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Genetic diversity in Indian FCV and burley tobacco cultivars 总被引:1,自引:0,他引:1
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Ganguli Abhijit Rai Pragya Balachandran Sarala Gupta Rakesh Sharma Rashmi Neogi Sutapa Bandyopadhyay 《Biological trace element research》2019,188(2):239-244
Biological Trace Element Research - Indigenous preparations (IPs) have evoked a considerable interest in alleviating infections and chronic diseases and improving wellbeing. While such formulations... 相似文献
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Anne-Laure Page Iza Ciglenecki Ernest Robert Jasmin Laurence Desvignes Francesco Grandesso Jonathan Polonsky Sarala Nicholas Kathryn P. Alberti Klaudia Porten Francisco J. Luquero 《PLoS neglected tropical diseases》2015,9(3)
BackgroundIn 2010 and 2011, Haiti was heavily affected by a large cholera outbreak that spread throughout the country. Although national health structure-based cholera surveillance was rapidly initiated, a substantial number of community cases might have been missed, particularly in remote areas. We conducted a community-based survey in a large rural, mountainous area across four districts of the Nord department including areas with good versus poor accessibility by road, and rapid versus delayed response to the outbreak to document the true cholera burden and assess geographic distribution and risk factors for cholera mortality.Conclusions/SignificanceThese results highlight important geographical disparities and demonstrate that the epidemic caused the highest burden both in terms of cases and deaths in the most remote areas, where up to 5% of the population may have died during the first months of the epidemic. Adapted strategies are needed to rapidly provide treatment as well as prevention measures in remote communities. 相似文献
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Proteases are candidate biomarkers and therapeutic targets for many diseases. Sensitive and robust techniques are needed to quantify proteolytic activities within the complex biological milieu. We hypothesized that a combinatorial protease substrate library could be used effectively to identify similarities and differences between serum and bronchoalveolar lavage fluid (BALF), two body fluids that are clinically important for developing targeted therapies and diagnostics. We used a concise library of fluorogenic probes to map the protease substrate specificities of serum and BALF from guinea pigs. Differences in the proteolytic fingerprints of the two fluids were striking: serum proteases cleaved substrates containing cationic residues and proline, whereas BALF proteases cleaved substrates containing aliphatic and aromatic residues. Notably, cleavage of proline-containing substrates dominated all other protease activities in both human and guinea pig serum. This substrate profiling approach provides a foundation for quantitative comparisons of protease specificities between complex biological samples. 相似文献
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Balachandran S Gadekar PK Parkale S Yadav VN Kamath D Ramaswamy S Sharma S Vishwakarma RA Dagia NM 《Bioorganic & medicinal chemistry letters》2011,21(5):1508-1511
Two series of novel furan and indole compounds were synthesized and probed for inhibition of macrophage migration inhibitory factor (MIF) activity. Several compounds from both series inhibited the enzymatic activity of MIF at levels equal to or significantly better than ISO-1 (an early MIF inhibitor). The majority of the compounds that robustly inhibited the spontaneous secretion/release/recognition of MIF from freshly isolated human peripheral blood mononuclear cells were from the furan series (compounds 5, 9, 13, 15, and 16). In contrast, compounds that markedly inhibited the MIF-induced production of pro-inflammatory cytokines were predominantly from the indole series (compounds 26, 29, and 32). 相似文献
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Andreas Dräger Michel Dumontier Andrew Finney Martin Golebiewski Janna Hastings Stefan Hoops Sarah Keating Douglas B Kell Samuel Kerrien James Lawson Allyson Lister James Lu Rainer Machne Pedro Mendes Matthew Pocock Nicolas Rodriguez Alice Villeger Darren J Wilkinson Sarala Wimalaratne Camille Laibe Michael Hucka Nicolas Le Novère 《Molecular systems biology》2011,7(1)
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Lise Grout Isabel Martinez-Pino Iza Ciglenecki Sakoba Keita Alpha Amadou Diallo Balla Traore Daloka Delamou Oumar Toure Sarala Nicholas Barbara Rusch Nelly Staderini Micaela Serafini Rebecca F. Grais Francisco J. Luquero 《PLoS neglected tropical diseases》2015,9(12)