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111.
Albert Eduardo Silva Martins Norma Lucena-Silva Renan Gomes Garcia Stefan Welkovic Aureliana Barboza Maria Luiza Bezerra Menezes Magda Maruza Terezinha Tenório Ricardo AA Ximenes 《Memórias do Instituto Oswaldo Cruz》2014,109(6):738-747
Human immunodeficiency virus (HIV)-positive patients have a greater prevalence of
coinfection with human papillomavirus (HPV) is of high oncogenic risk. Indeed, the
presence of the virus favours intraepithelial squamous cell lesion progression and
may induce cancer. The aim of this study was to evaluate the prevalence of HPV
infection, distribution of HPV types and risk factors among HIV-positive patients.
Cervical samples from 450 HIV-positive patients were analysed with regard to oncotic
cytology, colposcopy and HPV presence and type by means of polymerase chain reaction
and sequencing. The results were analysed by comparing demographic data and data
relating to HPV and HIV infection. The prevalence of HPV was 47.5%. Among the
HPV-positive samples, 59% included viral types of high oncogenic risk. Multivariate
analysis showed an association between HPV infection and the presence of cytological
alterations (p = 0.003), age greater than or equal to 35 years (p = 0.002), number of
partners greater than three (p = 0.002), CD4+ lymphocyte count <
200/mm3 (p = 0.041) and alcohol abuse (p = 0.004). Although high-risk
HPV was present in the majority of the lesions studied, the low frequency of HPV 16
(3.3%), low occurrence of cervical lesions and preserved immunological state in most
of the HIV-positive patients were factors that may explain the low occurrence of
precancerous cervical lesions in this population. 相似文献
112.
Archives of Microbiology - 相似文献
113.
Expression of the 3C protease gene of poliovirus type 1 (Mahoney) in E. coli cells using various vectors was studied. The 3C gene was shown to be expressed effectively upon its cloning in HindII/HindII (bases 5240 to 6770) and in HindII/HindIII (bases 5240 to 6056) fragments of poliovirus cDNA in pTTQ8 vector containing tac-promoter and lacI-repressor gene. Products of processing at the N-terminal 3C protease Gln-Gly site and polypeptides formed upon translation from an alternative methionine, which was coded by bases 5516-5518 of poliovirus cDNA, were found among virus-specific proteins. Processing at the C-terminal 3C protease Gln-Gly site was not observed. 相似文献
114.
T.V. Pochechueva O.E. Galanina N.A. Ushakova M.E. Preobrazhenskaya M.A. Sablina N.E. Nifantiev Yu.V. Tsvetkov Ya.V. Vozney A. Imberty N.V. Bovin 《Glycoconjugate journal》2003,20(2):91-97
The blocking potency of P- and L-selectin was studied for certain small molecule mannosides and their polyacrylamide (PAA,
30 kDa) conjugates in comparison to SiaLex and fucoidan. Two experimental systems were used: (1) solid phase static assay based on recombinant selectins, and (2) P-selectin
dependent rat peritoneal inflammation. βMan-SC6H4NO2-p was four times more potent P-selectin inhibitor as compared to SiaLex. Docking of this molecule onto the P-selectin carbohydrate-binding site demonstrated that a nitro group enabled an electrostatic
interaction with residue Lys 84, while the phenyl ring and the CH2 at C-6 contacted the CH2 groups of the same Lys residue. In vivo, βMan-SC6H4NO2-p blocked experimental inflammation better than SiaLex, but significantly lower than fucoidan. In vitro Man-polyacrylic acid conjugates appeared to be very potent inhibitors comparable to fucoidan, uncharged Man-PAA proved rather
active, comparable to SiaLex-PAA both in vitro, and in vivo, whereas mannan did not display any P-selectin blocking effect. Published in 2004.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
115.
O V Sablina 《Genetika》1978,14(11):1919-1927
It is shown that herpes simplex virus can induce the chromosome aberrations both in cells supporting the productive infection and in non-permissive cells. In virus-infected human embryo fibroblast culture the activity of cell (lysosomal) and virus-coded DNAses is elevated. Suppression of the activity of any of the enzymes leads to decreasing the number of aberrant cells. Suppression of the activity of both DNases at the same time decreases the number of aberrant cells to a control level. In M15 cells which do not support the productive infection, the activity of only lysosomal DNase is elevated. Suppression of its activity leads to the decrease of the frequency of cells with chromosome breaks to a control level. Thus, both cells and virus-coded lytic enzymes can participate in the production of chromosome breaks in virus-infected cells. Possibly, the relative role of these enzymes may be rather different in different virus-cell systems. 相似文献
116.
117.