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Fatemeh Fotouhi Mostafa Salehi-Vaziri Behrokh Farahmand Ehsan Mostafavi Mohammad Hassan Pouriayevali Tahmineh Jalali Vahideh Mazaheri Mona Sadat Larijani Mahsa Tavakoli Azita Eshratkhah mohammadnejad Neda Afzali Afsaneh Zokaei SeyedeAtefe Hosseini Mohamad Mahdi Mortazavipour FaridehNiknam Oskouei Amitis Ramezani 《Microbes and infection / Institut Pasteur》2021,23(4-5):104810
SARS-CoV-2 as a new global threat has affected global population for one year. Despite the great effort to eradicate this infection, there are still some challenges including different viral presentation, temporal immunity in infected individuals and variable data of viral shedding. We studied 255 COVID-19 suspected individuals to assess the viral shedding duration and also the antibody development against SARS-CoV-2 among the cases. Real Time RT-PCR assay was applied to determine the virus presence and SARS-CoV-2 antibodies were evaluated using SARS-CoV-2 IgM and IgG kits. 113 patients were confirmed for COVID-19 infection. The patients were followed until negative PCR achieved. The median viral shedding among studied population was obtained 34.16 (±17.65) days which was not significantly associated with age, sex and underlying diseases. Shiver and body pain were found in prolonged form of the infection and also patients who had gastrointestinal problems experienced longer viral shedding. Moreover, IgG was present in 84% of patients after 150 days. According to this data, the median viral shedding prolongation was 34.16 days which indicates that 14 days isolation might not be enough for population. In addition, IgG profiling indicated that it is persistent in a majority of patients for nearly 6 months which has brought some hopes in vaccine efficacy and application. 相似文献
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Naderi S Meshram M Wei C McConkey B Ingalls B Budman H Scharer J 《Biotechnology progress》2011,27(5):1197-1205
A metabolic flux based methodology was developed for modeling the metabolism of a Chinese hamster ovary cell line. The elimination of insignificant fluxes resulted in a simplified metabolic network which was the basis for modeling the significant metabolites. Employing kinetic rate expressions for growing and non-growing subpopulations, a logistic model was developed for cell growth and dynamic models were formulated to describe culture composition and monoclonal antibody (MAb) secretion. The model was validated for a range of nutrient concentrations. Good agreement was obtained between model predictions and experimental data. The ultimate goal of this study is to establish a comprehensive dynamic model which may be used for model-based optimization of the cell culture for MAb production in both batch and fed-batch systems. 相似文献
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Azita Zadeh-Vakili Fahimeh Ramezani Tehrani Maryam Sadat Daneshpour Maryam Zarkesh Navid Saadat Fereidoun Azizi 《Gene》2013
Aims
Polycystic ovary syndrome (PCOS), a common female endocrine disorder, represents a wide range of clinical manifestations and disease severity. Recent studies suggest an association between gene variants involved in vitamin D metabolism and common metabolic disturbances in PCOS. We aimed to examine the association of vitamin D receptor (VDR) gene variant with PCOS susceptibility and the severity of disease phenotype.Methods
All participants, including 260 PCOS women (cases) and 221 normoovulatory women (controls), were recruited from a reproductive endocrinology clinic. Cases were divided into the severe and mild PCOS phenotype groups, based on their clinical and paraclinical features. An adenosine to guanine single nucleotide polymorphism of VDR gene (rs757343) was genotyped using the PCR–RFLP method.Results
Distributions of genotypes and alleles did not differ between cases and controls, indicating that this SNP is not associated with increased risk for PCOS. However, this SNP was found to be associated with the severity of the PCOS phenotype. In particular, presence of the A allele is associated with a 74% increased risk of severe phenotype development (OR, 1.74; 95% CI, 1.07–2.82).Conclusion
The genetic variant of the VDR was found to have an association with severity of clinical features of PCOS, but none with disease risk. 相似文献56.
Aghajani Mohammad Hajijafari Mohammad Akbari Hossein Asgarian Fatemeh Sadat 《Sleep and biological rhythms》2020,18(3):209-215
Sleep and Biological Rhythms - The purpose of this study was to assess the validity and reliability of the Persian version of the Cleveland Adolescent Sleepiness Questionnaire (CASQ) in Iranian... 相似文献
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Toghraie Fatemeh Sadat Ghaderi Abbas Ramezani Amin 《International journal of peptide research and therapeutics》2020,26(1):43-51
International Journal of Peptide Research and Therapeutics - Granulocyte colony-stimulating factor (G-CSF) is known as the major mediator of granulopoiesis. However, overexpression of G-CSF has... 相似文献
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Ghodrati Atefe Firoozpour Loghman Balalaie Saeed Hosseini Faezeh Sadat Ramezanpour Sorour Edraki Najme Mohtavinejad Naser Amanlou Massoud 《International journal of peptide research and therapeutics》2020,26(4):2169-2177
International Journal of Peptide Research and Therapeutics - β-secretase 1 (BACE1) plays a pivotal role in the pathology of Alzheimer?s disease via accumulation beta amyloid in the... 相似文献
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Soltani Narges Nazarian-Firouzabadi Farhad Shafeinia Alireza Sadr Ayeh Sadat Shirali Masoud 《Molecular biology reports》2020,47(9):7009-7016
Molecular Biology Reports - Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus... 相似文献
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Leishmania (L.) tropica is a causative agent of human cutaneous and viscerotropic leishmaniasis. Immune response to L. tropica in humans and experimental animals are not well understood. We previously established that L. tropica infection induces partial protective immunity against subsequent challenge infection with Leishmania major in BALB/c mice. Aim of the present study was to study immunologic mechanisms of protective immunity induced by L. tropica infection, as a live parasite vaccine, in BALB/c mouse model. Mice were infected by L. tropica, and after establishment of the infection, they were challenged by L. major. Our findings shows that L. tropica infection resulted in protection against L. major challenge in BALB/c mice and this protective immunity is associated with: (1) a DTH response, (2) higher IFN-γ and lower IL-10 response at one week post-challenge, (3) lower percentage of CD4+ lymphocyte at one month post-challenge, and (4) the source of IFN-γ and IL-10 were mainly CD4− lymphocyte up to one month post-challenge suggesting that CD4− lymphocytes may be responsible for protection induced by L. tropica infection in the studied intervals. 相似文献