private sector treatment providers are urgently required to improve the quality of treatment and reduce the numbers of patients with recurrent disease. In addition, reasons for the large number of recurrent TB cases from those already treated by the national programme require urgent detailed investigation. 相似文献265.
Chadha SS Sharath BN Reddy K Jaju J Vishnu PH Rao S Parmar M Satyanarayana S Sachdeva KS Wilson N Harries AD 《PloS one》2011,6(11):e26659
Background
Revised National TB Control Programme (RNTCP), Andhra Pradesh, India. There is limited information on whether MDR-TB suspects are identified, undergo diagnostic assessment and are initiated on treatment according to the programme guidelines.Objectives
To assess i) using the programme definition, the number and proportion of MDR-TB suspects in a large cohort of TB patients on first-line treatment under RNTCP ii) the proportion of these MDR-TB suspects who underwent diagnosis for MDR-TB and iii) the number and proportion of those diagnosed as MDR-TB who were successfully initiated on treatment.Methods
A retrospective cohort analysis, by reviewing RNTCP records and reports, was conducted in four districts of Andhra Pradesh, India, among patients registered for first line treatment during October 2008 to December 2009.Results
Among 23,999 TB patients registered for treatment there were 559 (2%) MDR-TB suspects (according to programme definition) of which 307 (55%) underwent diagnosis and amongst these 169 (55%) were found to be MDR-TB. Of the MDR-TB patients, 112 (66%) were successfully initiated on treatment. Amongst those eligible for MDR-TB services, significant proportions are lost during the diagnostic and treatment initiation pathway due to a variety of operational challenges. The programme needs to urgently address these challenges for effective delivery and utilisation of the MDR-TB services. 相似文献266.
Shanta Achanta Jyoti Jaju Ajay M. V. Kumar Sharath Burugina Nagaraja Srinivas Rao Motta Shamrao Sasidhar Kumar Bandi Ashok Kumar Srinath Satyanarayana Anthony David Harries Sreenivas Achutan Nair Puneet K. Dewan 《PloS one》2013,8(8)
Setting
Private medical practitioners in Visakhapatnam district, Andhra Pradesh, India.Objectives
To evaluate self-reported TB diagnostic and treatment practices amongst private medical practitioners against benchmark practices articulated in the International Standards of Tuberculosis Care (ISTC), and factors associated with compliance with ISTC.Design
Cross- sectional survey using semi-structured interviews.Results
Of 296 randomly selected private practitioners, 201 (68%) were assessed for compliance to ISTC diagnostic and treatment standards in TB management. Only 11 (6%) followed a combination of 6 diagnostic standards together and only 1 followed a combination of all seven treatment standards together. There were 28 (14%) private practitioners who complied with a combination of three core ISTC (cough for tuberculosis suspects, sputum smear examination and use of standardized treatment). Higher ISTC compliance was associated with caring for more than 20 TB patients annually, prior sensitization to TB control guidelines, and practice of alternate systems of medicine.Conclusion
Few private practitioners in Visakhapatnam, India reported TB diagnostic and treatment practices that met ISTC. Better engagement of the private sector is urgently required to improve TB management practices and to prevent diagnostic delay and drug resistance. 相似文献267.
Sokhan Khann Eang Tan Mao Yadav Prasad Rajendra Srinath Satyanarayana Sharath Burugina Nagaraja Ajay M. V. Kumar 《PloS one》2013,8(4)
Setting
National Tuberculosis Programme, Cambodia.Objective
In a cohort of TB patients, to ascertain the proportion of patients who fulfil the criteria for presumptive MDR-TB, assess whether they underwent investigation for MDR-TB, and the results of the culture and drug susceptibility testing (DST).Methods
A cross sectional record review of TB patients registered for treatment between July-December 2011.Results
Of 19,236 TB patients registered, 409 (2%) fulfilled the criteria of presumptive MDR-TB; of these, 187 (46%) were examined for culture. This proportion was higher among relapse, failure, return after default (RAD) and non-converters at 3 months of new smear positive TB patients (>60%) as compared to non-converters at 2 months of new TB cases (<20%). Nearly two thirds (n = 113) of the samples were culture positive; of these, three-fourth (n = 85) grew Mycobacterium tuberculosis complex (MTBc) and one-fourth (n = 28) grew non-tuberculous Mycobacteria. DST results were available for 96% of the MTBc isolates. Overall, 21 patients were diagnosed as MDR-TB (all diagnosed among retreatment TB cases and none from non-converters) and all of them were initiated on MDR-TB treatment.Conclusion
There is a need to strengthen mechanisms for linking patients with presumptive MDR-TB to culture centers. The policy of testing non-converters for culture and DST needs to be reviewed. 相似文献268.
Satyanarayana Rentala Ramakrishna Chintala Manohar Guda Madhuri Chintala Aruna Lakshmi Komarraju Lakshmi Narasu Mangamoori 《Biochemical and biophysical research communications》2013
Prostate cancer has become a global health concern and is one of the leading causes of cancer death of men after lung and gastric cancers. It has been suggested that the 3-hydroxy-3-methyl-glutarylcoenzyme-CoA (HMG-CoA) reductase inhibitor atorvastatin shows anticancer activity in prostate cancer cell lines. To this end, we analyzed the influence of atorvastatin on the cell adhesion and differentiation of CD133+CD44+ cells derived from prostate cancer biopsies and peripheral blood. CD133+CD44+ cells were treated with atorvastatin (16–64 μM) for different time periods. Cell adhesion to endothelial cell monolayers and differentiation into prostate cancer cells were evaluated. α1, β1 and α2β1 integrins adhesion receptors and the downstream target of atorvastatin Rho-dependent kinase (ROCK) and focal adhesion kinase (FAK) were analyzed by Western blot. Further blocking studies with the ROCK inhibitor H1152, anti-FAK antibody and anti-integrin α1 and β1 antibodies were carried out. Atorvastatin treatment inhibited dose-dependently cell attachment to endothelium and differentiation. The inhibitory effect of atorvastatin on cell adhesion was associated with decreased expression of integrins α1 and β1 and phosphorylated MYPT1 and FAK. Furthermore, atorvastatin strongly reduced ROCK1 and FAK mediated differentiation of CD133+CD44+ cells, which was confirmed by antibody treatment. Atorvastatin modified the expression of cell adhesion molecules and differentiation markers. These beneficial effects of atorvastatin may be mediated by ROCK and FAK signaling pathway. The data presented may point to novel treatment options for prostate cancer. 相似文献
269.
Veerabrahmam Alugolu Satyanarayana Rentala Aruna Lakshmi Komarraju Uma Devi Parimi 《Bioinformation》2013,9(7):334-338
Piperine, a major constituent of Piper nigrum (Black pepper), is one of the well known components in many Ayurvedic
formulations. Piperine is most studied bioenhancer because it inhibits drug metabolizing enzymes in rodents and increases plasma
concentrations of several drugs, including P-glycoprotein substrates. However, there areno evidences on piperine-iron conjugate to
inhibit human CYP450 3A4. We therefore investigated the influence of piperine-Fe conjugate to study the metabolism of iron with
CYP450 3A4. Our in silico results showed that Piperine when conjugated with iron, inhibited activity of CYP450 3A4. This
improved the binding of piperine-Fe conjugate with CYP450 3A4 and increased bioavailability. 相似文献