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排序方式: 共有192条查询结果,搜索用时 312 毫秒
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93.
Bernard Peissel Daniela Zaffaroni Simonetta Pazzaglia Giacomo Manenti Nicola Zanesi Ignazio Zedda Simonetta Rebessi Vincenzo Covelli Tommaso A. Dragani Anna Saran 《Mammalian genome》2001,12(4):291-294
Car-R and Car-S outbred mouse lines, phenotypically selected for resistance and susceptibility to skin carcinogenesis respectively,
show significant linkage disequilibrium (LD) at genetic markers mapping on chromosomal regions where skin cancer modifier
loci (Skts3, Skts1, and Psl1 on Chrs 5, 7, and 9 respectively) have been mapped in standard crosses. Analysis of these regions for genetic linkage with
skin cancer phenotypes in 245 (Car-R × Car-S)F2 intercross mice, by using single nucleotide polymorphisms (SNPs), revealed significant linkage at a possible allelic form
of the Skts1 locus, whose mapping region was shortened to a <5.5-cM interval near the Tyr locus. The Car-derived Skts1 locus was linked with papilloma multiplicity and latency by a recessive inheritance of the susceptibility allele. Putative
loci on Chr 5 (Skts3) and 9 (Psl1) showed no significant linkage. These results point to the important role of the Stks1 locus in mouse skin tumorigenesis in independent crosses. The shortened Skts1 mapping region should facilitate the identification of candidate genes.
Received: 23 June 2000 / Accepted: 22 November 2000 相似文献
94.
Saran M 《Free radical research》2003,37(10):1045-1059
Production of superoxide anion O2••- by the membrane-bound enzyme NADPH oxidase of phagocytes is a long-known phenomenon; it is generally assumed that O2• kill bacterial intruders. The details and the chemistry of the killing process have, however, remained a mystery. Isoforms of NADPH oxidase exist in membranes of nearly every cell, suggesting that reactive oxygen species (ROS) participate in intra- and intercellular signaling processes. What the nature of the signal is exactly, how it is transmitted, and what structural characteristics a receptor of a "radical message" must have, have not been addressed convincingly. This review discusses how the action of messengers is in agreement with radical-specific behavior.
In search for the smallest common denominator of cellular free radical activity we hypothesize that O2•e acid, HO2&bull under primordial conditions as regulators of membrane mechanics and that isoprostanes, widely used markers of "oxidative stress", may be an adventitious correlate of this biologic activity of O2•location="post" arrange="compact">2&bullre is presented that suggests that O2•location="post" arrange="compact">2&bullfying cell membranes, help other agents gain access to the hydrophobic region of phospholipid bilayers and hence contribute to lipid-dependent signaling cascades. With this, O2•location="post" arrange="compact">2&bullndispensable adjuvants for the generation of cellular signals, for membrane transport, channel gating and hence, in a global sense, for cell viability and growth. We also suggest that many of the allegedly O2•ial pathologies and carcinogenic derailments are due to membrane-modifying activity rather than other chemical reactions of O2•location="post" arrange="compact">2&bull this picture is the potential evolution of the "radical theory of ageing" to a "lipid theory of aging". 相似文献
In search for the smallest common denominator of cellular free radical activity we hypothesize that O2•e acid, HO2&bull under primordial conditions as regulators of membrane mechanics and that isoprostanes, widely used markers of "oxidative stress", may be an adventitious correlate of this biologic activity of O2•location="post" arrange="compact">2&bullre is presented that suggests that O2•location="post" arrange="compact">2&bullfying cell membranes, help other agents gain access to the hydrophobic region of phospholipid bilayers and hence contribute to lipid-dependent signaling cascades. With this, O2•location="post" arrange="compact">2&bullndispensable adjuvants for the generation of cellular signals, for membrane transport, channel gating and hence, in a global sense, for cell viability and growth. We also suggest that many of the allegedly O2•ial pathologies and carcinogenic derailments are due to membrane-modifying activity rather than other chemical reactions of O2•location="post" arrange="compact">2&bull this picture is the potential evolution of the "radical theory of ageing" to a "lipid theory of aging". 相似文献
95.
Desai P Prachand M Coutinho E Saran A Bodi J Süli-Vargha H 《International journal of biological macromolecules》2002,30(3-4):187-195
Alpha-melanotropin (alpha-MSH, i.e. alpha-melanocyte stimulating hormone), tridecapeptide (Ac-Ser(1)-Tyr-Ser-Met-G1u(5)-His-Phe-Arg-Trp-Gly(10)-Lys-Pro-Val(13)-NH(2)), has been extensively studied to understand structure-activity relationships. The core sequence (His-Phe-Arg-Trp) is conserved in several species and is considered as the primary active site or "message sequence". Attempts have been made to design conformationally constrained cyclic analogs containing the message sequence to improve the activity. We had earlier reported that the cyclic analog--cyclo[Gly-His-D-Phe-Arg-Trp-Gly], a 18 membered ring system with two fused beta-turn structure, was less active than the corresponding linear peptide. It was suggested that ring size could be an important parameter in the activity of cyclic melanotropic analogs. To investigate the effect of ring size on biological activity, a cyclic heptapeptide, cyclo[Nle(1)-Gly-His-D-Phe-Arg(5)-Trp-Gly(7)], with 21 member ring system was synthesized. This peptide has three orders of magnitude higher biological activity than the cyclic hexapeptide. The conformational study of this cyclic heptapeptide in DMSO-d(6) by NMR and molecular dynamics simulations reveals a structure with two fused beta-turns running across the residues D-Phe(4)-Gly(7) (Type I) and Gly(7)-His(3) (Type II). These findings confirm that stabilization of beta-turns and a relatively larger ring size are essential determinants of activity for cyclic alpha-MSH analogs. 相似文献
96.
Pongpiachan Siwatt Tipmanee Danai Choochuay Chomsri Hattayanone Mattanawadee Deelaman Woranuch Iadtem Natthapong Bunsomboonsakul Suratta Palakun Jittree Poshyachinda Saran Leckngam Apichart Somboonpon Pitipong Panyaphirawat Thirasak Aukkaravittayapun Suparerk Wang Qiyuan Xing Li Li Guohui Han Yongming Cao Junji 《Limnology》2019,20(2):203-214
Limnology - In this study, a historical record of atmospheric deposition in the sediment cores from Songkhla Lake, the second largest lake in Southeast Asia, located in the southern part of... 相似文献
97.
Alvarez-Curto E Saran S Meima M Zobel J Scott C Schaap P 《Development (Cambridge, England)》2007,134(5):959-966
Encystation and sporulation are crucial developmental transitions for solitary and social amoebae, respectively. Whereas little is known of encystation, sporulation requires both extra- and intracellular cAMP. After aggregation of social amoebae, extracellular cAMP binding to surface receptors and intracellular cAMP binding to cAMP-dependent protein kinase (PKA) act together to induce prespore differentiation. Later, a second episode of PKA activation triggers spore maturation. Adenylyl cyclase B (ACB) produces cAMP for maturation, but the cAMP source for prespore induction is unknown. We show that adenylyl cyclase G (ACG) protein is upregulated in prespore tissue after aggregation. acg null mutants show reduced prespore differentiation, which becomes very severe when ACB is also deleted. ACB is normally expressed in prestalk cells, but is upregulated in the prespore region of acg null structures. These data show that ACG induces prespore differentiation in wild-type cells, with ACB capable of partially taking over this function in its absence. 相似文献
98.
Bernard Peissel Daniela Zaffaroni Nicola Zanesi Ignazio Zedda Giacomo Manenti Simonetta Rebessi Simonetta Pazzaglia Gino Doria Vincenzo Covelli Tommaso A. Dragani Anna Saran 《Mammalian genome》2000,11(11):979-981
Car-R (carcinogenesis-resistant) and Car-S (carcinogenesis-susceptible) outbred mice, obtained by phenotypic selection from
an initial intercross of eight inbred strains, show a >100-fold difference in their susceptibility to two-stage skin tumorigenesis.
We found that the lines carry a high degree of genetic polymorphism, with an average heterozygosity of 0.39. This polymorphism
allowed the use of linkage disequilibrium (LD) and haplotype analysis for the mapping of a skin cancer modifier locus on Chr
7, in a short region of 6 cM, around the Tyr gene. Car-S mice inherited the susceptibility allele at this locus from the A/J, BALB/c, SJL/J, and SWR/J strains. Our results
demonstrate the feasibility and usefulness of mapping disease genes by LD in phenotypically selected, genetically heterogeneous
animals.
Received: 16 March 2000 / Accepted: 9 June 2000 相似文献
99.
Fen Wu Karen L. Koenig Anne Zeleniuch-Jacquotte Saran Jonas Yelena Afanasyeva Oktawia P. Wójcik Max Costa Yu Chen 《PloS one》2016,11(2)
Background
Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine’s main biological actions include bile salt conjugation, blood pressure regulation, anti-oxidation, and anti-inflammation.Methods
We conducted a prospective case-control study nested in the New York University Women’s Health Study, a cohort study involving 14,274 women enrolled since 1985. Taurine was measured in pre-diagnostic serum samples of 241 stroke cases and 479 matched controls.Results
There was no statistically significant association between serum taurine and stroke risk in the overall study population. The adjusted ORs for stroke were 1.0 (reference), 0.87 (95% CI, 0.59–1.28), and 1.03 (95% CI, 0.69–1.54) in increasing tertiles of taurine (64.3–126.6, 126.7–152.9, and 153.0–308.5 nmol/mL, respectively). A significant inverse association between serum taurine and stroke risk was observed among never smokers, with an adjusted OR of 0.66 (95% CI, 0.37–1.18) and 0.50 (95% CI, 0.26–0.94) for the second and third tertile, respectively (p for trend = 0.01), but not among past or current smokers (p for interaction < 0.01).Conclusions
We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation.Taurine, Stroke, Epidemiology, Prospective, Case-control study, NYUWHS. 相似文献100.