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Russian Journal of Genetics - Parkinson’s disease (PD) as a genetically heterogeneous disease is the second common neurological disorder which is associated with motor deficits and dementia... 相似文献
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Masoodifar Mahsa Hajihashemi Saeed Pazhoohan Saeed Nazemi Samad Mojadadi Mohammad-Shafi 《Purinergic signalling》2021,17(1):143-150
Purinergic Signalling - Recent studies have shown that mesenchymal stem cells (MSCs) and their conditioned medium (CM) have potential therapeutic effects in animal models of neuropathic pain (NP).... 相似文献
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Darvishi Vahid Darvishi Saeed Bahrami-Bavani Marziyeh Navidbakhsh Mahdi Asiaei Sasan 《Biomechanics and modeling in mechanobiology》2021,20(5):1809-1817
Biomechanics and Modeling in Mechanobiology - Coronavirus and its spread all over the world have been the most challenging crisis in 2020. Hospitals are categorized among the most vulnerable... 相似文献
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Meamar AR Guyot K Certad G Dei-Cas E Mohraz M Mohebali M Mohammad K Mehbod AA Rezaie S Rezaian M 《Applied and environmental microbiology》2007,73(3):1033-1035
Isolates of Cryptosporidium spp. from human and animal hosts in Iran were characterized on the basis of both the 18S rRNA gene and the Laxer locus. Three Cryptosporidium species, C. hominis, C. parvum, and C. meleagridis, were recognized, and zoonotically transmitted C. parvum was the predominant species found in humans. 相似文献
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Moghadam Sogand Sasan Ghahramani Maryam Khoshaman Kazem Oryan Ahmad Moosavi-Movahedi Ali Akbar Kurganov Boris I. Yousefi Reza 《Biochemistry. Biokhimii?a》2022,87(2):91-105
Biochemistry (Moscow) - The study was aimed to evaluate the impact of peroxynitrite (PON, oxidative stress agent in diabetes), methylglyoxal (MGO, diabetes-associated reactive carbonyl compound),... 相似文献
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Saadat M Bahaoddini A Nazemi S 《Biochemical and biophysical research communications》2004,313(3):568-569
In order to show the alteration of blood pressure in subjects chronically exposed to natural gas containing sulfur compounds, the present study was done. The blood pressure of 94 (43 males, 51 females) of healthy individuals living in the polluted area of Masjid-i-Sulaiman (Khozestan province, southwest of Iran) was measured. The non-parametric Sign test was applied in order to detect differences between the study subjects and the normal mean values according to the sex and age of subjects. Statistical analysis showed that the systolic blood pressure significantly decreased (Z=-2.74; P=0.0031) while the diastolic blood pressure (Z=+2.11; P=0.0174) and heart rate (Z=+3.62; P<0.001) significantly increased in individuals living in the contaminated areas compared with those of normal mean values. The systolic and diastolic blood pressure decreased and increased, respectively, in individuals chronically exposed to natural sour gas containing sulfur compounds. 相似文献
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Plant profilins form a well-known panallergen family responsible for cross-sensitization between plant foods and pollens. We sought to map T and B-cell epitopes on the Iranian Crocus sativus profilin by bioinformatics tools. The predicted peptides are useful for further vaccine development. 相似文献
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Amir Majlesi Reza Kamali Kakhki Amir Sasan Mozaffari Nejad Rasoul Yousefi Mashouf Amir Roointan Malek Abazari Mohammad Yousef Alikhani 《Saudi Journal of Biological Sciences》2018,25(3):426-430
Plasmid mediated quinolone resistance (PMQR) determinants have arisen as a significant concern in recent years. The aim of this study was screening of resistant-clinical isolates to fluoroquinolone antibiotics and detection of qnr and aac(6′)-Ib-cr genes.For this purpose we collected 100 fluoroquinolone-resistant Enterobacteriaceae which were from 3 hospitals in Hamadan, west provinces of Iran, between October 2012 and June 2013. The all samples were identified by biochemical tests and confirmed by PCR method. Antimicrobial susceptibility to 14 antimicrobial agents including levofloxacin and ciprofloxacin were determined by disk diffusion methods and ciprofloxacin MIC was obtained by broth microdilution method as Clinical Laboratory Standards Institute (CLSI) recommendations. The isolates were screened for the presence of qnrA, qnrB, qnrS and aac(6′)-Ib-cr genes using PCR assay. Among the screened isolates, 64 strains (64%) of Escherichia coli, 23 strains (23%) of Klebsiella pneumoniae, 13 strains (13%) of Proteus mirabilis were collected as quinolone-resistant isolates. out of 100 isolates, two (2%) were positive for qnrS, seventeen (17%) isolates were positive for qnrB and we did not find qnrA gene in any of the isolates. There were also 32 positive isolates for aac(6′)-Ib-cr determinant. We described the prevalence of qnr and aac(6′)-Ib-cr genes in fluoroquinolone-resistant Enterobacteriaceae in Hamadan city. The carriage rate of multidrug-resistant Enterobacteriaceae in healthy people in Hamadan City is extremely high. Moreover, genes encoding transferable quinolones, in particular aac(6′)-Ib-cr, are highly prevalent in these strains. 相似文献
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Zahra Yazdani Alireza Rafiei Monireh Golpour Parisa Zafari Mohammadreza Moonesi Sasan Ghaffari 《Journal of cellular biochemistry》2020,121(3):2064-2076
Interleukin 35 (IL-35), a cytokine mainly produced by regulatory T cells (Treg cells), is composed of an Epstein-Barr virus–induced gene 3 β-chain and an IL-12 p35 α-chain. IL-35 causes tumorigenicity in cancer, protects cancer cells against apoptosis, and facilitates cancer progression. However, a few reports have referred to its contradictory roles in cancer prevention. Therefore, the exact purpose of this cytokine in cancer development has become a fundamental question that needs to be answered. In this review, we explain the structure of IL-35 and its receptors and their different signaling pathways. Finally, the function of IL-35 in some cancers and the possible application of this cytokine in approaches for cancer therapy have been discussed. 相似文献