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Louis J. Holtzhausen Sofiane Souissi Omar Al Sayrafi Awartani May Abdulaziz Farooq Catharina C. Grant Vasileios Korakakis Safia Rabia Souhaila Segers Karim Chamari 《Biology of sport / Institute of Sport》2021,38(1):129
The aim was to create a Modern Standard Arabic SCAT5 version for different Arabic dialects. This translation and cross-cultural adaptation was performed in eight stages: initial translations, reconciliation of translations and cultural adaptation, back translation, appraisal of back translations, validation of the translation, review and adjustment by reconciliation committee, pretesting in 12 football players and document finalisation. As an alternative to the problematic Months In Reverse Order Test (MIROT) in Arabic, the Serial 3s test (32 Arabic and 30 English participants), the Days of the Week Backwards test (DWBT), and the ‘Adding Serial 3s’ test were tested (30 English and 30 Arabic participants) for accuracy, difficulty and time of completion. The Arabic SCAT5 was similar and comparable to the original English version (7-point Likert scales =< 2). Testing of the pre-final version of the Arabic SCAT5 took 20.4 (SD 3.4) and 17.7 (SD 3.0) minutes respectively to complete and was found acceptable in terms of clarity, understandability, grammatical correctness and coherence. The Arabic Serial 3s test (subtraction version) was unsuitable due to high completion time, low pass rate and high difficulty perception [time = 47.2 (SD 28.0) s; accuracy = 55.2%; difficulty = 3.2 (SD 1.1)]. The Arabic DWBT was too fast and undemanding for concentration testing [time = 4.6 (SD 1.5) s; accuracy = 90%; difficulty = 1.1 (SD 0.3)]. The Adding Serial 3s tests produced similar completion times [18.4 (SD 6.8) vs. 21.1 (SD 5.3), p = 0.088], accuracy (100%) and self-rated difficulty [English = 2.0 (SD 0.7) vs. Arabic-speaking participants = 2.1 (SD 0.8), p = 0.512] and was therefore adopted to replace the MIROT. This culturally adapted Arabic-SCAT5 questionnaire is the first concussion assessment tool available for Arabic-speaking healthcare providers and athletes. Sport Concussion Assessment Tool 5 (SCAT5). Biol Sport. 2021;38(1):129–144. 相似文献
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Paul G. Whitney Eva B?r Fabiola Osorio Neil C. Rogers Barbara U. Schraml Safia Deddouche Salomé LeibundGut-Landmann Caetano Reis e Sousa 《PLoS pathogens》2014,10(7)
Host protection from fungal infection is thought to ensue in part from the activity of Syk-coupled C-type lectin receptors and MyD88-coupled toll-like receptors in myeloid cells, including neutrophils, macrophages and dendritic cells (DCs). Given the multitude of cell types and receptors involved, elimination of a single pathway for fungal recognition in a cell type such as DCs, primarily known for their ability to prime T cell responses, would be expected to have little effect on innate resistance to fungal infection. Here we report that this is surprisingly not the case and that selective loss of Syk but not MyD88 in DCs abrogates innate resistance to acute systemic Candida albicans infection in mice. We show that Syk expression by DCs is necessary for IL-23p19 production in response to C. albicans, which is essential to transiently induce GM-CSF secretion by NK cells that are recruited to the site of fungal replication. NK cell-derived-GM-CSF in turn sustains the anti-microbial activity of neutrophils, the main fungicidal effectors. Thus, the activity of a single kinase in a single myeloid cell type orchestrates a complex series of molecular and cellular events that underlies innate resistance to fungal sepsis. 相似文献
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Nadeem Ahmad Ansari Moinuddin Abdul Rouf Mir Safia Habib Khursheed Alam Asif Ali Rizwan Hasan Khan 《Cell biochemistry and biophysics》2014,70(2):857-865
In diabetes, protein glycation mostly occurs at intrachain lysine residues resulting in the formation of early stage Amadori products which are finally converted to advance glycation end products (AGEs). Several studies have reported autoantibodies against AGEs in diabetes but not much data are found in respect of Amadori products. In this study, poly-l-lysine (PLL) was glycated with 50 mM glucose and the resultant Amadori products were estimated by fructosamine or nitroblue tetrazolium assay. We report high content of Amadori products in PLL upon glycation. Glycated PLL showed marked hyperchromicity in the UV spectrum, ellipticity changes in CD spectroscopy, and variations in ε-methylene protons shift in NMR. It was better recognized by autoantibodies in type 2 diabetics compared to the native PLL. Induced antibodies against glycated PLL were successfully used to probe early glycation in the IgG isolated from diabetes type 2 patients. Role of Amadori products of glycated proteins in the induction of autoantibodies in type 2 diabetes as well as in associated secondary complications has been discussed. 相似文献
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Decolorization of Acid red 151 by Aspergillus niger SA1 under different physicochemical conditions 总被引:1,自引:0,他引:1
Naeem Ali Ikramullah Ghosia Lutfullah Abdul Hameed Safia Ahmed 《World journal of microbiology & biotechnology》2008,24(7):1099-1105
The fungal strain A. niger SA1 isolated from textile wastewater pond proved to be an important source of remediation (decolorization/degradation) for
textile dye, AR 151 (Reactive diazo dye) under different physicochemical conditions. Decolorization assays of AR 151 were
carried out in Simulated textile effluent under shake flask condition for 8 days. Decolorization (at 20 mg l−1 of dye) and related biomass production overall decreased with increase in pH from 5 to 9, at 30°C. It was maximum (95.71%)
at pH 5 with highest amount of three residual products (36.91 (α-naphthol = 5.72) (sulfanilic acid = 24.81) (aniline = 6.38))
besides 2.05 mg ml−1 of biomass production at an optimum concentration 6 and 0.1 mg l−1 of glucose and urea respectively. The formation of the three products followed a quite different pattern at different pH
values, however, it was considerably low (Total = 2.81 mg l−1) compared to the amount of decolorization (67.26%) at pH 8. Decolorization (95–97%) was most favored under mesophilic temperature
(25–45°C). It increased i.e., 90–98% with subsequent increase in dye from 10 to 100 mg l−1, kept ≥50% below 400 mg l−1 and drastically declined to 17% at 500 mg l−1 of dye. Apparently, decolorization is found to be associated with fungal growth and hyphal uptake mechanism (Biosorption/Bioadsorption),
however, mineralization of AR 151 and related products under different operational conditions also suggested a metabolically
mediated decolorization/degradation. 相似文献
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Landers Catherine C. Rabeler Christina A. Ferrari Emily K. D’Alessandro Lia R. Kang Diana D. Malisa Jessica Bashir Safia M. Carone Dawn M. 《Chromosoma》2021,130(1):75-90
Chromosoma - Within the pericentric regions of human chromosomes reside large arrays of tandemly repeated satellite sequences. Expression of the human pericentric satellite HSATII is prevented by... 相似文献
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S. D. Kholkute Rachel Joseph Usha M. Joshi Safia R. Munshi 《Primates; journal of primatology》1981,22(3):399-403
Sixty-two menstrual cycles were observed in five bonnet monkeys over a period of 12 months. The menstrual cycles ranged in
length from 22 to 35 days, although cycles of from 26 to 29 days were most frequent. Menstrual flow occurred for two to seven
days, the flow lasting for three to four days in the majority (82%) of the cycles. Serum estradiol-17β (E2) and progesterone (P) were measured by radioimmunoassay in two consecutive cycles in each monkey and correlated with changes
in the quantity of cervical mucus secretion and spinnbarkeit. The day of the estradiol peak was considered as day 0. The E2 levels began to rise one to three days before the peak, returning to baseline levels within two days and thereafter remained
at low levels. The serum P rose 2 days after the E2 peak, and maximum level was attained at 10 to 12 days after the E2 peak. The quantity of cervical mucus increased proportionately with estrogen. However, the quantity remained at maximum levels
even after the decline of the serum E2 level. Similar trends were observed with the spinnbarkeit. 相似文献
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Stephan Köhler Safia Ouahrani-Bettache 《Journal of enzyme inhibition and medicinal chemistry》2017,32(1):683-687
Carbonic anhydrases have started to emerge as new potential antibacterial targets for several pathogens. Two β-carbonic anhydrases, denominated bsCA I and bsCA II, have been isolated and characterized from the bacterial pathogen Brucella suis, the causative agent of brucellosis or Malta fever. These enzymes have been investigated in detail and a wide range of classical aromatic and heteroaromatic sulfonamides as well as carbohydrate-based compounds have been found to inhibit selectively and efficiently Brucella suis carbonic anhydrases. Inhibition of these metalloenzymes constitutes a novel approach for the potential development of new anti-Brucella agents. This review aims at discussing the recent literature on this topic. 相似文献