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61.
Unusually high levels of acetylcholinesterase (AChE) were found in the nematode parasites Trichostrongylus axei, T. colubriformis and T, retortaeformis. In T. colubriformis the enzyme was located in the oesophageal and excretory glands of the parasitic stages. The highest level/unit wt was found in the fourth-stage larvae, which per worm had a comparable level to that in adult worms because the excretory gland was fully developed in the fourth-stage larvae. In acrylamide gel electrophoresis, T. axei and T. colubriformis AChE and esterases were similar but differed from those present in T. retortaeformis. Globulins prepared from the sera of sheep and guinea-pigs infected with T. colubriformis complexed with T. colubriformis and T. axei AChE, but not with esterases nor with AChE from T. retortaeformis, Nippostrongylus brasiliensis, Oesophagostomum radiatum or O. venulosum. Complexing of AChE to globulins did not inhibit the enzymic function of this enzyme. 相似文献
62.
Resting oxygen consumption (VO2) before and after injection of noradrenaline (NA), and plasma triiodothyronine levels were elevated in hyperthyroid and hyperphagic cafeteria fed rats, but were reduced in 4d-fasted and hypothyroid animals compared to controls. Refeeding fasted rats with a single carbohydrate meal caused all of these parameters to increase towards control levels. In vivo turnover, and in vitro release of NA brown adipose tissue (BAT) was elevated in cafeteria fed rats but remained unaltered in other groups and levels and uptake of NA in BAT were similar for all rats. Basal and NA stimulated Na+,K+-ATPase activity in BAT was increased in cafeteria and hyperthyroid rats and reduced in fasted and hypothyroid animals compared to control and refed groups. A highly significant correlation (r = 0.977), (P less than 0.001), found between the in vitro activity of this enzyme and resting VO2 in all rats, indicates that BAT Na+,K+-ATPase may be involved in the thermogenic responses to diet, catecholamines and thyroid hormones. 相似文献
63.
Comparison of the DNA sequence of the Crawford small-plaque variant of polyomavirus with those of polyomaviruses A2 and strain 3. 总被引:17,自引:5,他引:12
The DNA sequence of two wild-type strains of polyomavirus (A2 and strain 3) are known. We have determined the majority of the DNA sequence of a third strain, the Crawford small-plaque virus. This virus has been noted for its capacity to induce readily detected tumor-specific transplantation antigen in hamster cells, a property that is most likely attributable to an altered middle T-antigen. A comparison of its DNA sequence with those of the A2 and strain 3 viruses reveals numerous nucleotide substitutions, insertions, and deletions throughout the genome. Most sequence changes in coding regions are silent mutations; however, variability in proteins can be predicted from these sequence data at 5 locations in middle T-antigen, 10 in large T-antigen, and 10 in VP1. The Crawford small-plaque virus noncoding regulatory region contains, in addition to nucleotide substitutions, a 44-base-pair tandem repeat of sequences on the late side of the origin of DNA replication. 相似文献
64.
Permineralized stems, leaves and a fertile structure assignable to Cyathotheca Taylor are described from the Late Pennsylvanian Duquesne Coal of eastern Ohio. The new material, C. ventilaria sp. nov., provides the first evidence of vegetative structures for the genus. Vegetative parts are referred to the fertile fragments based upon distinctive vascular morphology, common histological features, and close association. Stems are up to 5.0 mm in diam and have an apparently endarch dictyostele with scalariform metaxylem tracheids. Secondary xylem consists of tracheids with bordered pitting and uniseriate, parenchymatous rays 1–9 cells high. Leaves are arranged in a 3/8 pattern. They are small, pinnately-lobed, and vascularized by an U-shaped bundle. Distal to divergence, one of the apparent leaf traces becomes radial to resemble the base of a fertile structure. This implies a mode of attachment for the fructification and suggests evidence to interpret its homologies. The fertile specimen consists of laminae that diverge from a short stalk, and bifurcate distally. Laminae bear sporangia 0.6–0.7 mm in diam attached adaxially by vascularized pedicels. Spores average 36 μm in diam and are of the Kewaneesporites type. The combination of features now known for Cyathotheca exclude it from assignment to a currently-recognized major group of vascular plants, thus emphasizing that the Pennsylvanian coal swamp flora included a greater diversity than commonly is interpreted. 相似文献
65.
A rhizomorph of Paurodendron with an intact apex recently has been discovered in Upper Pennsylvanian sediments of Ohio, and this provides the anatomical evidence necessary to interpret structure, ontogeny and homologies among lycophyte rooting organs. The basal meristem of Paurodendron is radial and lenticular, and produces an apical plug of parenchymatous tissue similar to a root cap. The plug is surrounded by a furrow associated with radially aligned cells that demonstrate a developmental correspondence to the furrow(s) of Isoetes. Based on external structural similarities at the rhizomorph apices of Paurodendron, Stigmaria, and young Nathorstiana, and on the anatomical similarities of Paurodendron to Isoetes, Stigmaria, Chaloneria, and Lepidocarpon embryos, all are interpreted as having a rooting organ that represents a modified shoot system that is fundamentally unlike the primary root system of seed plants. Likewise, the rootlets of rhizomorphic lycophytes are interpreted as leaves modified for rooting, and that have the equivalent of exogenous origin. As such, they are fundamentally unlike the adventitious roots of rhizomatous lycophytes like Lycopodium and Selaginella. 相似文献
66.
Trichostrongylus colubriformis infective larvae were subjected to various levels of γ-irradiation and administered to guinea pigs. The worms surviving were subsequently counted. Irradiation with 12.9 C kg− inhibited worm establishment but lower doses neither influenced worm establishment nor survival. 相似文献
67.
J T Rothwell P A Harper W J Hartley R C Gumbrell H R Meischke 《Journal of wildlife diseases》1990,26(2):275-278
A probable neurovisceral lysosomal storage disease is reported, for the first time, in immature red and grey kangaroos (Macropus rufus and M. giganteus). Foamy, pale eosinophilic, periodic acid-Schiff positive, intracytoplasmic material was stored in the liver, lymphoid tissue, kidney, adrenal gland, stomach, blood vessels and central nervous system. Extensive Wallerian-type degeneration was present in the central nervous system. Electron microscopic study of one animal revealed electron dense, cytoplasmic lamellar bodies in neurons and foamy visceral cells. The disease differs from other reported storage diseases in the distribution and nature of the lesions. 相似文献
68.
Fever and activation of acute phase responses were induced in human volunteers by intramuscular injection of typhoid vaccine. Vaccine injection caused a rapid (within 1 h) and sustained rise in metabolic rate (peak response 16%, 6-8 h), followed by later increases in white blood cell count (3-4 h), skin temperature (4-5 h), oral temperature (5-6 h), heart rate (6-8 h), and plasma cortisol (5-8 h). A peak fever [1.2 +/- 0.2 degree C (SE) rise] was recorded 12 h after vaccine injection. The involvement of the sympathetic nervous system in the development of these responses was investigated by the oral administration of propranolol before (80 mg) and 3 h after (40 mg) vaccine injection. Propranolol prevented the increases in metabolic rate, heart rate, and skin temperature but did not inhibit the rise in oral temperature or white cell count after vaccine administration. These data indicate that the sympathetic nervous system is responsible for the rise in energy expenditure associated with fever in humans. However, the rise in body temperature can develop in the absence of this increase in metabolic rate possibly by changes in heat loss. 相似文献
69.
Rothwell NJ Stock MJ 《Comparative biochemistry and physiology. A, Comparative physiology》1985,82(4):745-751
1. The structure, location, identification and thermogenic function of brown adipose tissue is discussed before describing its distribution in animals. 2. With a few interesting exceptions, brown fat occurs almost exclusively in mammals. 3. This tissue has been positively identified in thirteen orders, but more thorough investigations are required before its absence can be confirmed in the remaining eight mammalian orders. 4. Factors influencing the amount and activity of brown fat seen between and within species are numerous, but some of the most important are body size, diet, environmental temperature, age and reproductive state. 5. The role brown fat, and the effects of impairments in its function, are described in relation to thermoregulation and the control of energy balance and body composition. 相似文献
70.