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61.
Zargaran Fatemeh Nemati Akya Alisha Rezaeian Shahab Ghadiri Keyghobad Lorestani Roya Chegene Madanchi Hamid Safaei Sadegh Rostamian Mosayeb 《International journal of peptide research and therapeutics》2021,27(2):875-886
International Journal of Peptide Research and Therapeutics - Klebsiella pneumoniae is one of the major causes of nosocomial infections worldwide which can cause several diseases in children and... 相似文献
62.
Abdollah Jafarzadeh Maryam Nemati Najmeh Aminizadeh Neelam Bodhale Arup Sarkar Sara Jafarzadeh Iraj Sharifi Bhaskar Saha 《PLoS pathogens》2022,18(8)
As effector innate immune cells and as a host to the protozoan parasite Leishmania, macrophages play a dual role in antileishmanial immunoregulation. The 2 key players in this immunoregulation are the macrophage-expressed microRNAs (miRNAs) and the macrophage-secreted cytokines. miRNAs, as small noncoding RNAs, play vital roles in macrophage functions including cytokines and chemokines production. In the reverse direction, Leishmania-regulated cytokines alter miRNAs expression to regulate the antileishmanial functions of macrophages. The miRNA patterns vary with the time and stage of infection. The cytokine-regulated macrophage miRNAs not only help parasite elimination or persistence but also regulate cytokine production from macrophages. Based on these observations, we propose a novel immunoregulatory framework as a scientific rationale for antileishmanial therapy. 相似文献
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Houshang Nemati Reza Khodarahmi Ameneh Rahmani Ali Ebrahimi Mojtaba Amani Kamran Eftekhari 《Cell biochemistry and function》2013,31(1):36-40
Psoriasis is a chronic inflammatory skin disease characterized by excessive cellular replication. Apolipoproteins are genetically determined molecule whose role has been implied in cardiovascular pathology. Vascular adhesion protein?1 (VAP?1) is an adhesion molecule with an enzymatic activity that partakes in the migration process of lymphocytes into sites of inflammation. Our purpose was to evaluate the plasma lipid profiles, apolipoproteins (A1, B) and Lp (a) and VAP?1 in order to compare the lipid profile in psoriatic patients with non‐affected persons and correlation between VAP?1 and Lp (a). We determined serum concentrations of lipids, lipoproteins , apolipoproteins and VAP?1 in 90 patients with psoriasis and 90 age matched controls. Serum Lp (a), apo A1 and apo B were measured by immunoprecipitation assays, and the lipids and lipoproteins were measured by enzymatic methods.The VAP?1 were masured by ELISA method. The mean levels of total cholesterol, LDL, apo B and VAP?1 in patients with psoriasis were found to be significantly higher than those of healthy subjects (P<0.05. In psoriatic patients, elevation of VAP‐1 correlated with elevation of Lp (a) (p = 0.025). This study shows that high serum lipid level and VAP?1, is significantly more common in psoriasis. This fact may be responsible for higher prevalence of cardiovascular accident in psoriatic patients. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited disease, which causes neonatal hemolytic anemia and jaundice. Recent studies of our group showed that the Mediterranean variant of this enzyme (Gd-Md) is the predominant G6PD in Iranian male infants suffering from jaundice; this variant is classified as severe G6PD deficiency. Considering the importance of G6PD reaction and its products NADPH and glutathione (GSH) against oxidative stress, we hypothesized the failure of detoxification of H(2)O(2) in G6PD-deficient white blood cells that could probably induce primary DNA damage. For the evaluation of DNA damage, we analyzed mononuclear leukocytes of 36 males suffering from the Gd-Md deficiency using alkaline single cell gel electrophoresis (SCGE) or comet assay. The level of DNA damage was compared with the level of basal DNA damage in control group represented by healthy male infant donors (of the same age group). Visual scoring was used for the evaluation of DNA damages. The results showed that the mean level of the DNA strand breakage in mononuclear leukocytes of 36 male G6PD-deficient (Gd-Md) infants was significantly higher (P < 0.001) than those observed in the normal lymphocytes. In conclusion, this investigation indicates that the mononuclear leukocytes of the Gd-Md samples may be exposed to DNA damage due to oxidative stress. This is the first report using comet assay for evaluation of DNA damage in severe G6PD deficiency samples. 相似文献
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Samimi Mansooreh Dadkhah Adeleh Haddad Kashani Hamed Tajabadi-Ebrahimi Maryam Seyed Hosseini Elahe Asemi Zatollah 《Probiotics and antimicrobial proteins》2019,11(4):1355-1361
Probiotics and Antimicrobial Proteins - Data on the effects of synbiotic supplementation on glycemic control, lipid profiles, and atherogenic index of plasma (AIP) of women with polycystic ovary... 相似文献
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Mostafa M. Amini Amirreza Azadmehr Hamid Reza Khavasi Ali Nemati Kharat 《Inorganica chimica acta》2009,362(2):355-24
The reaction of ethyldiphenyltin(IV) iodide with silver benzoate in ethanol results in the formation of bis(benzoato)ethylphenyltin(IV), EtPhSn[OC(O)C6H5]2 (1), by the cleavage of a phenyl group bound to tin. The reaction of ethyldiphenyltin(IV) iodide with silver acetate provides acetatoethyldiphenyltin(IV), EtPh2SnOC(O)CH3 (2). Similarly, the reaction of diphenylpropyltin(IV) iodide with silver acetate affords acetatodiphenyl-n-propyltin(IV), Ph2PrSnOC(O)CH3 (3). These three complexes were characterized by elemental analysis, mass spectrometry, and infrared spectroscopy (IR), as well as 1H, 13C, and 119Sn NMR. The molecular structures of three complexes were also verified by single-crystal X-ray analyses. The X-ray structures show that 1 adopts a skew-trapezoidal bipyramidal structure, while 2 and 3 are rare, cyclic hexameric structures. 相似文献
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Kassam Karim-Aly Ruelle Morgan Haag Isabell Bulbulshoev Umed Kaziev Daler Louis Leo Ullmann Anna Edwards Iriel Khan Aziz Ali Trabucco Antonio Samimi Cyrus 《Human ecology: an interdisciplinary journal》2021,49(5):509-523
Human Ecology - Seasonal rounds are deliberative articulations of a community’s sociocultural relations with their ecological system. The process of visualizing seasonal rounds informs... 相似文献
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Nemati Zargaran Fatemeh Akya Alisha Ghadiri Keyghobad Ranjbarian Parivash Rostamian Mosayeb 《International journal of peptide research and therapeutics》2021,27(4):2209-2221
International Journal of Peptide Research and Therapeutics - Klebsiella pneumoniae causes various human infections. Ferric enterobactin protein (FepA) is a conserved protein of K. pneumoniae with... 相似文献
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Adsorption of cyanophage AS-1 to unicellular cyanobacteria and isolation of receptor material from Anacystis nidulans. 下载免费PDF全文
Cells of unicellular cyanobacteria of typological group Ia, containing approximately 50 mol% guanine + cytosine (G+C) in their DNA (R. Y. Stanier, R. Kunisawa, M. Mandel, and G. Cohen-Bazire, Bacteriol. Rev. 35:171-205, 1971), were susceptible to infection by the cyanophage AS-1. Cyanobacteria of the same typological group, containing approximately 65 mol% G+C in their DNA, did not adsorb the cyanophage AS-1 or adsorbed it at a low rate. AS-1 was not propagated by any of the investigated strains with a high G+C content in their DNA. However, cells of strains 6907 and 6911 were lysed by cyanophage AS-1. A comparison of the host range of this phage with the lipopolysaccharide composition of host and non-host cell walls suggests that lipopolysaccharides are involved in the adsorption process. About 8 microgram of lipopolysaccharide per ml from host strains inactivated 50% of the particles of a solution containing 100 PFU/ml after 60 min of incubation at 30 degrees C. Material with receptor activity was extracted from the host strain Anacystis nidulans KM. The extract was purified of glycolipids and pigments, and a fraction showing receptor activity was isolated. This fraction contained three polypeptides of molecular weights between 54,000 and 64,000. Heat and protease treatment of whole cells and of isolated receptor material decreased the receptor activity. The fluorescence intensity of A. nidulans cells labeled with 1-anilino-8-naphthalene sulfonate was increased when AS-1 was adsorbed to these cells. The participation of lipopolysaccharides and proteins in the formation of the receptor complex is discussed. 相似文献