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31.
H.O.J. Collier Alison A. Francis Wendy J. McDonald-Gibson S.A. Saeed 《Prostaglandins & other lipid mediators》1976,11(2):219-225
Sulphasalazine (SZ) inhibits prostaglandin (PG) biosynthesis with a potency comparable to that of aceylsalicylate. The metabolites of SZ, sulphapyridine and 5-aminosalicylic acid, were of considerably lower potency as inhibitors of PG biosynthesis in the synthetase preparations used. The inhibition of prostaglandin production by SZ could at least partly account for the clinical utility of sulphasalazine in ulcerative colitis. Sulphapyridine may help to maintain inhibitory concentrations of SZ by restraining bacterial breakdown of the active drug. 相似文献
32.
Further evidence is given that dependence arises from the agonist action of opiates. From this and our previous propositions assigning a fundamental role to neuronal cyclic AMP in (i) the agonist action of opiates and (ii) the expression of the abstinence syndrome, it follows that opiate dependence is a state of heightened potential activity of a neuronal cyclic AMP mechanism, initiated and maintained by the blockade of an adenylate cyclase. Various possible mechanisms are discussed by which this potential is heightened. New evidence is given that morphine and naloxone stimulate prostaglandin biosynthesis without mutual antagonism. Preliminary evidence also is given that (i) the formation of cyclic AMP is enhanced in brain homogenates from heroin-dependent rats, and (ii) an acidified ethylacetate extract of brains of morphine-dependent rats induces quasi-abstinence effects when injected into a lateral cerebral ventricle of naive rats. 相似文献
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34.
Arash Salmaninejad Saeed Farajzadeh Valilou Arezoo Gowhari Shabgah Saeed Aslani Malihe Alimardani Alireza Pasdar Amirhossein Sahebkar 《Journal of cellular physiology》2019,234(10):16824-16837
Over the course of past few years, cancer immunotherapy has been accompanied with promising results. However, preliminary investigations with respect to immunotherapy concentrated mostly on targeting the immune checkpoints, nowadays, emerge as the most efficient strategy to raise beneficial antitumor immune responses. Programmed cell death protein 1 (PD-1) plays an important role in subsiding immune responses and promoting self-tolerance through suppressing the activity of T cells and promoting differentiation of regulatory T cells. PD-1 is considered as an immune checkpoint and protects against autoimmune responses through both induction of apoptosis in antigen-specific T cells and inhibiting apoptosis in regulatory T cells. Several clinical trials exerting PD-1 monoclonal antibodies as well as other immune-checkpoint blockades have had prosperous outcomes and opened new horizons in tumor immunotherapy. Nonetheless, a bulk of patients have failed to respond to these newly emerging immune-based approach and the survival rate was not satisfying. Additional strategies, especially combination therapies, has been initiated and been further promising. Attempts to identify novel and well-suited predictive biomarkers are also sensed. In this review, the promotion of cancer immunotherapy targeting PD-1 immunoinhibitory pathway is discussed. 相似文献
35.
In vitro improvement of quail primordial germ cell expansion through activation of TGF‐beta signaling pathway
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J P Nagpal R K Wali R Singh S Farooqui S Majumdar A Mahmood 《Biochemical medicine》1985,34(2):207-213
The effect of isatin (indole-2,3-dione) on D-glucose uptake has been studied in rat intestine. Isatin at 6 mM concentration significantly inhibited both the sugar uptake and transmural (mucosal to serosal side) transport in the intestine. The suppression of glucose uptake by isatin was irreversible. Similar to the action of various SH-group-reacting agents, isatin inhibited the sugar uptake, presumably by binding to membrane sulfhydryl groups through a covalent linkage. Isatin-induced reduction in glucose uptake was unaffected by pH (between 5.5 and 8.4) and by DTT addition to incubation medium. Inhibition of sugar uptake by isatin and harmaline was additive in nature; this suggested that these compounds interact at different sites on the microvillus membrane surface. 相似文献
38.
Nazemian Maryam Hojati Vida Zavareh Saeed Madanchi Hamid Hashemi-Moghaddam Hamid 《International journal of peptide research and therapeutics》2020,26(1):259-269
International Journal of Peptide Research and Therapeutics - Chemotherapy using drug delivery systems can target tumor cells selectively and do not affect normal cells. In this paper, a specific... 相似文献
39.
Abarghooi Kahaki Fatemeh Monzavi Sakineh Bamehr Hadi Bandani Eshagh Payandeh Zahra Jahangiri Abolfazl Khalili Saeed 《International journal of peptide research and therapeutics》2020,26(4):2077-2087
International Journal of Peptide Research and Therapeutics - Membrane proteins play important functions, such as cellular communication and transferring materials in the cell. Many membrane... 相似文献
40.
Rahbar Mohammad Reza Zarei Mahboubeh Jahangiri Abolfazl Khalili Saeed Nezafat Navid Negahdaripour Manica Fattahian Yaser Ghasemi Younes 《International journal of peptide research and therapeutics》2020,26(3):1269-1282
International Journal of Peptide Research and Therapeutics - Acinetobacter baumannii is an important pathogen responsible for nosocomial infections worldwide. Trimeric autotransporters, the... 相似文献