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In the female hamster, temporary sterility for a period of 10 or 15 days was induced by an intraperitoneal Silastic-PVP-tube containing 0.5 or 1.0 mg of PGF2α, respectively. All Silastic-PVP-PGF2α tube bearing animals regained fertility and delivered normal litters at various times after the placement of the tube. The release rate of 3H-PGF2α from the Silastic-PVP tube was described and their potential use as a drug delivery system discussed. 相似文献
353.
Till Bey Suraj Jamge Sonja Klemme Dorota Natalia Komar Sabine Le Gall Pawel Mikulski 《Epigenetics》2016,11(8):625-634
In January 2016, the first Epigenetic and Chromatin Regulation of Plant Traits conference was held in Strasbourg, France. An all-star lineup of speakers, a packed audience of 130 participants from over 20 countries, and a friendly scientific atmosphere contributed to make this conference a meeting to remember. In this article we summarize some of the new insights into chromatin, epigenetics, and epigenomics research and highlight nascent ideas and emerging concepts in this exciting area of research. 相似文献
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Using cloning andin vitro protein synthesis we identified the polypeptide product of thetetP gene ofClostridium perfringens which is responsible for conferring resistance to tetracycline. TwoEcoRI fragments invariably share the resistance determinant in all of theClostridium perfringens isolates that we studied. Likewise, two proteins of 10 and 20 kDa were found to be conserved in all of the recombinant clones.
The 10 kDa protein appears to be responsible for the constitution of the expression oftetP gene inC. perfringens. 相似文献
357.
Suraj Konnath George Veronica Tovar-Sepulveda Steven S Shen Weiguo Jian Yiqun Zhang Susan G Hilsenbeck Seth P Lerner Carolyn L Smith 《Translational oncology》2013,6(3):244-255
Bladder cancer is the fifth most frequent tumor in men and ninth in women in the United States. Due to a high likelihood of recurrence, effective chemoprevention is a significant unmet need. Estrogen receptors (ERs), primarily ERβ, are expressed in normal urothelium and urothelial carcinoma, and blocking ER function with selective ER modulators such as tamoxifen inhibits bladder cancer cell proliferation in vitro. Herein, the chemoprotective potential of tamoxifen was evaluated in female mice exposed to the bladder-specific carcinogen, N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). Carcinogen treatment resulted in a 76% tumor incidence and increased mean bladder weights in comparison to controls. In contrast, mice receiving tamoxifen concurrent (8–20 weeks) or concurrent and subsequent (8–32 weeks) to BBN administration had no change in bladder weight and only 10% to 14% incidence of tumors. Non-muscle-invasive disease was present in animals treated with tamoxifen before (5–8 weeks) or after (20–32 weeks) BBN exposure, while incidence of muscle-invasive bladder carcinoma was reduced. ERβ was present in all mice and thus is a potential mediator of the tamoxifen chemoprotective effect. Surprisingly, ERα expression, which was detected in 74% of the mice exposed to BBN alone but not in any controlmice, was correlated with tumor incidence, indicating a possible role for this receptor in carcinogen-induced urothelial tumorigenesis. Thus, these data argue that both ERα and ERβ play a role in modulating carcinogen-induced bladder tumorigenesis. Administration of tamoxifen should be tested as a chemopreventive strategy for patients at high risk for bladder cancer recurrence. 相似文献