全文获取类型
收费全文 | 304篇 |
免费 | 36篇 |
出版年
2018年 | 4篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 10篇 |
2014年 | 7篇 |
2013年 | 8篇 |
2012年 | 10篇 |
2011年 | 11篇 |
2010年 | 17篇 |
2009年 | 8篇 |
2008年 | 12篇 |
2007年 | 17篇 |
2006年 | 20篇 |
2005年 | 12篇 |
2004年 | 8篇 |
2003年 | 4篇 |
2002年 | 11篇 |
2001年 | 3篇 |
2000年 | 9篇 |
1999年 | 7篇 |
1997年 | 5篇 |
1995年 | 3篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 5篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 4篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1975年 | 9篇 |
1974年 | 6篇 |
1973年 | 3篇 |
1972年 | 9篇 |
1971年 | 5篇 |
1970年 | 12篇 |
1969年 | 4篇 |
1968年 | 2篇 |
1967年 | 5篇 |
1965年 | 4篇 |
1964年 | 2篇 |
排序方式: 共有340条查询结果,搜索用时 62 毫秒
141.
Francisco M. Salzano 《Evolution》2011,4(2):199-204
A review was made of studies which considered the prehistoric colonization of the Americas. It included simulation models
based on linguistic and genetic data, archeological and paleoanthropological information, as well as genetic and genomic empirical
results. At the end, two examples of research performed by our group were presented: the first on the association between
the 7R dopamine receptor D4 allele and migration, and the second on the distribution of 11 short tandem repeat loci in 30
South Amerindian populations, relating the pattern found with historical events and language dispersion. 相似文献
142.
Anna M Salzano Ferdinando Febbraio Tiziana Farias Giovanni P Cetrangolo Roberto Nucci Andrea Scaloni Giuseppe Manco 《Microbial cell factories》2007,6(1):25
Background
Exposure to nickel (Ni) and its chemical derivatives has been associated with severe health effects in human. On the contrary, poor knowledge has been acquired on target physiological processes or molecular mechanisms of this metal in model organisms, including Bacteria and Archaea. In this study, we describe an analysis focused at identifying proteins involved in the recovery of the archaeon Sulfolobus solfataricus strain MT4 from Ni-induced stress. 相似文献143.
144.
Claudia E. Thompson Cláudia L. Fernandes Osmar Norberto de Souza Loreta B. de Freitas Francisco M. Salzano 《Journal of molecular modeling》2010,16(5):919-928
The plant alcohol dehydrogenases (ADHs) have been intensively studied in the last years in terms of phylogeny and they have
been widely used as a molecular marker. However, almost no information about their three-dimensional structure is available.
Several studies point to functional diversification of the ADH, with evidence of its importance, in different organisms, in
the ethanol, norepinephrine, dopamine, serotonin, and bile acid metabolism. Computational results demonstrated that in plants
these enzymes are submitted to a functional diversification process, which is reinforced by experimental studies indicating
distinct enzymatic functions as well as recruitment of specific genes in different tissues. The main objective of this article
is to establish a correlation between the functional diversification occurring in the plant alcohol dehydrogenase family and
the three-dimensional structures predicted for 17 ADH belonging to Poaceae, Brassicaceae, Fabaceae, and Pinaceae botanical
families. Volume, molecular weight and surface areas are not markedly different among them. Important electrostatic and pI
differences were observed with the residues responsible for some of them identified, corroborating the function diversification
hypothesis. These data furnish important background information for future specific structure-function and evolutionary investigations. 相似文献
145.
P. Alexandre Kaminski Françoise Norel Nicole Desnoues Anil Kush Giovanni Salzano Claudine Elmerich 《Molecular & general genetics : MGG》1988,214(3):496-502
Summary The fast growing strain, Azorhizobium caulinodans ORS571, isolated from stem nodules of the tropical legume Sesbania rostrata, can grow in the free-living state at the expense of molecular nitrogen. Five point mutants impaired in nitrogen fixation in the free-living state have been complemented by a plasmid containing the cloned fix-ABC region of strain ORS571. Genetic analysis of the mutants showed that one was impaired in fixC, one in fixA and the three others in a new gene, located upstream from fixA and designated nifO. Site-directed Tn5 mutagenesis was performed to obtain Tn5 insertions in fixB and fixC. The four genes are required for nitrogen fixation both in the free-living state and under symbiotic conditions. The nucleotide sequence of nifO was established. The gene is transcribed independently of fixA and does not correspond to fixX, recently identified in Rhizobium meliloti and R. leguminosarum. Biochemical analysis of the five point mutants showed that they synthesized normal amounts of nitrogenase components. It is unlikely that fixA, fixC and nifO are involved in electron transport to nitrogenase. FixC could be required for the formation of a functional nitrogenase component 2. 相似文献
146.
147.
148.
149.
150.
Salzano M Marabotti A Milanesi L Facchiano A 《Biochemical and biophysical research communications》2011,(2):176-181
Molecular structure of the ligand binding domain of hAhR has been modelled by homology modelling techniques and used for docking simulations with dioxin and nine more xenobiotics and endogenous ligands. The study evidences that different sites may bind these ligands, whereas only one binding site has been previously indicated by past studies on the mouse homologous receptor. The differences in the sequence of mouse and human AhR ligand binding domain may explain this observation, being most of them in the additional sites observed. Preferences of the evaluated ligands for the different sites are reported and discussed in view of their functional role. 相似文献