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51.
Nigar Sehrish Nazneen Shahla Khan Sardar Ali Neelum Sarwar Tasneem 《Journal of Plant Growth Regulation》2023,42(1):121-133
Journal of Plant Growth Regulation - The response of Vigna radiata L. (mung bean) to tropospheric ozone (O3) phytotoxicity using Ethylenediurea (EDU) and magnesium nitrate (Mg(NO3)2,... 相似文献
52.
A mathematical model of one of the mechanisms of membrane fusion is described. From the model, it follows that when the outer leaflet of a membrane formed of bilayer stabilizing phospholipids is enlarged over the inner leaflet, convexities are formed on the membrane surface. This asymmetric enlargement of the outer layer over the inner layer occurs when fusogenic peptides, such as cobra venom cytotoxin and bee venom melittin, interact with the outer membrane monolayer. This phenomenon facilitates not only membrane fusion, but it might also play an important role in physiological processes, such as inter- and intracellular communications and cellular motility. 相似文献
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Sphingosine 1-phosphate and lysophosphatidic acid are two phospholipid growth factors whose importance in physiology and pathophysiology is becoming more and more apparent. Structure-activity relationships for agonism and antagonism at the thirteen known cell-surface and one intracellular receptor are described. Particular emphasis is placed on ligands having different selectivity than the parent molecules. Structural insights regarding agonist and antagonist recognition by the receptors from both computational modeling studies and crystallography are also discussed. 相似文献
55.
56.
Abid Ali Sardar Khan Ijaz Ali Shahid Karim Itabajara da Silva Vaz Jr. Carlos Termignoni 《Physiological Entomology》2015,40(3):177-188
Tick saliva assists feeding through a complex mixture of compounds that disarm the host homeostasis processes, such as platelet aggregation, vasoconstriction and blood clotting, as well as innate and acquired immune responses. Although the various properties of tick salivary glands have sparked great interest as candidate sources for anti‐tick vaccines to prevent tick and tick‐borne diseases, antigens that can be useful to induce an immune response against tick bites or the pathogens transmitted by ticks have not yet been developed. Metalloproteases, which have been found in tick saliva, salivary gland, ovary and midgut, play an important role in inflammation, immunomodulation, fibrinolysis, blood protein digestion, nociception, vitellogenesis, remodelling of extracellular matrix and pathogen transmission. A large proportion of tick metalloproteases belong to the metzincin group, whose members characteristically have a highly conserved zinc‐binding motif integrated into the central α helix at the active site, and a methionine‐containing triad called Met‐turn followed by a cysteine‐rich domain at the C‐terminal site. This review discusses specifically the biological aspects of metalloproteases in tick physiology that have been published to date. 相似文献
57.
Vishnu Priya Veeraraghavan Nanthini Devi Periadurai Thiruventhan Karunakaran Sardar Hussain Krishna Mohan Surapaneni Xinsheng Jiao 《Saudi Journal of Biological Sciences》2021,28(7):3633-3640
Scutellaria barbata is a perennial herb which was vastly prescribed in Chinese medicine to treat inflammations, infections and it is also used a detoxifying agent. We synthesized silver nanoparticles with Scutellaria barbata extract and characterized the nanoparticles with UV–Vis spectroscopic analysis, TEM, AFM, FTIR and XRD. The biofilm inhibiting property of synthesized silver nanoparticles were examined with XTT reduction assay and the antimicrobial property was examined with well diffusion method. The silver nanoparticles were also coated with cotton fabrics and their efficacy against antimicrobials was analyzed to prove its application. The cytotoxic property of synthesized silver nanoparticles was examined with L929 fibroblast cells using MTT assay. Finally we analyzed the wound healing property of synthesized silver nanoparticles with wound scratch assay. The result of our UV–Vis spectroscopic analysis confirms Scutellaria barbata aqueous extract reduced silver ions and synthesized silver nanoparticles. The characterization studies TEM, AFM, FTIR and XRD confirms the synthesized silver nanoparticles are in ideal shape and size to be utilized as a drug. The XTT reduction assay proves silver nanoparticles effectively inhibits the biofilm formation in both resistant and sensitive strains. Antimicrobial sensitivity tests confirms synthesized silver nanoparticles and cotton coated synthesized silver nanoparticles both are effective against gram positive, gram negative and fungal species. Further the results of MTT assay confirms the synthesized silver nanoparticles are non toxic and finally the wound healing potency of the nanoparticles was confirmed with wound scratch assay. Over all our results authentically confirms the silver nanoparticles synthesized with Scutellaria barbata aqueous extract is potent wound healing drug. 相似文献
58.
Naushad Ali Izhar Hussain Sardar Ali Naqib Ullah Khan Ijaz Hussain 《Saudi Journal of Biological Sciences》2021,28(1):347-352
Genetic diversity play key role in the germplasm improvement which is directly correlated with the crop production. Various statistical techniques have been used to study diversity among different genotypes. Among these techniques multivariate is most frequently used one for the genetic association of genotypes. In the present study a total of 64 advance lines included one check cultivar were evaluated under the field conditions of Cereal Crop Research Institute, Pirsabaq Nowshera, Pakistan during September 2017. Data were recorded for nine different parameters. Multivariate analysis divided the total 64 genotypes into four groups. The first five PCs with Eigen values > 1 contributed 86.95% of the variability amongst genotypes. Characters with maximum values in PC1 were Spikelets spike-1 (SPPS) (0.732), spike length (SPL) (0.722) and biological yield (BY) (0.607), PC2 comprised of 100-grain weight (TGW) (0.605), grain yield (GY) (0.482) while days to heading (DH) (0.393), for PC3 major contributors were BY (0.550) and number of tillers meter square-1 (NTPS) (0.289), the contribution of PC4 were flag leaf area (FLA) (0.716) and SPL (0.298) and the maximum values for various traits in PC5 were SPPS (0.732), SPL (0.722) and BY (0.607). From the findings of present study best performing lines can be directly recommended for general cultivation or to be used in future breeding programs. 相似文献
59.
B. V. S. Suneel Kumar Rohith Kotla Revanth Buddiga Jyoti Roy Sardar Shamshair Singh Rambabu Gundla Muttineni Ravikumar Jagarlapudi A. R. P. Sarma 《Journal of molecular modeling》2011,17(1):151-163
Structure and ligand based pharmacophore modeling and docking studies carried out using diversified set of c-Jun N-terminal
kinase-3 (JNK3) inhibitors are presented in this paper. Ligand based pharmacophore model (LBPM) was developed for 106 inhibitors
of JNK3 using a training set of 21 compounds to reveal structural and chemical features necessary for these molecules to inhibit
JNK3. Hypo1 consisted of two hydrogen bond acceptors (HBA), one hydrogen bond donor (HBD), and a hydrophobic (HY) feature
with a correlation coefficient (r2) of 0.950. This pharmacophore model was validated using test set containing 85 inhibitors and had a good r2 of 0.846. All the molecules were docked using Glide software and interestingly, all the docked conformations showed hydrogen
bond interactions with important hinge region amino acids (Gln155 and Met149) and these interactions were compared with Hypo1
features. The results of ligand based pharmacophore model (LBPM) and docking studies are validated each other. The structure
based pharmacophore model (SBPM) studies have identified additional features, two hydrogen bond donors and one hydrogen bond
acceptor. The combination of these methodologies is useful in designing ideal pharmacophore which provides a powerful tool
for the discovery of novel and selective JNK3 inhibitors. 相似文献
60.
Jinlong Jian Shuai Zhao Qingyun Tian Elena Gonzalez-Gugel Jyoti Joshi Mundra Sardar MZ Uddin Ben Liu Brendon Richbourgh Ryan Brunetti Chuan-ju Liu 《FEBS letters》2013
We previously reported that PGRN directly bound to TNF receptors (TNFR) in vitro and in chondrocytes (Tang, et al., Science, 2011). Here we report that PGRN also associated with TNFR in splenocytes, and inhibited the binding of TNFα to immune cells. Proper folding of PGRN is essential for its binding to TNFR, as DTT treatment abolished its binding to TNFR. In contrast, the binding of PGRN to Sortilin was enhanced by DTT. Protein interaction assays with mutants of the TNFR extracellular domain demonstrated that CRD2 and CRD3 of TNFR are important for the interaction with PGRN, similar to the binding to TNFα. Taken together, these findings provide the molecular basis underlying PGRN/TNFR interaction and PGRN-mediated anti-inflammatory activity in various autoimmune diseases and conditions. 相似文献