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961.
Jukka Bisi Sami Kurki Marko Svensberg Tuija Liukkonen 《European Journal of Wildlife Research》2007,53(4):304-314
The growth of the Finnish wolf (Canis lupus) population during the last years has highlighted people’s contradictory attitudes toward wolves. The supranational conservation
objectives brought on by Finland’s membership in the European Union (EU) and the regional application of the official policy
on wolves have led to conflicts. This article is based on the preparation process of the wolf management plan in Finland.
As a part of the process, a nationwide hearing was arranged in 2004. Fear of wolves is widespread and even more common in
areas with low wolf population. People living in areas where wolves occur feel that they can no longer influence decision
making which affects them and that the authorities, conservationists, and the EU do not listen to their opinions. Numerous
requests have been made for the legislation and its interpretation, and concessions to these requests would promote consensus
and increase tolerance for wolves. Proposed changes include reforming the damage compensation system and formulating a clearer
interpretation of the conservation status of wolves. However, it seems impossible to create a policy that would be universally
supported. As the wolf question has become more central in environmental policy, the conservation and management of the species
have become more complicated, and the cooperation between various interest groups has declined. The wolf conflict could be
mitigated by compromises, but because the conflict is value-based, solutions are illusive. 相似文献
962.
The stem barks of Oricia renieri and O. gabonensis have yielded nine alkaloids, including furoquinolines, acridones, 3,4-pyrano-2-quinolones and a 2-amino-benzophenone. One of the pyranoquinolones isolated from O. renieri, 7-methoxy-N-methylflindersine, is reported for the first time. All alkaloids were identified on the basis of spectral data. The chemotaxonomic significance of the alkaloids of these two species is discussed. 相似文献
963.
Gene diversity (GD), also called polymorphism information content, is a commonly used measure of molecular marker polymorphism. Calculation of GD for dominant markers such as AFLP, RAPD, and multilocus SSRs is valuable for researchers. To meet this need, we developed a free online computer program, GDdom, which provides easy, quick, and accurate calculation of dominant marker GD with a commonly used formula. Results are presented in tabular form for quick interpretation. 相似文献
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Mousavi Seyedeh Zahra Rahmanian Mojdeh Sami Ashkan 《Functional & integrative genomics》2022,22(3):429-433
Functional & Integrative Genomics - Although extrapulmonary manifestations of coronavirus disease 2019 (COVID-19) are increasingly reported, no effective therapeutic strategy for these... 相似文献
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Faisal Thayyullathil Anees Rahman Cheratta Ameer Alakkal Karthikeyan Subburayan Siraj Pallichankandy Yusuf A. Hannun Sehamuddin Galadari 《Cell death & disease》2021,12(1)
Ferroptosis is a type of regulated cell death characterized by ROS accumulation and devastating lipid peroxidation (LPO). The role of acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, in the induction of apoptosis has been studied; however, to date its role in ferroptosis is unclear. In this study, we report that ASM plays a hitherto unanticipated role in promoting ferroptosis. Mechanistically, Erastin (Era) treatment results in the activation of ASM and generation of ceramide, which are required for the Era-induced reactive oxygen species (ROS) generation and LPO. Inhibition of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) or removal of intracellular ROS, significantly reduced Era-induced ASM activation, suggesting that NADPH oxidase-derived ROS regulated ASM-initiated redox signaling in a positive feedback manner. Moreover, ASM-mediated activation of autophagy plays a critical role in ferroptosis inducers (FINs)-induced glutathione peroxidase 4 (GPX4) degradation and ferroptosis activation. Genetic or pharmacological inhibition of ASM diminishes Era-induced features of autophagy, GPX4 degradation, LPO, and subsequent ferroptosis. Importantly, genetic activation of ASM increases ferroptosis in cancer cells induced by various FINs. Collectively, these findings reveal that ASM plays a novel role in ferroptosis that could be exploited to improve pathological conditions that link to ferroptosis.Subject terms: Lipid peroxides, Cancer models, Macroautophagy, Lipid signalling 相似文献
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