全文获取类型
收费全文 | 8249篇 |
免费 | 729篇 |
出版年
2023年 | 79篇 |
2022年 | 156篇 |
2021年 | 323篇 |
2020年 | 187篇 |
2019年 | 237篇 |
2018年 | 273篇 |
2017年 | 233篇 |
2016年 | 368篇 |
2015年 | 565篇 |
2014年 | 544篇 |
2013年 | 662篇 |
2012年 | 783篇 |
2011年 | 719篇 |
2010年 | 459篇 |
2009年 | 348篇 |
2008年 | 487篇 |
2007年 | 426篇 |
2006年 | 376篇 |
2005年 | 331篇 |
2004年 | 306篇 |
2003年 | 265篇 |
2002年 | 235篇 |
2001年 | 37篇 |
2000年 | 24篇 |
1999年 | 37篇 |
1998年 | 60篇 |
1997年 | 34篇 |
1996年 | 30篇 |
1995年 | 26篇 |
1994年 | 23篇 |
1993年 | 26篇 |
1992年 | 10篇 |
1991年 | 18篇 |
1990年 | 15篇 |
1989年 | 11篇 |
1988年 | 11篇 |
1987年 | 20篇 |
1986年 | 12篇 |
1985年 | 19篇 |
1984年 | 22篇 |
1983年 | 19篇 |
1982年 | 17篇 |
1981年 | 9篇 |
1980年 | 11篇 |
1979年 | 15篇 |
1978年 | 11篇 |
1977年 | 9篇 |
1976年 | 9篇 |
1974年 | 9篇 |
1972年 | 10篇 |
排序方式: 共有8978条查询结果,搜索用时 312 毫秒
111.
Xiyan Xiong Sara L. Loo Li Zhang Mark M. Tanaka 《Proceedings. Biological sciences / The Royal Society》2021,288(1942)
The human gut microbiota is transmitted from mother to infant through vaginal birth and breastfeeding. Bifidobacterium, a genus that dominates the infants’ gut, is adapted to breast milk in its ability to metabolize human milk oligosaccharides; it is regarded as a mutualist owing to its involvement in the development of the immune system. The composition of microbiota, including the abundance of Bifidobacteria, is highly variable between individuals and some microbial profiles are associated with diseases. However, whether and how birth and feeding practices contribute to such variation remains unclear. To understand how early events affect the establishment of microbiota, we develop a mathematical model of two types of Bifidobacteria and a generic compartment of commensal competitors. We show how early events affect competition between mutualists and commensals and microbe-host-immune interactions to cause long-term alterations in gut microbial profiles. Bifidobacteria associated with breast milk can trigger immune responses with lasting effects on the microbial community structure. Our model shows that, in response to a change in birth environment, competition alone can produce two distinct microbial profiles post-weaning. Adding immune regulation to our competition model allows for variations in microbial profiles in response to different feeding practices. This analysis highlights the importance of microbe–microbe and microbe–host interactions in shaping the gut populations following different birth and feeding modes. 相似文献
112.
Anaya-Ramos Laura Díaz-Ruíz Araceli Ríos Camilo Mendez-Armenta Marisela Montes Sergio Aguirre-Vidal Yoshajandith García-Jiménez Sara Baron-Flores Veronica Monroy-Noyola Antonio 《Biometals》2021,34(6):1295-1311
BioMetals - Thallium (TI) is one of the most toxic heavy metals. Human exposure to Tl occurs through contaminated drinking water and from there to food, a threat to health. Recently, environmental... 相似文献
113.
Castro Gabriel Vaisam Latorre Ana Frederica Sutter Korndorfer Fabíola Pozza de Carlos Back Lia Kubelka Lofgren Sara Emelie 《Biochemical genetics》2021,59(6):1666-1679
Biochemical Genetics - Obesity and overweight are worldwide public health problems with an evident genetic predisposition that is still poorly understood. In addition, great variability has been... 相似文献
114.
Manuele Gori Sara Maria Giannitelli Andrea Zancla Pamela Mozetic Marcella Trombetta Nicol Merendino Alberto Rainer 《Biotechnology and bioengineering》2021,118(1):142-152
Organs‐on‐chip (OoCs) are catching on as a promising and valuable alternative to animal models, in line with the 3Rs initiative. OoCs enable the creation of three‐dimensional (3D) tissue microenvironments with physiological and pathological relevance at unparalleled precision and complexity, offering new opportunities to model human diseases and to test the potential therapeutic effect of drugs, while overcoming the limited predictive accuracy of conventional 2D culture systems. Here, we present a liver‐on‐a‐chip model to investigate the effects of two naturally occurring polyphenols, namely quercetin and hydroxytyrosol, on nonalcoholic fatty liver disease (NAFLD) using a high‐content analysis readout methodology. NAFLD is currently the most common form of chronic liver disease; however, its complex pathogenesis is still far from being elucidated, and no definitive treatment has been established so far. In our experiments, we observed that both polyphenols seem to restrain the progression of the free fatty acid‐induced hepatocellular steatosis, showing a cytoprotective effect due to their antioxidant and lipid‐lowering properties. In conclusion, the findings of the present work could guide novel strategies to contrast the onset and progression of NAFLD. 相似文献
115.
116.
117.
118.
119.
120.