全文获取类型
收费全文 | 162篇 |
免费 | 8篇 |
出版年
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 6篇 |
2018年 | 3篇 |
2017年 | 8篇 |
2016年 | 4篇 |
2015年 | 4篇 |
2014年 | 11篇 |
2013年 | 8篇 |
2012年 | 11篇 |
2011年 | 11篇 |
2010年 | 11篇 |
2009年 | 6篇 |
2008年 | 9篇 |
2007年 | 5篇 |
2006年 | 17篇 |
2005年 | 6篇 |
2004年 | 6篇 |
2003年 | 8篇 |
2002年 | 1篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1985年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1968年 | 1篇 |
1967年 | 7篇 |
排序方式: 共有170条查询结果,搜索用时 15 毫秒
161.
162.
163.
A. N. Stroganov K. I. Afanasiev V. A. Burmensky L. A. Zhivotovsky N. V. Zuykova E. A. Kriksunov N. V. Mukhina M. P. Polyakov G. A. Rubtsova A. V. Semenova A. M. Shadrin O. Yu. Frolov 《Russian Journal of Marine Biology》2017,43(2):132-139
The mechanisms of the adaptation of the Kildin cod to the conditions of a meromictic lake were analyzed based on the study of morphological, biological, and genetic characteristics. Significant differences between the Kildin cod and Atlantic cod have been found in their morphological and genetic characteristics. The results of an X-ray microanalysis of otoliths, which were conducted for the first time, confirm that the distribution range of the Kildin cod in Lake Mogilnoye also extends to brackish waters. It has been shown that the formation of the reproductively isolated lacustrine population of Kildin cod is accompanied by specialization in a number of characteristics (body color, feeding strategy, behavior, etc.) and by a decrease in genetic diversity. 相似文献
164.
E. V. Rubtsova M. S. Kuyukina I. B. Ivshina 《Applied Biochemistry and Microbiology》2012,48(5):452-459
The effect of cultivation conditions (the composition, acidity, and salinity of the cultivation medium; temperature; and the hydrodynamic conditions of cultivation) on the adhesion of actinobacteria of the genus Rhodococcus to n-hexadecane has been investigated. A study performed showed that the adhesive activity of rhodococci depends on the composition of the cultivation medium and on the cultivation temperature. The possible mechanisms underlying the effect of growth conditions on the adhesion of rhodococci to liquid hydrocarbons and involving changes in the cell lipid content or the zeta potential of cells are addressed. Rhodococcal strains displaying high adhesive activity (80–90%) at a low temperature (18°C), high salinity (5.0% NaCl), and acidity (pH 6.0) of the cultivation medium have been selected as a result of the present work; these strains have a considerable potential for use in bioremediation of soil and water contaminated by hydrocarbons. 相似文献
165.
Sit‐and‐wait predators use relatively simple rules for their decisions to choose and leave a patch, such as using the direct presence of prey to select a hunting site. However, the direct presence of prey can only be used when there is a highly visited patch in the proximity of the predator. Therefore, it is plausible that sit‐and‐wait predators also exploit indirect cues of prey presence and, consequently, use associative learning to select a hunting site. The present study tests for the role of associative learning in a sit‐and‐wait predator species for which the ecology is well understood: Misumena vatia Clerck crab spiders. An ecologically relevant scenario is used by selecting flower colour as the conditioned stimulus and prey presence as the unconditioned stimulus. The results provide no evidence that M. vatia crab spiders use the association between flower colour and food presence for selecting a hunting site. After a training phase of being exposed to a colourful artificial flower highly visited by bees, spiders select a hunting site independently of its colour during the testing phase. Investigations of similar scope and ecological relevance are required with other sit‐and‐wait predators to identify the conditions promoting the use of associative learning for foraging site selection when animals face an unpredictable food supply. 相似文献
166.
V. G. Grigorenko M. Yu. Rubtsova I. V. Uporov I. V. Ishtubaev I. P. Andreeva D. S. Shcherbinin A. V. Veselovsky A. M. Egorov 《Biochemistry (Moscow) Supplemental Series B: Biomedical Chemistry》2018,12(2):87-95
Beta-lactamases (EC 3.5.2.6) represent a superfamily containing more than 2000 members: it includes genetically and functionally different bacterial enzymes capable to degrade the beta-lactam antibiotics. Beta-lactamases of molecular class A with serine residue in the active center are the most common ones. In the context of studies of the mechanisms underlying of evolution of the resistance, TEM type beta-lactamases are of particular interest due to their broad polymorphism. To date, more than 200 sequences of TEM type beta-lactamases have been described and more than 60 structures of different mutant forms of these enzymes have been presented in the Protein Data Bank. We have considered here the main structural features of the enzymes of this type with particular attention to the analysis of key mutations determining drug resistance and the secondary mutations, their location relative to the active center and the surface of the protein globule. We have developed a BlaSIDB database (www.blasidb.org) which is an open information resource combining available data on 3D structures, amino acid sequences and nomenclature of the TEM type beta-lactamases. 相似文献
167.
Biochemistry (Moscow) - Cell functioning is tightly regulated process. For many years, research in the fields of proteomics and functional genomics has been focused on the role of proteins in cell... 相似文献
168.
Zhivotovsky L. A. Podorozhnyuk E. V. Kulbachnyi S. E. Shitova M. V. Rakitskaya T. A. Nikiforov A. I. Rubtsova G. A. Afanasyev K. I. 《Journal of Ichthyology》2021,61(4):585-593
Journal of Ichthyology - Using the example of chum salmon Oncorhynchus keta in the Amur zoogeographic province, we review the principle of subdividing the species into population groups. On the... 相似文献
169.
D. S. Shcherbinin M. Yu. Rubtsova V. G. Grigorenko I. V. Uporov A. V. Veselovsky A. M. Egorov 《Biochemistry (Moscow) Supplemental Series B: Biomedical Chemistry》2017,11(2):120-127
Synthesis of β-lactamases is one of the common mechanisms of bacterial resistance to β-lactam antibiotics such as penicillins and cephalosporins. The widespread use of antibiotics resulted in appearance of numerous extended-spectrum β-lactamase variants or inhibitor-resistant β-lactamases. In TEM type β-lactamases mutations of 92 residues have been described. Several mutations are functionally important and they determine the extended substrate specificity. However, roles of the most so-called associated mutations, located far from the active site, remain unknown. We have investigated the role of associated mutations in structure of β-lactamase TEM-72, which contains two key mutations (G238S, E240K) and two associated mutations (Q39K, M182T) by means of molecular dynamics simulation. Appearance of the key mutations (in 238 and 240 positions) caused destabilization of the protein globule, characterized by increased mobility of amino acid residues. Associated mutations (Q39K, M182T) exhibited opposite effect on the protein structure. The mutation M182T stabilized, while the mutation Q39K destabilized the protein. It appears that the latter mutation promoted optimization of the conformational mobility of β-lactamase and may influence the enzyme activity. 相似文献
170.