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101.
Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH): a review
Tsutsui K Ubuka T Yin H Osugi T Ukena K Bentley GE Ciccone N Inoue K Chowdhury VS Sharp PJ Wingfield JC 《Journal of experimental zoology. Part A, Comparative experimental biology》2006,305(9):801-806
Neuropeptide control of gonadotropin secretion at the level of the anterior pituitary gland is primarily through the stimulatory action of the hypothalamic decapeptide, gonadotropin-releasing hormone (GnRH). However, a hypothalamic neuropeptide acting at the level of the pituitary to negatively regulate gonadotropin secretion has, until recently, remained unknown in any vertebrate. In 2000, we discovered a novel hypothalamic neuropeptide inhibiting gonadotropin release at the level of the pituitary in quail and termed it gonadotropin-inhibitory hormone (GnIH). A gonadotropin-inhibitory system is an intriguing concept and provides us with an unprecedented opportunity to study the regulation of avian reproduction from an entirely novel standpoint. To elucidate the mode of action of GnIH, we further identified the receptor for GnIH and characterized its expression and binding activity in quail. The identified GnIH receptor possessed seven transmembrane domains and specifically bound to GnIH in a concentration-dependent manner. The expression of GnIH receptor was found in the pituitary and several brain regions including the hypothalamus. These results suggest that GnIH acts directly on the pituitary via GnIH receptor to inhibit gonadotropin release. GnIH may also act on the hypothalamus to inhibit GnRH release. To understand the functional significance of GnIH in avian reproduction, we also investigated the mechanism that regulates GnIH expression. Interestingly, melatonin induced dose-dependently GnIH expression and melatonin receptor (Mel(1c)) was expressed in GnIH neurons. Thus melatonin appears to act directly on GnIH neurons via its receptor to induce GnIH expression. Based on these studies, GnIH is likely an important neuropeptide for the regulation of avian reproduction. 相似文献
102.
Andressa dos Santos Portas Danilo Ciccone Miguel Jenicer K. U. Yokoyama-Yasunaka Silvia Reni Bortolin Uliana Breno Pannia Espósito 《Journal of biological inorganic chemistry》2012,17(1):107-112
Copper complexes with fluorinated β-diketones were synthesized and characterized in terms of lipophilicity and peroxide-assisted
oxidation of dihydrorhodamine as an indicator of redox activity. The biological activity of the complexes was tested against
promastigotes of Leishmania amazonensis. Inhibition of trypanosomatid-specific trypanothione reductase was also tested. It was found that the highly lipophilic and
redox-active bis(trifluoroacetylacetonate) derivative had increased toxicity towards promastigotes. These results indicate
that it is possible to modulate the activity of metallodrugs based on redox-active metals through the appropriate choice of
lipophilic chelators in order to design new antileishmanials. Further work will be necessary to improve selectivity of these
compounds against the parasite. 相似文献
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Teixeira Fernanda Cardoso de Mattos Bruna da Silveira Mello Julia Eisenhardt de Cardoso Juliane Spohr Luiza Luduvico Karina Pereira Soares Mayara Sandrielly Pereira Carvalho Fabiano Barbosa Gutierres Jessie Martins Oliveira Campello Felix Anelize de Stefanello Francieli Moro Spanevello Roselia Maria 《Neurochemical research》2022,47(2):446-460
Neurochemical Research - This study investigated the effects of inosine on memory acquisition and consolidation, cholinesterases activities, redox status and Na+, K+-ATPase activity in a rat model... 相似文献
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G Palestro M Geuna D Novero L Godio G Ciccone L Azzoni 《Virchows Archiv. B, Cell pathology including molecular pathology》1990,59(5):297-304
The phenotype of the lymphoid cell component of 35 thymomas was investigated by analyzing cryostat sections and lymphocyte suspensions. The morphology in each case was determined by examining multiple tissue samples from different parts of the tumor. Structural heterogeneity was shown in 14 thymomas, and a homogeneous morphology of cortical or medullary or mixed types in the others. To assess whether this heterogeneity was correlated with differences in the lymphoid phenotype, we analyzed both lymphocyte suspensions and frozen sections from the same samples. Phenotypical differences in the suspensions of each thymoma in the heterogeneous group were noted and similar differences were also observed in the cryostat sections. Phenotypical abnormalities were found in some thymomas. They consisted of the simultaneous expression of cortical and medullary markers, which was most marked in the heterogenous mixed-type thymomas invading the lung. Furthermore, the global phenotype was tested on a pool of lymphocyte suspensions in all thymomas. This procedure distinguished cortical, medullary and intermediate cortico-medullary immunophenotype models which closely correlated with the tumor histology. It was concluded that, due to the frequent structural and immunological heterogeneity of thymomas, correct assessment of their lymphoid component requires a two-step analysis. This comprises: 1) individual suspensions from samples taken from different areas of the same thymoma, and 2) a pool of these suspensions. The first step will reveal the different immunological characteristics. In the second, the lymphocyte phenotype, which may vary widely throughout the tumor, will be represented in its totality. These findings may be of great help in predicting clinical patterns, especially possible malignant evolution. 相似文献