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Rossana de Aguiar Cordeiro Ana Raquel Colares de Andrade Fernando Victor Monteiro Portela Lívia Maria Galdino Pereira Santiago Gonçalves Bezerra Moura Mônica Dantas Sampaio 《Biofouling》2020,36(5):610-620
AbstractThis study proposes a microcosm biofilm (MiB) model for the study of vulvovaginal candidiasis (VVC). Different conditions that mimic the vaginal environment were tested for MiB formation. The best growth conditions were obtained with samples incubated in vaginal fluid simulator medium pH 4.5 at 35?°C under a microaerophilic atmosphere. MiBs were evaluated for growth kinetics, fluconazole susceptibility and morphology. Samples containing high numbers of bacteria were analyzed for metagenomics. At 48?h, MiBs presented a higher cell density (CFU ml?1), a higher biomass and tolerance to fluconazole than their corresponding monospecies biofilms. Morphological analysis of MiBs revealed blastoconidia preferentially adhered to epithelial cells. Abundant Lactobacillus spp. were detected in two clinical samples; their MiBs showed a lower biomass and a higher fluconazole susceptibility. The proposed model proved to be a useful tool for the study of the complex microbial relationship in the vaginal environment, and may help to find new strategies for VVC control. 相似文献
443.
Glaucia A. Thompson‐Souza Giulia M. P. Santos Juliana C. Silva Valdirene S. Muniz Yasmim A. V. Braga Rodrigo T. Figueiredo Rossana C. N. Melo Andr L. S. Santos Marcia R. Pinto Josiane S. Neves 《Cellular microbiology》2020,22(7)
Neutrophils are leukocytes that are capable of eliminating both intra‐ and extracellular pathogens by mechanisms such as phagocytosis, degranulation, and release of neutrophil extracellular traps (NETs). Histoplasma capsulatum var. capsulatum (H. capsulatum) is a dimorphic fungus with a global distribution that causes histoplasmosis, a disease that is endemic in different geographic areas and is spreading worldwide. The release of NETs has been described as an important host defense mechanism against different fungi; however, there are no reports demonstrating that this process is implicated in neutrophil response to H. capsulatum infection. Therefore, the aim of this work is to investigate whether isolated human neutrophils release NETs in response to H. capsulatum and the potential mechanisms involved, as well as delineate the NETs antifungal activity. Using both confocal fluorescence and scanning electron microscopy techniques, we determined that NETs are released in vitro in response to H. capsulatum via an oxidative mechanism that is downstream of activation of the Syk and Src kinase pathways and is also dependent on CD18. NETs released in response to H. capsulatum yeasts involve the loss of neutrophil viability and are associated with elastase and citrullinated histones, however also can occur in a PAD4 histone citrullination independent pathway. This NETs also presented fungicidal activity against H. capsulatum yeasts. Our findings may contribute to the understanding of how neutrophils recognize and respond as immune effector cells to H. capsulatum, which may lead to better knowledge of histoplasmosis pathophysiology and treatment. 相似文献
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Benelli Jéssica Louise Basso Rossana Patrícia Grafulha Talita Werner Poester Vanice Rodrigues Munhoz Lívia Silveira Martins Katheryne Benine Zogbi Heruza Einsfeld Von Groll Andrea Severo Cecília Bittencourt Stevens David A. Xavier Melissa Orzechowski 《Mycopathologia》2022,187(4):397-404
Mycopathologia - Opportunistic infections are serious complications in critically ill COVID-19 patients, especially co-infections with bacterial and fungal agents. Here we report a rare case of... 相似文献
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de Lima-Neto Reginaldo Gonçalves Inácio Cícero Pinheiro Costa Ronyllton Brito de Aguiar Cordeiro Rossana Neves Wendell Wons Neves Rejane Pereira Magalhães Oliane Maria Correia Filho Armando Marsden Lacerda de Araújo Paulo Sergio Ramos 《Mycopathologia》2021,186(3):475-475
Mycopathologia - A correction to this paper has been published: https://doi.org/10.1007/s11046-021-00559-9 相似文献
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