排序方式: 共有65条查询结果,搜索用时 0 毫秒
61.
62.
Shaolin Ma Michael H. McGuire Lingegowda S. Mangala Sanghoon Lee Elaine Stur Wen Hu Emine Bayraktar Alejandro Villar-Prados Cristina Ivan Sherry Y. Wu Akira Yokoi Santosh K. Dasari Nicholas B. Jennings Jinsong Liu Gabriel Lopez-Berestein Prahlad Ram Anil K. Sood 《Cell reports》2021,34(6):108726
- Download : Download high-res image (201KB)
- Download : Download full-size image
63.
64.
Subrata Batabyal Sanghoon Kim Weldon Wright Samarendra Mohanty 《Journal of biophotonics》2021,14(1):e202000234
Delivery of therapeutic genes into retina is proving to reverse degeneration and restore vision, however, viral vector-based gene delivery is prone to immunorejection, inflammatory/immune-response and nontargeted. Here, we report nonviral gene delivery and expression of opsin encoding genes in mouse retina in-vitro and in-vivo by use of pulsed femtosecond laser microbeam. In-vitro patch-clamp recording of the opsin-sensitized retinal cells and visually evoked in-vivo electrical recording from laser-transfected eye of mouse with degenerated retina showed functional response. The ultrafast laser-based naked gene delivery showed minimal damage and reliable expression of therapeutic opsin in cell membrane of the selected cells and in targeted retinal region. Laser-based “naked DNA gene therapy” in a spatially targeted manner will pave the way for treatment of inherited retinal diseases. 相似文献
65.
Kim Geon A Lee Eun Mi Cho Bumrae Alam Zahid Kim Su Jin Lee Sanghoon Oh Hyun Ju Hwang Jong Ik Ahn Curie Lee Byeong Chun 《Transgenic research》2019,28(1):91-102
Transgenic Research - Herein, we successfully generated transgenic pigs expressing both soluble human tumor necrosis factor receptor I IgG1-Fc (shTNFRI-Fc) and human hemagglutinin (HA)-tagged-human... 相似文献