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911.
The ontogeny, adrenal-feedback regulation and regional distribution of the mineralocorticoid receptor (MR) mRNA were examined in the rat brain and kidney. In the kidney, MR mRNA levels in the adult were only 25-30% of the neonatal concentration. Adrenalectomy caused a 35% increase in total brain MR mRNA and a 94% increase in kidney MR mRNA levels. Examination of the regional distribution of the MR mRNA within the brain revealed that the hippocampus had the highest levels, and the mRNA abundance increased after adrenalectomy. The administration of dexamethasone to intact animals resulted in a significant reduction of MR mRNA in the kidney of neonatal rats but not in the brain. These data indicate that there are developmental changes in MR gene expression in kidney and that adrenal steroids can modulate MR gene expression in both the brain and kidney. 相似文献
912.
R. C. Meyer D. Milbourne C. A. Hackett J. E. Bradshaw J. W. McNichol R. Waugh 《Molecular genetics and genomics : MGG》1998,259(2):150-160
We have constructed a partial linkage map in tetraploid potato which integrates simplex, duplex and double-simplex AFLP markers. The map consists of 231 maternal and 106 paternal markers with total map lengths of 990.9?cM and 484.6?cM. The longer of the two cumulative map lengths represents approximately 25% coverage of the genome. In tetraploids, much of the polymorphism between parental clones is masked by `dosage' which significantly reduces the number of individual markers that can be scored in a population. Consequently, the major advantage of using AFLPs – their high multiplex ratio – is reduced to the point where the use of alternative multi-allelic marker types would be significantly more efficient. The segregation data and map information have been used in a QTL analysis of late blight resistance, and a multi-allelic locus at the proximal end of chromosome VIII has been identified which contributes significantly to the expression of resistance. No late blight resistance genes or QTLs have previously been mapped to this location. 相似文献
913.
The reproductive organs of logn-term captive females and of wild females of the western swamp tortoise, Pseudemydura umbrina , which were taken temporarily into captivity, were studied over several years by ultra-sound scanning. Pseudemydura umbrina , a critically-endangered species, is active during winter and spring when the ephemeral swamps it inhabits contain water and aestivates during summer and autumn (November to May/June) when the swamps are dry. The vitellogenic growth of ovarian follicles commences during aestivation in summer and continues during autumn and winter. The timing of the vitellogenic cycle is remarkably similar to that of many other Australian chelids and that of many other chelonians of temperate and subtropical regions, but the patterns of energy harvest, storage and allocation to ovarian follicles is different. Ovulation occurs between late September and early November and is preceded by a feeding bout and a sharp increase in female body mass. One clutch of 3–5 eggs (exceptionally of one or two) is laid in November/December. Sub-adult females show cycles of follicular growth, followed by atresia, for several years before ovulating and laying eggs. Females taken into captivity may miss the following vitelogenic cycle, but captivity does not generally affect vitellogenic cycles. Ovulation and egg production of captive animals is easily suppressed, however, under stress or sub-optimal food intake in spring. The sensitivity of ovulation to sub-optimal conditions and the subsequent reabsorption of the yolk material may enhance survival of the reproducing individual during long dry periods in an unpredictable environment. 相似文献
914.
I. C. Field M. G. Meekan C. W. Speed W. White C. J. A. Bradshaw 《Coral reefs (Online)》2011,30(1):61-71
Grey reef sharks (Carcharhinus amblyrhynchos) are apex predators found on many Indo-Pacific coral reefs, but little is known about their movement patterns and habitat
requirements. We used acoustic telemetry to determine movements and habitat use of these sharks at the isolated Rowley Shoals
atolls, 250 km off the coast of north-western Australia. We equipped 12 male and 14 female sharks ranging from 0.79 to 1.69 m
in total length with transmitters that were detected by an array of 11 strategically placed receivers on two atoll reefs.
Over 26,000 detections were recorded over the 325 days of receiver deployment. No sharks were observed to move between reefs.
Receivers on the outer slopes of reefs provided nearly all (99%) of the detections. We found no differences in general attendance
parameters due to size, sex or reef, except for maximum period of detection where larger sharks were detected over a longer
period than smaller sharks. Male and female sharks were often detected at separate receivers at the outer slope habitat of
one reef, suggesting sexual segregation, but this pattern did not occur at the second reef where males and females were detected
at similar frequencies. We identified two patterns of daily behaviour: (1) sharks were present at the reef both day and night
or (2) sharks spent more time in attendance during day than at night. Fast Fourier transforms identified 24-h cycles of attendance
at the reef and a secondary peak of attendance at 12 h for most sharks, although no individuals shared the same attendance
patterns. Our study provides baseline data that can be used to optimise the minimum area and habitat requirements for conservation
of these apex predators. 相似文献
915.
916.
917.
Adam Drewnowski James Buszkiewicz Anju Aggarwal Chelsea Rose Shilpi Gupta Annie Bradshaw 《Obesity (Silver Spring, Md.)》2020,28(1):22-30
The built environment (BE) has been viewed as an important determinant of health. Numerous studies have linked BE exposure, captured using a variety of methods, to diet quality and to area prevalence of obesity, diabetes, and cardiovascular disease. First‐generation studies defined the neighborhood BE as the area around the home. Second‐generation studies turned from home‐centric to person‐centric BE measures, capturing an individual’s movements in space and time. Those studies made effective uses of global positioning system tracking devices and mobile phones, sometimes coupled with accelerometers and remote sensors. Activity space metrics explored travel paths, modes, and destinations to assess BE exposure that was both person and context specific. However, as measures of the contextual exposome have become ever more fine‐grained and increasingly complex, connections to long‐term chronic diseases with complex etiologies, such as obesity, are in danger of being lost. Furthermore, few studies on obesity and the BE have included intermediate energy balance behaviors, such as diet and physical activity, or explored the potential roles of social interactions or psychosocial pathways. Emerging survey‐based applications that identify habitual destinations and associated travel patterns may become the third generation of tools to capture health‐relevant BE exposures in the long term. 相似文献
918.
J.C. Sleeman M.G. Meekan C.R. Steinberg C.J.A. Bradshaw 《Journal of experimental marine biology and ecology》2010,382(2):77-81
Seasonal observations of whale shark abundance recorded by ecotourist operators at Ningaloo Reef, Western Australia from 1999 to 2004 were compared with weekly regional and global oceanographic and atmospheric variables, including average sea surface temperatures, along-shelf wind shear, sea level and the Southern Oscillation Index (SOI). Estimates of these physical variables were derived from either ground-based data or from remote sensing instruments. A generalised linear mixed-effects modelling (GLMM) approach with random sampling and model simulation was used to determine the relationships between the number of whale sharks and all model variants of the environmental parameters, using information-theoretic weights of evidence to rank models. SOI and wind shear had the most support for explaining the deviance in weekly whale shark abundance at Ningaloo Reef during a season. The SOI and wind shear variables positively influenced whale shark abundance such that more sharks were sighted when the Southern Oscillation was stronger and along-shelf winds were increasingly prevalent. This may reflect changes in the strength of oceanographic processes such as the Leeuwin Current (in response to the Southern Oscillation) and wind/current driven upwelling which may affect the abundance of whale sharks transported to the region and/or the availability of their prey by driving productivity changes. 相似文献
919.
The continental scale migrations of Fagus sylvatica L. and Picea abies (L.) Karst. are under a broad climatic control, but disturbance and local factors influence the immigration of these species into individual forest stands. Palaeoecological analysis of a small forest hollow in the boreo-nemoral zone of southern Sweden has shown that a forest stand with largely unbroken forest continuity resisted immigration of Fagus for almost 1000 years. Two fires about 950 and 330 years ago were the disturbing factors that facilitated eventual Fagus immigration. Picea immigrated and achieved co-dominance in a single generation, without resistance from the existing forest. Thus migrational lag is demonstrable for Fagus but not Picea . The immigration of these two dominating species coupled with a severe reduction in tree species diversity has resulted in a total change in forest competition during the last few centuries despite the maintenance of a structural forest continuity. Some of these changes are attributable to changes in the grazing regime, but the forest stand is as close to «natural>> conditions as can be found in S. Sweden. 相似文献
920.
Role of glandular kallikreins as growth factor processing enzymes: structural and evolutionary considerations 总被引:2,自引:0,他引:2
Hormones and growth factors are generally released from larger precursors by limited proteolysis. The causative agents remain poorly defined with respect to location and properties. One subset of proteases, the glandular kallikreins, have been implicated in a few cases, in part because of their specific association with mature forms of some hormones. However, limited distribution and low copy number in some species cast doubt on this hypothesis, and they may well play other physiological functions that remain to be elucidated. 相似文献