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271.
K Sainio A Raatikainen-Ahokas 《The International journal of developmental biology》1999,43(5):435-439
Mesonephros is a vestige, transient renal organ that functions only during embryonic development. The anatomy, position and even cellular fate of the mesonephric kidney varies drastically among mammalian species. The origin of mesonephros from intermediate mesoderm and the dependence of its differentiation on the nephric or Wolffian duct have been well established. Commonly accepted is also the mesonephric origin of epididymal ducts of the male reproductive tract. Recently, upon the more profound understanding of the molecular mechanisms involved in the development of the permanent mammalian kidney, some light has been shed over the molecular events taking place during the mesonephric development as well. Because of the functional and structural similarities between the mesonephric and metanephric kidneys, it is not surprising that many molecules regulating metanephric development are also activated during mesonephric development. However, the multifunctional nature of mesonephros has been unexpected. First, it serves as an embryonic secretory organ, in some mammalian species more so than in others. It is thereafter removed by programmed cell death. Second, it is a source of multiple stem cells including somatic cells in the male gonad, vascular endothelial cells, and hematopoietic stem cells. Thus, mesonephros is a challenging model for studies on epithelial differentiation and organogenesis, regulation of apoptosis, sex determination and stem cell differentiation. In this review, we focus in the molecular and stem cell aspects in the differentiation of the mammalian mesonephros. 相似文献
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Yu-Chia Chen Madhusmita Priyadarshini Pertti Panula 《Histochemistry and cell biology》2009,132(4):375-381
Tyrosine hydroxylase (TH) is a rate-limiting enzyme in the biosynthesis of catecholamines. In zebrafish, two genes encoding
TH have been identified. We cloned them and studied their expression in zebrafish. In adult tissues, th1 mRNA was more abundant than th2 mRNA in the brain and eyes, whereas th2 mRNA was more abundant in the liver, kidney, heart and gills. In developing brain, th1 mRNA was readily detected at 1 day post-fertilization using qPCR and in situ hybridization, whereas th2 mRNA appeared later. th1 was found in 17 catecholaminergic groups in larval brain, whereas th2 was found in four additional groups. A monoclonal antibody commonly used against TH detected preferentially TH1 protein.
The two th genes, probably originated as a result of genome duplication, thus show complementary expression, although th1 is predominant in the brain and th2 in the periphery. th2 may be a novel essential factor in regulation of catecholamine synthesis in zebrafish. 相似文献
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Morphological variation of Keratella cochlearis (Gosse) s.l.were monitored during two years in one eutrophic pond in centralFinland. Nine different taxonomical forms were found duringthe observations. Very significant negative correlation wasfound between water temperature and total length of tecta series.Some forms (forms of hispida series and irregularis series)were found only during warm water seasons. The lorica structureof different morphs was also studied by SEM techniques and besidesin the plaque patterns, differences were found among pustulationand pustule structure of different types. 相似文献