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EcoHealth - Interspecies transmission may play a key role in the evolution and ecology of influenza A viruses. The importance of marine mammals as hosts or carriers of potential zoonotic pathogens... 相似文献
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Hamid Reza Naghibi Beidokhti Reza Ghaffarzadegan Sasan Mirzakhanlouei Leila Ghazizadeh Farid Abedin Dorkoosh 《AAPS PharmSciTech》2017,18(1):115-129
The objective of this study was to investigate the combined influence of independent variables in the preparation of folic acid-chitosan-methotrexate nanoparticles (FA-Chi-MTX NPs). These NPs were designed and prepared for targeted drug delivery in tumor. The NPs of each batch were prepared by coaxial electrospray atomization method and evaluated for particle size (PS) and particle size distribution (PSD). The independent variables were selected to be concentration of FA-chitosan, ratio of shell solution flow rate to core solution flow rate, and applied voltage. The process design of experiments (DOE) was obtained with three factors in three levels by Design expert software. Box-Behnken design was used to select 15 batches of experiments randomly. The chemical structure of FA-chitosan was examined by FTIR. The NPs of each batch were collected separately, and morphologies of NPs were investigated by field emission scanning electron microscope (FE-SEM). The captured pictures of all batches were analyzed by ImageJ software. Mean PS and PSD were calculated for each batch. Polynomial equation was produced for each response. The FE-SEM results showed the mean diameter of the core-shell NPs was around 304 nm, and nearly 30% of the produced NPs are in the desirable range. Optimum formulations were selected. The validation of DOE optimization results showed errors around 2.5 and 2.3% for PS and PSD, respectively. Moreover, the feasibility of using prepared NPs to target tumor extracellular pH was shown, as drug release was greater in the pH of endosome (acidic medium). Finally, our results proved that FA-Chi-MTX NPs were active against the human epithelial cervical cancer (HeLa) cells. 相似文献
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Naoya Takayama Alex Murison Shin-ichiro Takayanagi Christopher Arlidge Stanley Zhou Laura Garcia-Prat Michelle Chan-Seng-Yue Sasan Zandi Olga I. Gan Héléna Boutzen Kerstin B. Kaufmann Aaron Trotman-Grant Erwin Schoof Ken Kron Noelia Díaz John J.Y. Lee Tiago Medina Daniel D. De Carvalho Mathieu Lupien 《Cell Stem Cell》2021,28(3):488-501.e10