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81.
The objective of this work was to study mercury chloride effects on the function and integrity of sea bass (Dicentrarchus labrax) head kidney macrophages (S-HKM), and to evaluate the response of HgCl2-exposed cells to macrophage activating factor(s) (MAF) produced by sea bass head kidney leukocytes. There was considerable variability in the effects of HgCl2 on the production of reactive oxygen species (ROS) by S-HKM. When incubated with HgCl2, cells from five out of nine fish tested showed a decrease in ROS production as compared to cells incubated with medium alone. In those cultures, MAF addition prevented the mercury chloride-induced decrease in ROS production. In other S-HKM cultures isolated from different fish, mercury chloride abrogated the up-regulating effect of MAF on the respiratory burst. MAF activation of the phagocytic activity of S-HKM was also impaired by HgCl2 addition. Mercury chloride induced apoptosis in S-HKM cultures and MAF addition prevented this effect. 相似文献
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Jonathan M. Chase Brian J. McGill Patrick L. Thompson Laura H. Anto Amanda E. Bates Shane A. Blowes Maria Dornelas Andrew Gonzalez Anne E. Magurran Sarah R. Supp Marten Winter Anne D. Bjorkman Helge Bruelheide Jarrett E. K. Byrnes Juliano Sarmento Cabral Robin Elahi Catalina Gomez Hector M. Guzman Forest Isbell Isla H. Myers‐Smith Holly P. Jones Jes Hines Mark Vellend Conor Waldock Mary O'Connor 《Oikos》2019,128(8):1079-1091
Humans have elevated global extinction rates and thus lowered global scale species richness. However, there is no a priori reason to expect that losses of global species richness should always, or even often, trickle down to losses of species richness at regional and local scales, even though this relationship is often assumed. Here, we show that scale can modulate our estimates of species richness change through time in the face of anthropogenic pressures, but not in a unidirectional way. Instead, the magnitude of species richness change through time can increase, decrease, reverse, or be unimodal across spatial scales. Using several case studies, we show different forms of scale‐dependent richness change through time in the face of anthropogenic pressures. For example, Central American corals show a homogenization pattern, where small scale richness is largely unchanged through time, while larger scale richness change is highly negative. Alternatively, birds in North America showed a differentiation effect, where species richness was again largely unchanged through time at small scales, but was more positive at larger scales. Finally, we collated data from a heterogeneous set of studies of different taxa measured through time from sites ranging from small plots to entire continents, and found highly variable patterns that nevertheless imply complex scale‐dependence in several taxa. In summary, understanding how biodiversity is changing in the Anthropocene requires an explicit recognition of the influence of spatial scale, and we conclude with some recommendations for how to better incorporate scale into our estimates of change. 相似文献
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V.?C.?Sarmento T.?P.?Souza A.?M.?Esteves P.?J.?P.?SantosEmail author 《Coral reefs (Online)》2015,34(3):955-966
Despite the increasing risk that ocean acidification will modify benthic communities, great uncertainty remains about how this impact will affect the lower trophic levels, such as members of the meiofauna. A mesocosm experiment was conducted to investigate the effects of water acidification on a phytal meiofauna community from a coral reef. Community samples collected from the coral reef subtidal zone (Recife de Fora Municipal Marine Park, Porto Seguro, Bahia, Brazil), using artificial substrate units, were exposed to a control pH (ambient seawater) and to three levels of seawater acidification (pH reductions of 0.3, 0.6, and 0.9 units below ambient) and collected after 15 and 30 d. After 30 d of exposure, major changes in the structure of the meiofauna community were observed in response to reduced pH. The major meiofauna groups showed divergent responses to acidification. Harpacticoida and Polychaeta densities did not show significant differences due to pH. Nematoda, Ostracoda, Turbellaria, and Tardigrada exhibited their highest densities in low-pH treatments (especially at the pH reduction of 0.6 units, pH 7.5), while harpacticoid nauplii were strongly negatively affected by low pH. This community-based mesocosm study supports previous suggestions that ocean acidification induces important changes in the structure of marine benthic communities. Considering the importance of meiofauna in the food web of coral reef ecosystems, the results presented here demonstrate that the trophic functioning of coral reefs is seriously threatened by ocean acidification. 相似文献
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The pharmacological activity of insulin-loaded dextran sulfate/chitosan nanoparticles was evaluated following oral dosage in diabetic rats. Nanoparticles were mucoadhesive and negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract. Insulin association efficiency was over 70% and was released in a pH-dependent manner under simulated gastrointestinal conditions. Orally delivered nanoparticles lowered basal serum glucose levels in diabetic rats around 35% with 50 and 100 IU/kg doses sustaining hypoglycemia over 24 h. Pharmacological availability was 5.6 and 3.4% for the 50 and 100 IU/kg doses, respectively, a significant increase over 1.6%, determined for oral insulin alone in solution. Confocal microscopic examinations of FITC-labeled insulin nanoparticles showed adhesion to rat intestinal epithelium, and internalization of insulin within the intestinal mucosa. Encapsulation of insulin into dextran sulfate/chitosan nanoparticles was a key factor in the improvement of the bioavailability of its oral delivery over insulin solution. 相似文献
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Human trampling is a common type of disturbance associated with outdoor recreational activities in coastal ecosystems. In
this study, the effect of trampling on the meiofaunal harpacticoid copepod assemblage inhabiting turfs on a coral reef was
investigated. In Porto de Galinhas, northeastern Brazil, reef formations near the beach are one of the main touristic destinations
in the country. To assess trampling impact, two areas were compared: a protected area and an area subject to intensive tourism.
Densities of total Harpacticoida and of the most abundant harpacticoid species showed strong reductions in the trampled area.
An analysis of covariance revealed that the loss of phytal habitat was not the main source of density reductions, showing
that trampling affected the animals directly. In addition, multivariate analysis demonstrated differences in the structure
of harpacticoid assemblages between areas. Of the 43 species identified, 12 were detected by the Indicator Species Analyses
as being indicators of the protected or trampled areas. Moreover, species richness was reduced in the area open to tourism.
At least 25 harpacticoids are new species for science, of these, 20 were more abundant or occurred only in the protected area,
while five were more abundant or occurred only in the trampled area; thus, our results highlight the possibility of local
extinction of still-unknown species as one of the potential consequences of trampling on coral reefs. 相似文献