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排序方式: 共有408条查询结果,搜索用时 62 毫秒
401.
Harikesh S. Wong Valentin Jaumouillé Bryan Heit Sasha A. Doodnauth Sajedabanu Patel Yi-Wei Huang Sergio Grinstein Lisa A. Robinson 《Molecular biology of the cell》2014,25(24):3884-3899
CX3CL1 is a unique chemokine that acts both as a transmembrane endothelial adhesion molecule and, upon proteolytic cleavage, a soluble chemoattractant for circulating leukocytes. The constitutive release of soluble CX3CL1 requires the interaction of its transmembrane species with the integral membrane metalloprotease ADAM10, yet the mechanisms governing this process remain elusive. Using single-particle tracking and subdiffraction imaging, we studied how ADAM10 interacts with CX3CL1. We observed that the majority of cell surface CX3CL1 diffused within restricted confinement regions structured by the cortical actin cytoskeleton. These confinement regions sequestered CX3CL1 from ADAM10, precluding their association. Disruption of the actin cytoskeleton reduced CX3CL1 confinement and increased CX3CL1–ADAM10 interactions, promoting the release of soluble chemokine. Our results demonstrate a novel role for the cytoskeleton in limiting membrane protein proteolysis, thereby regulating both cell surface levels and the release of soluble ligand. 相似文献
402.
Here we provide a biologically relevant proof of the well‐known result from economics and statistical decision theory that having more information never reduces the expected payoff to a decision‐making agent. We then go on to illustrate this with an ecologically motivated example based on a model of growth under uncertain predation risk. Throughout we use the central result that the fitness (reproductive) value of information can never be negative to highlight conceptual inconsistencies in the ecological literature on information use. 相似文献
403.
The R package monitoR contains tools for managing an acoustic-monitoring program including survey metadata, template creation and manipulation, automated detection and results management. These tools are scalable for use with small projects as well as larger long-term projects and those with expansive spatial extents. Here, we describe typical workflow when using the tools in monitoR. Typical workflow utilizes a generic sequence of functions, with the option for either binary point matching or spectrogram cross-correlation detectors. 相似文献
404.
Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury
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405.
406.
Mark Westoby Daniel Aagren Nielsen Michael R. Gillings Elena Litchman Joshua S. Madin Ian T. Paulsen Sasha G. Tetu 《Ecology and evolution》2021,11(9):3956
Among bacteria and archaea, maximum relative growth rate, cell diameter, and genome size are widely regarded as important influences on ecological strategy. Via the most extensive data compilation so far for these traits across all clades and habitats, we ask whether they are correlated and if so how. Overall, we found little correlation among them, indicating they should be considered as independent dimensions of ecological variation. Nor was correlation evident within particular habitat types. A weak nonlinearity (6% of variance) was found whereby high maximum growth rates (temperature‐adjusted) tended to occur in the midrange of cell diameters. Species identified in the literature as oligotrophs or copiotrophs were clearly separated on the dimension of maximum growth rate, but not on the dimensions of genome size or cell diameter. 相似文献
407.
Sasha Koulish 《Journal of experimental marine biology and ecology》1976,23(2):155-170
The layer of cells immediately underlying the midgut in the Balanidae contains unusual structural features which distinguish it from the remaining parenchyma. The cells, in general, are expanded at their distal end (away from the midgut), narrow at the proximal end (towards the midgut) and are referred to in this study as morphologically polarized cells. The narrow portion contains numerous aligned microtubules which pass through holes in perpendicularly oriented membranous sacs. This portion of the cell continues toward the midgut between layers of muscle across hemolymphatic space and terminates within infolding at the basal end of the intestinal epithelial cells. The distal, expanded portion of the cell contains many dense, lamellar bodies. S.E.M. X-ray spectra of the lamellar bodies show predominant peaks for zinc and phosphorus. Some functional implications of the organization and location of these cells are discussed. 相似文献
408.
Information is characterized as the reduction of uncertainty and by a change in the state of a receiving organism. Thus, organisms can acquire information about their environment that reduces uncertainty and increases their likelihood of choosing a best‐matching strategy. We define the ecology of information as the study of how organisms acquire and use information in decision‐making and its significance for populations, communities, landscapes and ecosystems. As a whole, it encompasses the reception and processing of information, decision‐making, and the ecological consequences of making informed decisions. The first two stages constitute the domains of, e.g. sensory ecology and behavioral ecology. The exploration of the consequences of information use at larger spatial and temporal scales in ecology has lagged behind these other disciplines. In our overview we characterize information, discuss statistical decision theory as a quantitative framework to analyze information and decision‐making, and discuss potential ecological ramifications. Rather than attempt a cursory review of the enormity of the scope of information we highlight information use in development, breeding habitat selection, and interceptive eavesdropping on alarm calls. Through these topics we discuss specific examples of ecological information use and the emerging ecological consequences. We emphasize recurring themes: information is collected from multiple sources, over varying temporal and spatial scales, and in many cases links heterospecifics to one another. We conclude by breaking from specific ecological contexts to explore implications of information as a central organizing principle, including: information webs, information as a component of the niche concept, and information as an ecosystem process. With information having such an enormous reach in ecology we further cast a spotlight on the potential harmful effects of anthropogenic noise and info‐disruption. 相似文献