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Kamel Ali Saberiyan Mohammadreza Adelian Samaneh Teimori Hossein 《Molecular biology reports》2022,49(10):9365-9372
Molecular Biology Reports - Numerous pieces of evidence show that many environmental and genetic factors can cause male infertility. Much research in recent years has investigated the function of... 相似文献
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Jannat Ali Pour Naghmeh Meshkani Reza Toolabi Karamollah Mohassel Azadi Samaneh Zand Shahabedin Emamgholipour Solaleh 《Molecular biology reports》2020,47(5):3459-3468
Molecular Biology Reports - It is well-established that an impaired adipose tissue function and morphology caused by a dysregulated gene expression contribute substantially to obesity. Nowadays,... 相似文献
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Sara Hosseini Samaneh Hosseini Mohammad Salehi 《Journal of cellular physiology》2020,235(12):9752-9762
Despite encouraging advances in fertility technology, the success rate of an ongoing pregnancy is relatively low and predominantly associated with implantation failure. Inflammatory responses are beneficial in the fetomaternal interface and supposedly accelerate the chances for successful implantation. The current study aims to determine the effect of Toll-like receptor 4 (TLR4) overexpression in mouse blastocysts via Let-7a downregulation using intracytoplasmic sperm injection-sperm-mediated gene transfer on embryo attachment rate. The pLenti-III-GFP-miR-Off-Let-7a vector was transmitted to oocytes derived via in vitro maturation (IVM) and in vivo oocytes by using NaOH-treated spermatozoa. Let-7a and TLR4 expression levels were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR), immunocytochemistry, and western blot analysis in both oocytes and embryos. Blastocyst adhesion on the endometrial cells was monitored by microscopic analysis. qRT-PCR results showed that Let-7a expression decreased in the IVM (GV-MII) oocytes compared to the in vivo oocyte (MII) group (p < .05). TLR4 showed a higher expression in GV-MII oocytes at both the gene and protein levels (p < .05). Following anti-miR-Let-7a transmission, the TLR4 expression level was significantly upregulated in embryos compared with the control groups (p < .05). Attachment and migration of trophoblasts cells towards endometrial cells dramatically increased compared to the control group (p < .05). Based on our results, we concluded that Let-7a might mediate embryo attachment through regulation of TLR4 expression levels. 相似文献
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The Protein Journal - Enteropeptidase is a duodenum serine protease that triggers the activation of pancreatic enzymes by remarkably specific cleavages after lysine residues of peptidyl substrate... 相似文献
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Isolation and identification of chemotherapy‐enriched sphere‐forming cells from a patient with gastric cancer 下载免费PDF全文