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Tina L. Yuan Arnaud Amzallag Rachel Bagni Ming Yi Shervin Afghani William Burgan Nicole Fer Leslie A. Strathern Katie Powell Brian Smith Andrew M. Waters David Drubin Ty Thomson Rosy Liao Patricia Greninger Giovanna T. Stein Ellen Murchie Eliane Cortez Frank McCormick 《Cell reports》2018,22(7):1889-1902
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Identification of the novel recessive gene pi55(t) conferring resistance to Magnaporthe oryzae 总被引:2,自引:0,他引:2
XiuYing He XinQiong Liu Li Wang Ling Wang Fei Lin YongSheng Cheng ZhaoMing Chen YaoPing Liao QingHua Pan 《中国科学:生命科学英文版》2012,55(2):141-149
The elite rice cultivar Yuejingsimiao 2 (YJ2) is characterized by a high level of grain quality and yield, and resistance
against Magnaporthe oryzae. YJ2 showed 100% resistance to four fungal populations collected from Guangdong, Sichuan, Liaoning, and Heilongjiang Provinces,
which is a higher frequency than that shown by the well-known resistance (R) gene donor cultivars such as Sanhuangzhan 2 and 28zhan. Segregation analysis for resistance with F2 and F4 populations indicated the resistance of YJ2 was controlled by multiple genes that are dominant or recessive. The putative
R genes of YJ2 were roughly tagged by SSR markers, located on chromosomes 2, 6, 8, and 12, in a bulked-segregant analysis using
genome-wide selected SSR markers with F4 lines that segregated into 3 resistant (R):1 susceptible (S) or 1R:3S. The recessive R gene on chromosome 8 was further mapped to an interval ≈1.9 cM/152 kb in length by linkage analysis with genomic position-ready
markers in the mapping population derived from an F4 line that segregated into 1R:3S. Given that no major R gene was mapped to this interval, the novel R gene was designated as pi55(t). Out of 26 candidate genes predicted in the region based on the reference genomic sequence of the cultivar Nipponbare,
two genes that encode a leucine-rich repeat-containing protein and heavy-metal-associated domain-containing protein, respectively,
were suggested as the most likely candidates for pi55(t). 相似文献
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Zhe Liu Kun Cao Zebin Liao Yuanyuan Chen Xiao Lei Qun Wei Cong Liu Xuejun Sun Yanyong Yang Jianming Cai Fu Gao 《Journal of cellular and molecular medicine》2020,24(7):3917-3930
Radiation protection on male testis is an important task for ionizing radiation-related workers or people who receive radiotherapy for tumours near the testicle. In recent years, Toll-like receptors (TLRs), especially TLR4, have been widely studied as a radiation protection target. In this study, we detected that a low-toxicity TLR4 agonist monophosphoryl lipid A (MPLA) produced obvious radiation protection effects on mice testis. We found that MPLA effectively alleviated testis structure damage and cell apoptosis induced by ionizing radiation (IR). However, as the expression abundance differs a lot in distinct cells and tissues, MPLA seemed not to directly activate TLR4 singling pathway in mice testis. Here, we demonstrated a brand new mechanism for MPLA producing radiation protection effects on testis. We observed a significant activation of TLR4 pathway in macrophages after MPLA stimulation and identified significant changes in macrophage-derived exosomes protein expression. We proved that after MPLA treatment, macrophage-derived exosomes played an important role in testis radiation protection, and specially, G-CSF and MIP-2 in exosomes are the core molecules in this protection effect. 相似文献
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TL Liao AC Lin E Chen TW Huang YM Liu YH Chang JF Lai TL Lauderdale JT Wang SC Chang SF Tsai YT Chen 《Journal of bacteriology》2012,194(19):5454
We report the complete genome sequence of Klebsiella oxytoca E718, a New Delhi metallo-β-lactamase-1 (NDM-1)-producing strain isolated from a renal transplant patient. The genome contains a 6,097,032-bp chromosome and two multidrug resistance plasmids with sizes of 324,906 bp and 110,781 bp. 相似文献