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31.
The position of the virus particle in the crystallographic cell has been determined by application of the translation function and of residual calculations based on a hollow sphere model. 相似文献
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Structure determination of crystalline lobster D-glyceraldehyde-3-phosphate dehydrogenase 总被引:5,自引:0,他引:5
Single crystal X-ray data were collected on film for the holoenzyme of lobster d-glyceraldehyde-3-phosphate dehydrogenase to 3·0 Å resolution. Films of potassium tetraiodomercurate, K2HgI4, comprising a complete low resolution set, with some additional high resolution terms, were given to us by Drs H. C. Watson and L. J. Banaszak. A 3·0 Å high resolution data set was collected of a p-chloromercuri-phenylsulfonate derivative. All these films were processed on a computer controlled Optronics film scanner. The K2HgI4 derivative difference Patterson was initially interpreted in terms of four single sites, one for each polypeptide chain, consistent with the previously determined molecular 222 symmetry. Single isomorphous replacement phases were then sufficient to identify other heavy atom sites. Least-squares refined parameters were used to give multiple isomorphous replacement phases at low resolution, and single isomorphous replacement phases at high resolution. The resultant electron density map was oriented along the molecular 2-fold axes and then averaged over all four equivalent subunits. This process produced a much improved electron density map, which could easily be interpreted in terms of a single polypeptide chain per subunit consistent with the known amino acid sequence. The use of non-crystallographic symmetry to improve the electron density map is equivalent to the molecular replacement method. A comparison is also made with other dehydrogenases. 相似文献
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Comparison of super-secondary structures in proteins 总被引:36,自引:0,他引:36
A method of comparing the conformations of different, but structurally related proteins is described. Local variations, such as the systematic translation of a helix, or the position of deletions and insertions can be detected, and the correspondence of only marginally similar structures can be measured. The occurrence of larger continuous folds (“super-secondary structures”) has been detected in the comparison of lactate dehydrogenase with itself and with other protein structures. 相似文献
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Anastasia A Aksyuk Lidia P Kurochkina Mikhail M Shneider Victor A Kostyuchenko Vadim V Mesyanzhinov Michael G Rossmann 《The EMBO journal》2009,28(7):821-829
The contractile tail of bacteriophage T4 is a molecular machine that facilitates very high viral infection efficiency. Its major component is a tail sheath, which contracts during infection to less than half of its initial length. The sheath consists of 138 copies of the tail sheath protein, gene product (gp) 18, which surrounds the central non‐contractile tail tube. The contraction of the sheath drives the tail tube through the outer membrane, creating a channel for the viral genome delivery. A crystal structure of about three quarters of gp18 has been determined and was fitted into cryo‐electron microscopy reconstructions of the tail sheath before and after contraction. It was shown that during contraction, gp18 subunits slide over each other with no apparent change in their structure. 相似文献
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