Genetic and Molecular Characterization of New Natural Haplotype t wMP1 Found in House Mouse Mus domesticus R. from Peru

A new natural haplotype, t ^wMP1, found in a population of house mouse Mus domesticus from Peru, was subjected to genetic and molecular analyses. Experiments were performed to study the complementation of the new haplotype, fertility of t ^wMP1/t ^x heterozygotes, and transmission ratio distortion (TRD) of the t-carrying chromosome in the progeny of heterozygous males. Molecular analysis included blot hybridization with t-specific probes Tu48, Tu66, and Tu119. The results were collated with the structure and properties of the t complex, and the new haplotype was identified as a complete lethal one.