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301.
Rosalba Encarnación Lennart Kenne Gunnar Samuelsson Finn Sandberg 《Phytochemistry》1981,20(8):1939-1942
Four triterpenoid saponins isolated from the stem bark of Lecaniodiscus cupanioides and denoted S-2,S-3,S-4 and S-5, were identified as follows. S-2:3-O-[α-l-arabinopyranosyl-(1→3)-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranosyl]-hederagenin; S-3:3-O-[α-d-xylopyranosyl-(1→3)-α-l-rhamnopyranosyl-(1→2)-α-l-arabino-pyranosyl ]-hederagenin; S-4:3-O- [α-l-arabinopyranosyl-(1→3)-α-l-rhamnopyranosyl-(1→ 2)-α-l-arabinopyranosyl]-hederagenin; S-5:3-O- [α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranosyl ]-hederagenin. Of these, S-2 and S-4 are new substances. 相似文献
302.
Paolo Mondola Rosalba Seru Simona Damiano Mariarosaria Santillo 《Central European Journal of Biology》2007,2(3):337-350
The CuZn superoxide dismutase (SOD1), a member of a group of isoenzymes involved in the scavenger of superoxide anions, is
a dimeric carbohydrate free protein, mainly localized in the cytosol. The reactive oxygen species (ROS) are involved in many
pathophysiological events correlated with mutagenesis, cancer, degenerative processes and aging. In the first part of this
mini-review the well known role of SOD1 and ROS are briefly summarized. Following, a potential novel biological action that
SOD1 could exert is described, based on the recent researches demonstrating the secretion of this enzyme in many cellular
lines. Moreover, the role of impaired mutant SOD1 secretion, associated with cytoplasmic toxic inclusion, which occurs in
familial amyotrophic lateral sclerosis (ALS), is summarized. In addition, a depolarization-dependent release of SOD1 in pituitary
GH3 cells and in rat synaptosomes through a calcium and SNARE-dependent mechanism is reported. 相似文献
303.
Rosalba M. Farnesi Marinella Marinelli Simonetta Tei Daniela Vagnetti 《Journal of morphology》1982,173(2):237-245
The surface receptors in Branchiobdella pentodonta consist of “sense buttons” prevalent on the prostomium, isolated sense cells all along the body of the animal, and free nerve endings. The “sense buttons” are uni- and multiciliated neurosensitive elements and supporting cells together with mucus glandular processes and muscle fibers. In the neurosensitive elements the cilia are always surrounded by cytoplasmic extroversion. The cytoplasm of the apical zone has abundant small dense granules, mitochondria, bands of tonofilaments, and microtubules. The cilium of uniciliated elements originates from three short roots. The highly vacuolated support cells surround the neurosensitive elements, separating them from each other. The “sense buttons” appear to be mechanoreceptors and chemoreceptors, and the isolated sense cells tactile mechanoreceptors, as are the free nerve endings. The surface receptors are compared with those of other Oligochaeta and Hirudinea. 相似文献
304.
Rosalba Paesano Francesca Berlutti Miriam Pietropaoli Fabrizio Pantanella Enrica Pacifici William Goolsbee Piera Valenti 《Biometals》2010,23(3):411-417
Iron deficiency (ID) and iron deficiency anemia (IDA) are the most common iron disorders throughout the world. ID and IDA,
particularly caused by increased iron requirements during pregnancy, represent a high risk for preterm delivery, fetal growth
retardation, low birth weight, and inferior neonatal health. Oral administration of ferrous sulfate to cure ID and IDA in
pregnancy often fails to increase hematological parameters, causes adverse effects and increases inflammation. Recently, we
have demonstrated safety and efficacy of oral administration of 30% iron saturated bovine lactoferrin (bLf) in pregnant women
suffering from ID and IDA. Oral administration of bLf significantly increases the number of red blood cells, hemoglobin, total
serum iron and serum ferritin already after 30 days of the treatment. The increasing of hematological values by bLf is related
to the decrease of serum IL-6 and the increase of serum hepcidin, detected as prohepcidin, whereas ferrous sulfate increases
IL-6 and fails to increase hematological parameters and prohepcidin. bLf is a more effective and safer alternative than ferrous
sulfate for treating ID and IDA in pregnant women. 相似文献
305.
Alfredo Ferro Rosalba Giugno Giuseppe Pigola Alfredo Pulvirenti Cinzia Di Pietro Michele Purrello Marco Ragusa 《BMC bioinformatics》2007,8(1):58