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排序方式: 共有219条查询结果,搜索用时 78 毫秒
211.
Kia Joo Puan John Seng Hooi Low Terence Wee Kiat Tan Joseph Tien Seng Wee Eng Huat Tan Kam Weng Fong Eu Tiong Chua Chenggang Jin José-Luis Giner Craig T. Morita Christopher Hood Keng Goh Kam M. Hui 《Cancer immunology, immunotherapy : CII》2009,58(7):1095-1107
Introduction Human Vγ2Vδ2 T cells play important role in immunity to infection and cancer by monitoring self and foreign isoprenoid metabolites
with their γδ T cell antigen receptors. Like CD4 and CD8 αβ T cells, adult peripheral Vγ2Vδ2 T cells represent a pool of heterogeneous
cells with distinct functional capabilities.
Purpose The aim of this study was to characterize the phenotypes and functions of various Vγ2Vδ2 T cell subsets in patients with nasopharyngeal
carcinoma (NPC). We sought to develop a better understanding of the role of these cells during the course of disease and to
facilitate the development of immunotherapeutic strategies against NPC.
Results Although similar total percentages of peripheral blood Vγ2Vδ2 T cells were found in both NPC patients and normal donors, Vγ2Vδ2
T cells from NPC patients showed decreased cytotoxicity against tumor cells whereas Vγ2Vδ2 T cells from normal donors showed
potent cytotoxicity. To investigate further, we compared the phenotypic characteristics of Vγ2Vδ2 T cells from 96 patients
with NPC and 54 healthy controls. The fraction of late effector memory Vγ2Vδ2 T cells (TEM RA) was significantly increased in NPC patients with corresponding decreases in the fraction of early memory Vγ2Vδ2 T cells
(TCM) compared with those in healthy controls. Moreover, TEM RA and TCM Vγ2Vδ2 cells from NPC patients produced significantly less IFN-γ and TNF-α, potentially contributing to their impaired cytotoxicity.
Radiotherapy or concurrent chemo-radiotherapy further increased the TEM RA Vγ2Vδ2 T cell population but did not correct the impaired production of IFN-γ and TNF-α observed for TEM RA Vγ2Vδ2 T cells.
Conclusion We have identified distinct alterations in the Vγ2Vδ2 T cell subsets of patients with NPC. Moreover, the overall cellular
effector function of γδ T cells is compromised in these patients. Our data suggest that the contribution of Vγ2Vδ2 T cells
to control NPC may depend on the activation state and differentiation of these cells.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
212.
SC Voss Z Nikolovski PC Bourdon M Alsayrafi YO Schumacher 《Biology of sport / Institute of Sport》2016,33(1):23-28
Leptin and adiponectin play an essential role in energy metabolism. Leptin has also been proposed as a marker for monitoring training load. So far, no studies have investigated the variability of these hormones in athletes and how they are regulated during cumulative exercise. This study monitored leptin and adiponectin in 15 endurance athletes twice daily in the days before, during and after a 9-day simulated cycling stage race. Adiponectin significantly increased during the race (p = 0.001) and recovery periods (p = 0.002) when compared to the baseline, while leptin decreased significantly during the race (p < 0.0001) and returned to baseline levels during the recovery period. Intra-individual variability was substantially lower than inter-individual variability for both hormones (leptin 34.1 vs. 53.5%, adiponectin 19% vs. 37.2%). With regards to exercise, this study demonstrated that with sufficient, sustained energy expenditure, leptin concentrations can decrease within the first 24 hours. Under the investigated conditions there also appears to be an optimal leptin concentration which ensures stable energy homeostasis, as there was no significant decrease over the subsequent race days. In healthy endurance athletes the recovery of leptin takes 48-72 hours and may even show a supercompensation-like effect. For adiponectin, significant increases were observed within 5 days of commencing racing, with these elevated values failing to return to baseline levels after 3 days of recovery. Additionally, when using leptin and adiponectin to monitor training loads, establishing individual threshold values improves their sensitivity. 相似文献
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Tamako Nishimura Takuya Oyama Hooi Ting Hu Toshifumi Fujioka Kyoko Hanawa-Suetsugu Kazutaka Ikeda Sohei Yamada Hiroki Kawana Daisuke Saigusa Hiroki Ikeda Rie Kurata Kayoko Oono-Yakura Manabu Kitamata Kazuki Kida Tomoya Hikita Kiyohito Mizutani Kazuma Yasuhara Yuko Mimori-Kiyosue Shiro Suetsugu 《Developmental cell》2021,56(6):842-859.e8
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217.
Michelle Y. S. Hooi Mark J. Raftery Roger J. W. Truscott 《Protein science : a publication of the Protein Society》2013,22(1):93-100
Racemization is one of the most abundant modifications in long‐lived proteins. It has been proposed that the accumulation of such modifications over time could lead to changes in tissues and ultimately human age‐related diseases. Serine is one of the main amino acids involved in racemization; however, the site of D‐Ser in any aged protein has yet to be reported. In this study, racemization of two residues, Ser 59 and Ser 62, has been demonstrated in an unstructured region of the small heat shock protein, αA‐crystallin. αA‐crystallin is also the most abundant structural protein in the human lens. D‐Ser increased linearly with age in normal lenses, until it accounted for approximately 35% of the Ser at both sites by the age of 75 years. In agreement with a possible role in human age‐related disease, levels were significantly higher in cataract lenses. It is likely that such prevalent age‐related changes contribute to the denaturation of α‐crystallin, and therefore its ability to act as a chaperone. Racemization of amino acids, such as serine, in flexible regions of long‐lived proteins, could be associated with the development of human age‐related conditions such as cataract. 相似文献
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