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21.
C. Sudhakar Reddy S. Vazeed Pasha K. V. Satish K. R. L. Saranya C. S. Jha Y. V. N. Krishna Murthy 《Biodiversity and Conservation》2018,27(1):91-107
This study quantifies the nationwide land cover and long-term changes in forests and its implications on forest fragmentation in Nepal. The multi-source datasets were used to generate the forest cover information for 1930, 1975, 1985, 1995, 2005 and 2014. This study analyzes distribution of land cover, rate of deforestation, changes across forest types, forest canopy density and pattern of fragmentation. The land cover legend for 2014 is consisting of 21 classes: tropical dry deciduous sal forest, tropical moist deciduous sal forest, subtropical broad-leaved forest, subtropical pine forest, lower temperate broad leaved forest, upper temperate broad leaved forest, lower temperate mixed broad leaved forest, upper temperate mixed broad leaved forest, temperate needle leaved forest, subalpine forest, plantations, tropical scrub, subtropical scrub, temperate scrub, alpine scrub, grassland, agriculture, water bodies, barren land and settlements. The forest cover statistics for Nepal obtained in this study shows an area of 76,710 km2 in 1930 which has decreased to 39,392 km2 in 2014. A net loss of 37,318 km2 (48.6%) was observed in last eight decades. Analysis of annual rate of net deforestation for the recent period indicates 0.01% during 2005–2014. An increase in the number of forest patches from 6925 (in 1930) to 42,961 (in 2014) was noticed. The significant observation is 75.5% of reduction in core 3 forest, whereas, patch, perforated and edge classes show the increase in percentage of fragmentation classes from 1930 to 2014. The results of this work will support the understanding of deforestation and its consequences on fragmentation for maintaining and improving the forest resources of Nepal. 相似文献
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Frequent genes in rare diseases: panel‐based next generation sequencing to disclose causal mutations in hereditary neuropathies 下载免费PDF全文
Maike F. Dohrn Nicola Glöckle Lejla Mulahasanovic Corina Heller Julia Mohr Christine Bauer Erik Riesch Andrea Becker Florian Battke Konstanze Hörtnagel Thorsten Hornemann Saranya Suriyanarayanan Markus Blankenburg Jörg B. Schulz Kristl G. Claeys Burkhard Gess Istvan Katona Andreas Ferbert Debora Vittore Alexander Grimm Stefan Wolking Ludger Schöls Holger Lerche G. Christoph Korenke Dirk Fischer Bertold Schrank Urania Kotzaeridou Gerhard Kurlemann Bianca Dräger Anja Schirmacher Peter Young Beate Schlotter‐Weigel Saskia Biskup 《Journal of neurochemistry》2017,143(5):507-522
24.
Arumugam Geetha Panneerselvam Saranya Sam Annie Jeyachristy Rajagopal Surendran Arunachalam Sundaram 《Biological trace element research》2009,130(3):229-240
Altered copper homeostasis and oxidative stress have been observed in patients with hepatocellular carcinoma. Non-ceruloplasmin
copper, the free form, is a potent pro-oxidant than the protein bound copper. The aim of the present study was to evaluate
which form of copper can be correlated with the oxidative stress in the circulation and in the malignant liver tissues of
hepatocellular carcinoma patients. Hepatocellular carcinoma patients (grades II and III, n = 18) were enrolled in this study. Serum levels of total, free and bound copper, ceruloplasmin, iron, iron-binding capacity,
lipid peroxidation products, and enzymatic and non-enzymatic antioxidants were quantified in serum and in malignant liver
tissues and compared with those of normal samples (n = 20). A significant positive correlation between the serum non-ceruloplasmin copper and lipid peroxidation products and
negative correlation with antioxidants were observed in hepatocellular carcinoma patients. In liver tissue, glutathione peroxidase,
superoxide dismutase, and catalase activity were significantly decreased with concomitant elevation in oxidative stress markers.
Our experiment revealed that the elevation in non-ceruloplasmin copper has high relevance with the oxidative stress than the
bound copper. 相似文献
25.
Modeling of the potential coiled-coil structure of snapin protein and its interaction with SNARE complex 总被引:1,自引:0,他引:1 下载免费PDF全文
Autism is a developmental disability causing learning and memory disorder. The heart of the search for a cure for this syndrome is the need to understand dendrite branch patterning, a process crucial for proper synaptic transmission. Due to the association of snapin with the SNARE complex and its role in synaptic transmission it is reported as a potential drug target for autism therapies. We wish to impart the noesis of the 3D structure of the snapin protein, and in this chase we predict the native structure from its sequence of amino acid residues using the classical Comparative protein structure modeling methods. The predicted protein model can be of great assistance in understanding the structural insights, which is necessary to understand the protein function. Understanding the interactions between snapin and SNARE complex is crucial in studying its role in the neurotransmitter release process. We also presented a computational model that shows the interaction between the snapin and SNAP-25 protein, a part of the larger SNARE complex. 相似文献
26.
Chitosan and its derivatives for gene delivery 总被引:2,自引:0,他引:2
Saranya N Moorthi A Saravanan S Devi MP Selvamurugan N 《International journal of biological macromolecules》2011,48(2):234-238
Gene delivery can particularly be used for the treatment of diseases by the insertion of genetic materials (DNA and RNA) into mammalian cells either to express new proteins or to prevent the expression of existing proteins. Chitosan, a natural polymer is nontoxic, biocompatible, and biodegradable and it is used as a support material for gene delivery. However, practical use of chitosan has been mainly limited to its unmodified forms, and thus modified chitosans can be used for the wide range of biomedical applications including the interaction and intracellular delivery of genetic materials. In this context, this review paper provides the recent development on chitosan derivatives available for gene delivery. 相似文献
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Appunu C Ganesan G Kalita M Kaushik R Saranya B Prabavathy VR Sudha N 《Current microbiology》2011,62(4):1230-1238
Horsegram [Macrotyloma uniflorum (Lam.) Verdc.) is an important grain legume and fodder crop in India. Information on root nodule endosymbionts of this legume
in India is limited. In the present study, 69 isolates from naturally occurring root nodules of horsegram collected from two
agro-eco-climatic regions of South India was analyzed by generation rate, acid/alkali reaction on YMA medium, restriction
fragment length polymorphism analysis of 16S-23S rDNA intergenic spacer region (IGS), and sequence analyses of IGS and housekeeping
genes glnII and recA. Based on the rDNA IGS RFLP by means of three restriction enzymes rhizobia were grouped in five clusters (I–V). By sequence
analysis of 16S-23S rDNA IGS identified genotypes of horsegram rhizobia were distributed into five divergent lineages of Bradyrhizobium genus which comprised (I) the IGS type IV rhizobia and valid species B. yuanmingense, (II) the strains of IGS type I and Bradyrhizobium sp. ORS 3257 isolated from Vigna sp., (III) the strains of the IGS type II and Bradyrhizobium sp. CIRADAc12 from Acacia sp., (IV) the IGS type V strains and Bradyrhizobium sp. genospecies IV, and (V) comprising genetically distinct IGS type III strains which probably represent an uncharacterized
new genomic species. Nearly, 87% of indigenous horsegram isolates (IGS types I, II, III, and V) could not be related to any
other species within the genus Bradyrhizobium. Phylogeny based on housekeeping glnII and recA genes confirmed those results found by the analysis of the IGS sequence. All the isolated rhizobia nodulated Macrotyloma sp. and Vigna spp., and only some of them formed nodules on Arachis hypogeae. The isolates within each IGS type varied in their ability to fix nitrogen. Selection for high symbiotic effective strains
could reward horsegram production in poor soils of South India where this legume is largely cultivated. 相似文献
28.
Kalai Selvi Palaniswamy Vijaya Padma Vishwanadha Saranya Ramalingam Singaravelu 《Cell stress & chaperones》2014,19(3):409-419
Humans are systemically exposed to persistent organic pollutants, of which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has become a major environmental concern. Exposure to TCDD results in a wide variety of adverse health effects which is mediated by oxidative stress through CYP1A1 activation and arachidonic acid metabolites. Eicosapentaenoic acid (EPA) exhibits antioxidant property and competes with arachidonic acid in membrane phospholipids and produces anti-inflammatory EPA derivatives. Since both EPA and its derivatives have been reported to enhance the antioxidant mechanism, the present study aimed at studying whether EPA could offer protection against TCDD-induced oxidative stress and nephrotoxicity in Wistar rats. Estimation of kidney markers (serum urea and creatinine) and histopathological studies revealed that EPA treatment significantly reduced TCDD-induced renal damage. TCDD-induced oxidative damage was reflected in a significant increase in CYP1A1 activity and lipid peroxide levels with a concomitant decline in non-enzymic antioxidant (GSH) and various enzymic antioxidants such catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), and glutathione peroxidase (GPx). In addition, TCDD-induced oxidative stress also resulted in decline in Na+-K+ and Mg2+ATPases activities with increase in Ca2+ ATPases activity. Oral treatment with EPA showed a significant cytoprotection against TCDD-induced renal oxidative stress by decreased CYP1A1 activity and enhanced antioxidant status. TCDD-induced alterations in ATPase enzyme activities were also prevented by EPA treatment. Our results show clear evidence that EPA ameliorates TCDD-induced oxidative stress and kidney damage; thus suggest the potential of EPA as an effective therapeutic agent against toxic effects mediated through redox imbalance. 相似文献
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Two-hybrid technologies in proteomics research 总被引:5,自引:0,他引:5
Given that protein-protein interactions (PPIs) regulate nearly every living process; the exploration of global and pathway-specific protein interaction networks is expected to have major implications in the understanding of diseases and for drug discovery. Consequently, the development and application of methodologies that address physical associations among proteins is of major importance in today's proteomics research. The most widely and successfully used methodology to assess PPIs is the yeast two-hybrid system (YTH). Here we present an overview on the current applications of YTH and variant technologies in yeast and mammalian systems. Two-hybrid-based methods will not only continue to have a dominant role in the assessment of protein interactomes but will also become important in the development of novel compounds that target protein interaction interfaces for therapeutic intervention. 相似文献
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Panigrahi A. Esakkiraj P. Saranya C. Das R. R. Sundaram M. Sudheer N. S. Biju I. F. Jayanthi M. 《Probiotics and antimicrobial proteins》2022,14(2):277-287
Probiotics and Antimicrobial Proteins - Experiments were conducted to evaluate the probiotic effect of bio-augmented Bacillus tequilensis AP BFT3 on improving production, immune response, and... 相似文献