Effect of hyperthermia on growth of Ehrlich ascites tumor cells

Hyperthermic treatment at 43 degrees C suppressed the growth of Ehrlich ascites tumor (EAT) cells in vitro. Incubation of EAT cells at 43 degrees C for as little as 1.5 h totally abolished the transplantability of the tumor. At the same time, the rate of cellular glucose uptake, the density of glucose transporter on the cells as well as the extent of thymidine, uridine and leucine incorporation were significantly reduced.     

Polarizing activity in the developing limb of the Syrian hamster.

The transplantation of small pieces of tissue from the limb buds of 9 1/2 -10 day hamster embryos to the wing bud of the chick results in the induction of supernumerary wing structures. The anteroposterior polarity of these induced structures is under the control of the transplanted hamster tissue. The developing hamster limb thus has limb polarizing activity similar to that found in avian species and, as in the chick, the activity is found primarily in the posterior region of the limb bud.     

Cellular immunity in pyelonephritis: inhibition of the spleen cell response to the mitogen concanavalin A

Spleen cells from rats given experimental pyelonephritis using Escherichia coli and Proteus mirabilis as infecting organisms were evaluated for their ability to respond to the mitogen Concanavalin A. Results indicate an 80% reduction in the response of animals with gross suppuration in the kidney, but no inhibition is observed in animals with kidney infection, but not renal abscesses. The inhibition is not, apparently, due to serum factors.