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The effects of tricyclohexyltin hydroxide (Plictran), an organotin acaricide, on 45Ca2+ uptake and Ca2+ ATPase were studied in vitro and in vivo in rat heart ventricular membrane vesicles, primarily sarcoplasmic reticulum. There was a concentration dependent inhibition of both 45Ca2+ uptake and Ca2+ ATPase in vivo as well as in vitro. Isoproterenol, a beta-adrenergic agonist, stimulated 45Ca2+ uptake and Ca2+ ATPase of sarcoplasmic reticulum and this was also inhibited by Plictran. Since cardiac relaxation is mediated by beta-adrenergic stimulation via Ca+ uptake by sarcoplasmic reticulum, the inhibition of calcium pump activity by Plictran may result in alterations in cardiac Ca2+ fluxes leading to cardiac dysfunction. 相似文献
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I. Kabeer Ahammad Sahib K. S. Jagannatha Rao K. V. Ramana Rao 《Journal of biosciences》1981,3(1):17-21
Exposure of fish to a sublethal (2 mg/litre/48h) concentration of malathion showed no significant changes in any of the physical
parameters investigated like, body weight and body water content, while the oxygen consumption of the fish showed a consistent
increase upto 24 h and later declined to 8% suggesting the reduction of oxidative metabolism at the end of 48 h. The sodium,
potassium and calcium ions showed a remarkable decrease in all the tissues of malathion-exposed fish, suggesting the loss
of ions from the body of these fish. The results suggested that the regulation of osmotic balance may occur by an effective
operation of the salt pump rather than the water pump. 相似文献