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排序方式: 共有392条查询结果,搜索用时 140 毫秒
101.
102.
Maitane Rodrigez Mendizbal Sonia Flamarique Andueza Isabel Quílez Sarda Maider Campo Gemma Asin Felipe Lombardo Rosas Gutierrez Andrea Barco Gomez Fernando Arias de la Vega 《Reports of Practical Oncology and Radiotherapy》2021,26(6):962
BackgroundThe objective of the study was to review the outcome of patients with parotid cancer treated with postoperative radiotherapy at Complejo Hospitalario de Navarra in the last ten years.Materials and methodsWe retrospectively reviewed patients treated with adjuvant radiotherapy between January 2008 and December 2018. We analyzed demographic data, histopathologic findings, local control (LC) and overall survival (OS).ResultsA total of 40 patients received postoperative radiotherapy during the period mentioned. There were 22 men (55%) and 18 women (45%). Median age was 58 years (19–90). By tumor histology, the most common was squamous cell carcinoma (22.5%) followed by ex-pleomorphic adenoma (15%) and adenoid cystic carcinoma (10%). According to Surgery, 19 patients (47.5%) underwent a total parotidectomy, 20 (50%) partial parotidectomy, and 1 (2.5%) a radical parotidectomy. Twenty-one patients (51.2%) underwent cervical dissection, most of them being supraomohyoid (31.7%). Reasons for adjuvant RT were: R1 resection (35% of the patients), high grade tumors (27.5%) and 17.5% because R1 surgery and R1. Radiation was administered using IMRT in most patients to a total dose of 60 Gy in 30 fractions. The 5-year overall survival (OS) (Kaplan-Meier) was 81% (95% CI: 68.5–96.2%), and 10-years — 64%. The 5-year local control (LC) (Kaplan-Meier) was 82.4% (95% CI: 91.46–73.33%) and the 10-year LC — 72.2% (95% CI: 54.9–96%). To date, only 4 patients (10%) have died due to their parotid tumor.ConclusionThe adjuvant radiotherapy added to surgery, significantly reduces the risk of recurrence in high-risk patients with a very acceptable survival rate. 相似文献
103.
104.
Urquiza M Lopez R Patiño H Rosas JE Patarroyo ME 《The Journal of biological chemistry》2005,280(42):35598-35605
Epstein-Barr virus (EBV) invasion of B-lymphocytes involves EBV gp350/220 binding to B-lymphocyte CR2. The anti-gp350 monoclonal antibody (mAb)-72A1 Fab inhibits this binding and therefore blocks EBV invasion of target cells. However, gp350/220 regions interacting with mAb 72A1 and involved in EBV invasion of target cells have not yet been identified. This work reports three gp350/220 regions, defined by peptide 11382, 11389, and 11416 sequences, that are involved in EBV binding to B-lymphocytes. Peptides 11382, 11389, and 11416 bound to CR2(+) but not to CR2(-) cells, inhibited EBV invasion of cord blood lymphocytes (CBLs), were recognized by mAb 72A1, and inhibited mAb 72A1 binding to EBV. Peptides 11382 and 11416 binding to peripheral blood lymphocytes (PBLs) induced interleukin-6 protein synthesis in these cells, this phenomenon being inhibited by mAb 72A1. The same behavior has been reported for gp350/220 binding to PBLs. Anti-peptide 11382, 11389, and 11416 antibodies inhibited EBV binding and EBV invasion of PBLs and CBLs. Peptide 11382, 11389, and 11416 sequences presented homology with the C3dg regions coming into contact with CR2 (C3dg and gp350 bound to similar CR2 regions). These peptides could be used in designing strategies against EBV infection. 相似文献
105.
Growth, metabolic rate, and digestive enzyme activity in the white shrimp Litopenaeus setiferus early postlarvae fed different diets 总被引:1,自引:0,他引:1
Brito R Chimal ME Gaxiola G Rosas C 《Journal of experimental marine biology and ecology》2000,255(1):21-36
Growth rate, soluble-protein content, oxygen consumption, ammonia excretion, and digestive-enzyme activity were studied in Litopenaeus setiferus early postlarvae under four feeding regimens that included combinations of freshly hatched Artemia nauplii, microparticulate commercial diet, and algae. Growth and of postlarvae fed a mixed diet were significantly higher. Artificial diet used alone caused the lowest growth, lowest soluble-protein content, higher ammonia excretion, lowest O:N ratio, and higher proteolytic and amylase activities. The artificial diet stimulated proteolytic activity and ammonia excretion of postlarvae, apparently in response to some deficiency in protein composition of the diet. Based on results in growth, soluble-protein content, enzymatic activity, and metabolic substrate, we determined that partial substitution of Artemia nauplii by artificial diet, with or without addition of algae when rearing early postlarval stages, will benefit the growth and nutritional state of L. setiferus postlarvae. 相似文献
106.
Abstract
The phylogenetic diversity of bacteria and cyanobacteria colonizing sediment particles in the permanent ice cover of an Antarctic
lake was characterized by analyses of 16S rRNA genes amplified from environmental DNA. Samples of mineral particles were collected
from a depth of 2.5 m in the 4-m-thick ice cover of Lake Bonney, McMurdo Dry Valleys, Antarctica. A rRNA gene clone library
of 198 clones was made and characterized by sequencing and oligonucleotide probe hybridization. The library was dominated
by representatives of the cyanobacteria, proteobacteria, and Planctomycetales, but also contained diverse clones representing
many other microbial groups, including the Acidobacterium/Holophaga division, the Green Non-Sulfur division, and the Actinobacteria. Six oligonucleotide probes were made for the most abundant
clades recovered in the library. To determine whether the ice microbial community might originate from wind dispersal of the
algal mats found elsewhere in Taylor Valley, the probes were hybridized to 16S rDNAs amplified from three samples of terrestrial
cyanobacterial mats collected at nearby sites, as well as to bacterial 16S rDNAs from the lake ice community. The results
demonstrate the presence of a diverse microbial community dominated by cyanobacteria in the lake ice, and also show that the
dominant members of the lake ice microbial community are found in terrestrial mats elsewhere in the area. The lake ice microbial
community appears to be dominated by organisms that are not uniquely adapted to the lake ice ecosystem, but instead are species
that originate elsewhere in the surrounding region and opportunistically colonize the unusual habitat provided by the sediments
suspended in lake ice.
Received: 16 August 1999; Accepted: 28 December 1999; Online Publication: 28 April 2000 相似文献
107.
108.
Lalueza-Fox C Sampietro ML Caramelli D Puder Y Lari M Calafell F Martínez-Maza C Bastir M Fortea J de la Rasilla M Bertranpetit J Rosas A 《Molecular biology and evolution》2005,22(4):1077-1081
Mitochondrial DNA (mtDNA) was retrieved for the first time from a Neandertal from the Iberian Peninsula, excavated from the El Sidrón Cave (Asturias, North of Spain), and dated to ca. 43,000 years ago. The sequence suggests that Iberian Neandertals were not genetically distinct from those of other regions. An estimate of effective population size indicates that the genetic history of the Neandertals was not shaped by an extreme population bottleneck associated with the glacial maximum of 130,000 years ago. A high level of polymorphism at sequence position 16258 reflects deeply rooted mtDNA lineages, with the time to the most recent common ancestor at ca. 250,000 years ago. This coincides with the full emergence of the "classical" Neandertal morphology and fits chronologically with a proposed speciation event of Homo neanderthalensis. 相似文献
109.
Embryonic-larval development, and metamorphosis larval time, were studied in the tropical fish Xenomelaniris brasiliensis. Twenty nine sexually mature specimens were used, 16 females (10.86+/-1.01 cm and 7.63+/-2.62 g) and 13 males (10.43+/-0.57 cm and 6.54+/-1.44 g) which produced gametes through abdominal massage. Fertilized eggs were spherical (1.18 +/-0.44 mm diameter), greenish, transparent, benthonic and vitelus-rich; rugose striated chorion with numerous external filaments randomly distributed and abundant oil globules (0.11 + 0.07 mm diameter). The embryonic development was finished at 26.36+/-2.03 degrees C, 39.67+/-0.58 PSU and pH 8.30+/-0.10. Larvae (4.56+/-0.97 mm total length) hatched at 143 hours and 19 minutes. with vitteline sac vestiges and a single oil globule. The larvae were fed on Brachionus plicatilis and Isochrysis galbana. After the second week .4rtemia nauplii were added and I. galbana maintained. Flexion started 13 days after larvae hatched (6.10+/-1.54 mm total length) and was completed 32 days later (11.25+/-1.87 mm total length) with the hipural complex completely developed. In conclusion, X brasiliensis showed direct larval development and started larval metamorphosis (13.08+/-2.07 mm total length) to juvenile 40 days after hatching. 相似文献
110.
A. Rosas 《Human Evolution》2000,15(1-2):83-98
The ontogenetic processes underlying the variation detected in the European Middle Pleistocene hominids are explored. Regulation
of growth parameters of the ontogenetic trajectory of these hominid is discussed in the context of heterochrony schemes. The
sample of mandibles coming from the Atauuerca-SH site is used as a study case. The variability shown by these mandibles can
be arranged along a morphological gradient, and study of growth directions has shown that the remodelling patterns are in
line with the existence of a single morphogenetic pattern controlling the process. In addition, the spectrum of morphology
detected in the Atapuerca sample virtually encompasses the entire range of variability detected in European Middle Pleistocene
samples. From a morphological viewpoint, a hypermorphic pattern seems to be the responsible for the individual variation detected
in the sample. Yet, when this information is related to mandibular growth and craniofacial interactions, evidence of an interindividual
gradient of somatic development for the Atapuerca hominids is provided. Several hypotheses concerning growth parameters, however,
may account for this gradient. Time and rate hypermorphosis hypothesis are discussed. Coincidence of the gradient of variation
detected in this sample and the general mandibular growth trajectory of living species, support the hypothesis that is “time
of maturation” of the organism the key factor. 相似文献