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Azam Sadat Hosseini Alhashemi Abdolreza R. Karbassi Bahram Hassanzadeh Kiabi Seyed Masoud Monavari Seyed Mohammad Bagher Nabavi Mohammad Sadegh Sekhavatjou 《Biological trace element research》2011,142(3):500-516
Present study investigates relationships between total and bioaccessibility of trace elements (Cd, Co, Cr, Cu, Mn, NI, Pb,
V, and Zn) concentrations in sediment and their bioaccumulation in species in Shadegan wetland in southwest of Iran. Bioavailability
factor (BAF) and translocation factor (TF) were calculated in plants and trophic transfer factor (TTF) was determined in bird
species. For this purpose, sampling of sediments, aquatic plants including Phragmites australis, Typha australis, Scripus maritimus and two bird species encircling Porphyrio porphyrio and globally threatened Marmaronetta angustirostris were carried out during winter 2009. Result of chemical analysis show that bioaccessibility concentrations of Mn (8.31 mg/kg),
V (1.33 mg/kg), and Pb (1.03 mg/kg) are higher than other metals. The uptake trend of trace elements in plant decreases as
root > stem > leaf. Accumulation levels of trace elements in different tissues of P. porphyrio and M. angustirostris are almost identical and considerable. Accumulation and toxicity of Cd in birds is more than plants. In addition, BAF of
V, Pb, and Cr indicates high accumulation by plants and great pollution rate in the area of study. In S. maritimus TF for Mn, Cu, Pb, and V are high whereas in T. australis, Cu and Pb posses the highest TF. Also Cr, Co, Mn, Ni, and Zn have higher TF from stem to leaf than root to stem in P. australis. Finally, TTFs were compared in various bird species. 相似文献
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Ambroziak U Pachucki J Bednarczuk T Pogorzelski R Toutounchi S Bogdańska M Koperski L Bar-Andziak E 《Endokrynologia Polska》2011,62(5):466-470
Bacterial thyroiditis is a rare disease, and one of which the clinical symptoms and signs are frequently misleading. On the other hand, prompt diagnosis is crucial for successful treatment. We report the case of an 82 year-old man with diabetes mellitus type 2 and a history of steroid treatment who presented with severe odynophagia and dysphagia associated with fever, chills, sore throat and right ear pain. Based on the clinical picture, radiological studies, thyroid cytology, blood and thyroid aspirate culture, suppurative thyroiditis caused by Salmonella enteritidis was diagnosed. The patient was successfully treated with antibiotics and surgical drainage. 相似文献
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Sharif Moradi Parisa Torabi Saeed Mohebbi Sara Amjadian Piter Bosma Farnoush Faridbod Vahid Khoddami Morteza Hosseini Sadegh Babashah Maryam Ghotbaddini Arezoo Rasti Faezeh Shekari Hamid Sadeghi-Abandansari Jafar Kiani Mehdi Shamsara Mohammad Kazemi-Ashtiani Samira Gholami 《BioEssays : news and reviews in molecular, cellular and developmental biology》2020,42(6):2000042
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ABSTRACT: BACKGROUND: Alpha 1- antitrypsin (alpha1AT) belongs to the superfamily of serpins and inhibits different proteases. alpha1AT protects the lung from cellular inflammatory enzymes. In the absence of alpha1AT, the degradation of lung tissue results to pulmonary complications. The pulmonary route is a potent noninvasive route for systemic and local delivery. The aerosolized alpha1AT not only affects locally its main site of action but also avoids remaining in circulation for a long period of time in peripheral blood. Poly (D, L lactide-co glycolide) (PLGA) is a biodegradable and biocompatible polymer approved for sustained controlled release of peptides and proteins. The aim of this work was to prepare a wide range of particle size as a carrier of protein-loaded nanoparticles to deposit in different parts of the respiratory system especially in the deep lung. Various lactide to glycolide ratio of the copolymer was used to obtain different release profile of the drug which covers extended and rapid drug release in one formulation. RESULTS: Nonaqueous and double emulsion techniques were applied for the synthesis of nanoparticles. Nanoparticles were characterized in terms of surface morphology, size distribution, powder X-ray diffraction (XRD), encapsulation efficiency, in vitro drug release, FTIR spectroscopy and differential scanning calorimetry (DSC). To evaluate the nanoparticles cytotoxicity, cell cytotoxicity test was carried out on the Cor L105 human epithelial lung cancer cell line. Nanoparticles were spherical with an average size in the range of 100 nm to 1mu. The encapsulation efficiency was found to be higher when the double emulsion technique was applied. XRD and DSC results indicated that alpha1AT encapsulated in the nanoparticles existed in an amorphous or disordered-crystalline status in the polymer matrix. The lactic acid to glycolic acid ratio affects the release profile of alpha1AT. Hence, PLGA with a 50:50 ratios exhibited the ability to release %60 of the drug within 8, but the polymer with a ratio of 75:25 had a continuous and longer release profile. Cytotoxicity studies showed that nanoparticles do not affect cell growth and were not toxic to cells. CONCLUSION: In summary, alpha1AT-loaded nanoparticles may be considered as a novel formulation for efficient treatment of many pulmonary diseases. 相似文献
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An evolutionary Wolff's law for trabecular architecture. 总被引:3,自引:0,他引:3
A continuum model is proposed to describe the temporal evolution of both the density changes and the reorientation of the trabecular architecture given the applied stress state in the bone and certain material parameters of the bone. The data upon which the proposed model is to be based consist of experimentally determined remodeling rate coefficients and quantitative stereological and anisotropic elastic constant measurements of cancellous bone. The model shows that the system of differential equations governing the temporal changes in architecture is necessarily nonlinear. This nonlinearity is fundamental in that it stems from the fact that, during remodeling, the relationship between stress and strain is changing as the stress and strain variables themselves are changing. In order to preserve the remodeling property of the model, terms that are of the order strain times the changes in density and/or microstructural properties must be retained. If these terms were dropped, there would be no feedback mechanism for architectural adaptation and no adaptation of the trabecular architecture. There is, therefore, no linearized version of the model of the temporal evolution of trabecular architecture. An application of the model is illustrated by an example problem in which the temporal evolution of homogeneous trabecular architecture is predicted. A limitation of the proposed continuum model is the length scale below which it cannot be applied. The model cannot be applied in regions of cancellous bone where the trabecular bone architecture is relatively inhomogeneous or at a bone-implant interface. 相似文献
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Reza Rashiditabar Najmeh Nozhat Mohammad Sadegh Zare 《Plasmonics (Norwell, Mass.)》2018,13(6):1853-1859
In this paper, a tunable plasmonic absorber based on TiN-nanosphere/liquid crystal (LC) nanocomposite in visible and near-infrared regions is proposed. TiN-nanosphere/LC nanocomposite is a combination of titanium nitride (TiN) nanospheres dispersed in a host of LC and plays the main role in post fabrication tunability. The proposed absorber has three more than 90% absorption peaks and the absorption tunability of about 76 nm. It is shown that TiN-nanospheres are able to support localized surface plasmon resonance (LSPR). The Maxwell-Garnett theory is utilized to approximate the permittivity of the composite structure. Also, the effect of geometric parameters on the absorption is studied. Moreover, a single sheet of graphene is utilized to compensate the decrement of the absorption caused by the geometric parameters. 相似文献
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Moheb Ali Pourgholam Hossein Khara Reza Safari Mohammad Ali Yazdani Sadati Mohammad Sadegh Aramli 《Probiotics and antimicrobial proteins》2016,8(1):1-7
We investigated the effects of Lactobacillus plantarum used as a dietary supplement on the growth performance and innate immune response in juvenile Siberian sturgeon Acipenser baerii. Juvenile fish (14.6 ± 2.3 g) were fed three experimental diets prepared by supplementing a basal diet with L. plantarum at different concentrations [1 × 107, 1 × 108 and 1 × 109 colony-forming units (cfu) g?1] and a control (non-supplemented basal) diet for 8 weeks. Growth performance indices were increased in fish fed the 1 × 108 cfu g?1 L. plantarum diet compared to the other groups. There was an increased innate immune response in fish fed the experimental diets. The highest levels of lysozyme activity, total immunoglobulin (IgM) and complement component 3 (C3) were observed in fish fed the diet containing L. plantarum at a concentration of 1 × 108 cfu g?1, but there was no significant difference in the level of complement component 4 (C4) in fish fed the experimental diets or the control diet. The present study underlying some positive effects (growth performance and immune indices) of dietary administration of L. plantarum at a concentration of 1 × 108 cfu g?1 in the Siberian sturgeon. 相似文献
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Jalil Jaafari Kazem Naddafi Masud Yunesian Ramin Nabizadeh Mohammad Sadegh Hassanvand Mohammad Ghanbari Ghozikali 《人类与生态风险评估》2018,24(2):482-493
The aim of this study is to survey the PM10, PM2.5, and PM1 concentrations in rural and urban areas in Tehran province during cold, warm and dust storm days from December 22, 2016 to June 5, 2017 using Grimm Model aerosol spectrometer. During the study period, daily PM10, PM2.5, and PM1 concentrations ranged from 27.2 to 244.96, 8.4 to 77.9, and 6.5 to 56.8 μg/m3 in urban sites, and 22.8 to 286.4, 6 to 41.1, and 2.1 to 20.2 μg/m3 in rural parts, respectively. Particularly, both daily WHO limits for outdoor PM10 (50.0 μg/m3) and PM2.5 (25.0 μg/m3) exceeded in 95% and 83% of the outdoor measurements in winter and 82% and 58% in total sampled days in urban site, respectively. The 24-h average PM10 and PM2.5 concentrations also exceeded by 59% and 18% in winter and by 36% and 14% of all sampling days in rural site, respectively. During the dust storm, the 24-h average PM10, PM2.5, and PM1 concentrations were, respectively 4.7, 2, and 1.96 times higher than those in urban site and 2, 1.7, and 1.3 times more than those in rural site in all sampled days. 相似文献