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311.
Fular Ashutosh Sharma Anil Kumar Upadhaya Deepak Nandi Abhijit Nagar Gaurav Bisht Nisha Shakya Mukesh Kumar Sachin Kumar Satyanshu Kumar Rajesh Ghosh Srikant 《Experimental & applied acarology》2021,85(2-4):355-377
Experimental and Applied Acarology - The resistance status against deltamethrin, cypermethrin, coumaphos and ivermectin was assessed of Rhipicephalus microplus from five districts of Uttarakhand,... 相似文献
312.
Shivani Sharma Pooja Chaudhary Rajat Sandhir Abhishek Bharadwaj Rajinder K. Gupta Rahul Khatri Amir Chand Bajaj T. P. Baburaj Sachin Kumar M. S. Pal Prasanna K. Reddy Bhuvnesh Kumar 《Cell stress & chaperones》2021,26(2):323
The present study aimed to investigate the differential response of oxidative (soleus) and glycolytic (gastrocnemius) muscles to heat-induced endoplasmic reticulum (ER) stress. It was hypothesized that due to compositional and functional differences, both muscles respond differently to acute heat stress. To address this, male Sprague Dawley rats (12/group) were subjected to thermoneutral (25 °C) or heat stress (42 °C) conditions for 1 h. Soleus and gastrocnemius muscles were removed for analysis post-exposure. A significant increase in body temperature and free radical generation was observed in both the muscles following heat exposure. This further caused a significant increase in protein carbonyl content, AOPP, and lipid peroxidation in heat-stressed muscles. These changes were more pronounced in heat-stressed soleus compared to the gastrocnemius muscle. Accumulation of unfolded, denatured proteins results in ER stress, causing activation of unfolded protein response (UPR) pathway. The expressions of UPR transducers were significantly higher in soleus as compared to the gastrocnemius muscle. A significant elevation in resting intracellular calcium ion was also observed in heat-stressed soleus muscle. Overloading of cells with misfolded proteins in soleus muscle activated ER-induced apoptosis as indicated by significant upregulation of C/EBP homologous protein and Caspase12. The study provides a detailed mechanistic representation of the differential response of muscles toward UPR under heat stress. Data suggests that soleus majorly being an oxidative muscle is more prone to heat stress-induced insult indicated by enhanced apoptosis. This study may aid in devising mitigation strategies to improve muscle performance under heat stress.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12192-020-01178-x. 相似文献
313.
Ashwathi Rajeevan Riya Keshri Sukriti Kapoor Sachin Kotak 《Molecular biology of the cell》2020,31(22):2437
NuMA is an abundant long coiled-coil protein that plays a prominent role in spindle organization during mitosis. In interphase, NuMA is localized to the nucleus and hypothesized to control gene expression and chromatin organization. However, because of the prominent mitotic phenotype upon NuMA loss, its precise function in the interphase nucleus remains elusive. Here, we report that NuMA is associated with chromatin in interphase and prophase but released upon nuclear envelope breakdown (NEBD) by the action of Cdk1. We uncover that NuMA directly interacts with DNA via evolutionarily conserved sequences in its C-terminus. Notably, the expression of the DNA-binding–deficient mutant of NuMA affects chromatin decondensation at the mitotic exit, and nuclear shape in interphase. We show that the nuclear shape defects observed upon mutant NuMA expression are due to its potential to polymerize into higher-order fibrillar structures. Overall, this work establishes the spindle-independent function of NuMA in choreographing proper chromatin decompaction and nuclear shape by directly associating with the DNA. 相似文献
314.
Background
The Poly(ADP-ribose)polymerase (PARP) superfamily was originally identified as enzymes that catalyze the attachment of ADP-ribose subunits to target proteins using NAD+ as a substrate. The family is characterized by the catalytic site, termed the PARP signature. While these proteins can be found in a range of eukaryotes, they have been best studied in mammals. In these organisms, PARPs have key functions in DNA repair, genome integrity and epigenetic regulation. More recently it has been found that proteins within the PARP superfamily have altered catalytic sites, and have mono(ADP-ribose) transferase (mART) activity or are enzymatically inactive. These findings suggest that the PARP signature has a broader range of functions that initially predicted. In this study, we investigate the evolutionary history of PARP genes across the eukaryotes. 相似文献315.
The present paper reports on palynology and pollination ecology of eight taxa of Amorphophallus from North Western Ghats (NWGS) and Konkan region of India. Out of ten known pollen exine ornamentations of the genus, six are represented – psilate, striate, fossulate, verrucate, scabrate and the new type ‘pseudofossulate’ of Amorphophallus commutatus var. wayanadensis. These diverse pollen exine ornamentations can be utilized as an important taxonomic tool to distinguish taxa and also to resolve taxonomic problems (A. commutatus complex). The pollen of all eight taxa had retained their sculptured surface (exine ornamenatation type) after acetolysis. This clearly demonstrates that these taxa do not show susceptibility to the conventional acetolysis technique as reported earlier. The present study also highlights the importance of pollen surface morphology concerning phytogeography of the genus. 相似文献
316.
Gulati S Gupta N Singh NP Batra S Garg S Beniwal P Kumar S 《Parasitology international》2007,56(3):251-254
Lymphatic filariasis is endemic in India. Out of 128 million infected individuals worldwide, India accounts for 48 million cases [Manson's Tropical Diseases, 21st Ed. p 1488]. Filariasis can have protean manifestations, but Tropical pulmonary eosinophilia and chyluria are unusual manifestations reported mainly from South Asian countries [Manson's Tropical Diseases, 21st Ed. p 1494]. Chyluria occurs only in 2% of filarial afflicted patients in the filarial belt [Diamond E, Schapira HE. Chyluria--a review of literature. Urology 1985;26(5): 427-31]. Lymphatic filariasis presenting as chyluria may be equally rare. Predominant chyluria with no overt lymphatic filariasis remains an enigma. 相似文献
317.
Background
The presence of β-lactamases in Y. enterocolitica has been reported to vary with serovars, biovars and geographical origin of the isolates. An understanding of the β-lactamases in other related species is important for an overall perception of antibiotic resistance in yersiniae. The objective of this work was to study the characteristics of β-lactamases and their genes in strains of Y. intermedia and Y. frederiksenii, isolated from clinical and non-clinical sources in India. 相似文献318.
319.
Daljeet Kaur Saggu Sandeep G. Nair Abhijeet Shelke Sachin Yalagudri Calambur Narasimhan 《Indian pacing and electrophysiology journal》2015,15(6):300-302
A 55 year old male presented with recurrent implantable cardioverter defibrillator (ICD) shocks due to polymorphic ventricular tachycardia (PMVT). He had undergone prior catheter ablation for VT three years ago. During the prior attempt he underwent voltage guided substrate ablation. With programmed ventricular extrastimulation (PVES), PMVT was repeatedly induced requiring DC shock. Intravenous procainamide was administered and PVES was repeated which induced sustained monomorphic ventricular tachycardia (MMVT). This VT had pseudo delta waves with maximum deflection index of 0.68, suggestive of epicardial origin. Activation mapping was performed epicardially. Presystolic potentials were recorded in mid anterolateral wall of left ventricular epicardial region. Radiofrequency (RF) ablation at this site terminated the VT. Post ablation there was no inducible tachycardia and patient is free of arrhythmias during 2 years of follow-up. 相似文献
320.
Neha Gupta Mercilena Benjamin Anjana Kar Sachin Dev Munjal Aditya N. Sarangi Ashwin Dalal Rakesh Aggarwal 《PloS one》2015,10(12)