ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy

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An analysis of intraoperative blood transfusion of cardiac surgery in one hospital from 2014 to 2016

To investigate the usage of blood componentsfor cardiac surgery inthe First Hospital of Lanzhou University, data from January 2014 to December 2016 were collected for analysis, including the number of cardiac surgeries and blood transfusions. There were 1 589 males and 1 076 females, aged from 1 to 73 years, with an average age of (53.97 ± 11.33) years, in this study. The results showed that the rate of blood-free surgery in the hospital increased year by year,while the proportion of blood-used operation to total operations decreased every year. The ratio of plasma and platelets used in cardiac surgery decreased, while the cryoprecipitate ratio used in cardiac surgery increased. This study indicates that the transfusion medical level in cardiac surgery is improved continuously, and that the infusion of blood components has become more secure, efficient and rational.     

Transient expression of a TaGRF4-TaGIF1 complex stimulates wheat regeneration and improves genome editing

Science China Life Sciences - Genome editing is an unprecedented technological breakthrough but low plant regeneration frequencies and genotype dependence hinder its implementation for crop...     

LINC01579 promotes cell proliferation by acting as a ceRNA of miR-139-5p to upregulate EIF4G2 expression in glioblastoma

Glioblastoma (GBM), a malignant and lethal tumor, remains a big threat to human health and life. Increasing explorations have confirmed that long noncoding RNAs are involved in the tumorigenesis and development of multiple cancers. Nevertheless, the regulatory mechanism of (long intergenic nonprotein coding RNA 1579 LINC01579) in GBM remains to be investigated. In this study, the expression of LINC01579 was upregulated in GBM cells and LINC01579 knockdown inhibited cell proliferation as well as promoted cell apoptosis. Additionally, LINC01579 acted as a sponge for miR-139-5p in GBM and eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) was found to be a downstream target of miR-139-5p. Furthermore, the positive correlation of LINC01579 and EIF4G2 as well as the converse correlation between miR-139-5p and LINC01579 (or EIF4G2) were revealed by the experiments. Based on rescue assays, EIF4G2 overexpression or miR-139-5p inhibitor partially recovered the function of LINC01579 knockdown on cell proliferation and apoptosis. In summary, the results of this study verified that LINC01579 modulated cell proliferation and cell apoptosis in GBM by competitively binding with miR-139-5p to regulate EIF4G2, which provided a new clue to figure out potential therapy for patients suffered from GBM.     

Calculation of an Adequate Intake (AI) Value and Safe Range of Selenium (Se) for Chinese Infants 0–3 Months Old Based on Se Concentration in the Milk of Lactating Chinese Women with Optimal Se Intake

Biological Trace Element Research - The required selenium intake for optimal health in Chinese residents was published in 2014. However, the adequate intake (AI) value for Chinese infants...