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21.
Yakhine-Diop Sokhna M. S. Rodríguez-Arribas Mario Canales-Cortés Saray Martínez-Chacón Guadalupe Uribe-Carretero Elisabet Blanco-Benítez Mercedes Duque-González Gema Paredes-Barquero Marta Alegre-Cortés Eva Climent Vicente Aiastui Ana López de Munain Adolfo Bravo-San Pedro José M. Niso-Santano Mireia Fuentes José M. González-Polo Rosa A. 《Cell biology and toxicology》2022,38(5):889-911
Cell Biology and Toxicology - Autophagy is a mechanism responsible for the degradation of cellular components to maintain their homeostasis. However, autophagy is commonly altered and compromised... 相似文献
22.
Elizabeth A. Hobson Matthew J. Silk Nina H. Fefferman Daniel B. Larremore Puck Rombach Saray Shai Noa Pinter-Wollman 《Biological reviews of the Cambridge Philosophical Society》2021,96(6):2716-2734
Analysing social networks is challenging. Key features of relational data require the use of non-standard statistical methods such as developing system-specific null, or reference, models that randomize one or more components of the observed data. Here we review a variety of randomization procedures that generate reference models for social network analysis. Reference models provide an expectation for hypothesis testing when analysing network data. We outline the key stages in producing an effective reference model and detail four approaches for generating reference distributions: permutation, resampling, sampling from a distribution, and generative models. We highlight when each type of approach would be appropriate and note potential pitfalls for researchers to avoid. Throughout, we illustrate our points with examples from a simulated social system. Our aim is to provide social network researchers with a deeper understanding of analytical approaches to enhance their confidence when tailoring reference models to specific research questions. 相似文献
23.
Elie Beit‐Yannai Saray Tabak W. Daniel Stamer 《Journal of cellular and molecular medicine》2018,22(3):2001-2006
Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome–exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome‐mediated signalling. We discuss experiments to test this hypothesis and potential relevance in health and disease. 相似文献