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541.
9-Hydroxyellipticine (9-OHE), an inhibitor of microsomal monooxygenase activities has been shown to exert a large or even complete decrease of the mutagenicity, on the Salmonella strains of a great number of compounds (aromatic amines, polycyclic aromatic hydrocarbons, fungal toxins, azo compounds, tobacco smoke condensate). 9-OHE and 9-fluoroellipticine are more potent inhibitors than ellipticine itself. The inhibitions exerted by 9-OHE are not even equalled by 10-fold higher doses of 7,8-benzoflavone (7,8-BF). There is a good correlation between these data and the interaction properties of ellipticines with microsomal cytochromes P-450. 相似文献
542.
Various terrestrial tetrapods convergently evolved to gigantism (large body sizes and masses), the most extreme case being sauropod dinosaurs. Heavy weight-bearing taxa often show external morphological features related to this condition, but also adequacy in their limb bone inner structure: a spongiosa filling the medullary area and a rather thick cortex varying greatly in thickness along the shaft. However, the microanatomical variation in such taxa remains poorly known, especially between different limb elements. We highlight for the first time the three-dimensional microstructure of the six limb long bone types of a sauropod dinosaur, Nigersaurus taqueti. Sampling several specimens of different sizes, we explored within-bone, between-bones, and size-related variations. If a spongiosa fills the medullary area of all bones, the cortex is rather thin and varies only slightly in thickness along the shaft. Zeugopod bones appear more compact than stylopod ones, whereas no particular differences between serially homologous bones are found. Nigersaurus' pattern appears much less extreme than that in heavy terrestrial taxa such as rhinoceroses, but is partly similar to observations in elephants and in two-dimensional sauropod data. Thus, microanatomy may have not been the predominant feature for weight-bearing in sauropods. External features, such as columnarity (shared with elephants) and postcranial pneumaticity, may have played a major role for this function, thus relaxing pressures on microanatomy. Also, sauropods may have been lighter than expected for a given size. Our study calls for further three-dimensional investigations, eventually yielding a framework characterizing more precisely how sauropod gigantism may have been possible. 相似文献
543.
The ‘social bonding hypothesis'' predicts that, in large social groups, functions of gestural grooming should be partially transferred to vocal interactions. Hence, vocal exchanges would have evolved in primates to play the role of grooming-at-a-distance in order to facilitate the maintenance of social cohesion. However, there are few empirical studies testing this hypothesis. To address this point, we compared the rate of contact call exchanges between females in two captive groups of Japanese macaques as a function of female age, dominance rank, genetic relatedness and social affinity measured by spatial proximity and grooming interactions. We found a significant positive relationship between the time spent on grooming by two females and the frequency with which they exchanged calls. Our results conform to the predictions of the social bonding hypothesis, i.e. vocal exchanges can be interpreted as grooming-at-a-distance. 相似文献
544.
545.
Sônia Cristina Oliveira Melo Fernanda Amato Gaiotto Fernanda Barbosa Cupertino Ronan Xavier Corrêa Alessandra Maria Moreira Reis Dário Grattapaglia Rosana Pereira Vianello Brondani 《Conservation Genetics》2007,8(6):1269-1271
Caesalpinia echinata, commonly known as Pau-brasil (Brazilwood), the famous tree that named Brazil is native to the Atlantic forest. Men extensively
exploited it ever since discovery and colonial times due to its value as a source of red dye. As a consequence, Brazilwood
is a threatened species with populations reduced to small forest fragments. Ten polymorphic microsatellite loci were developed
from an enriched genomic library. Using fluorescently-labeled primers, a total of 83 alleles were found after analyzing a
sample of 44 trees. These high genetic information content markers should allow detailed investigations of mating systems,
gene flow, population structure and paternity in natural populations. 相似文献
546.
547.
Marcus Swann Neville Freeman Simon Carrington Gerry Ronan Paul Barrett 《International journal of peptide research and therapeutics》2003,10(5-6):487-494
Summary The use of Dual Polarisation Interferometry, and emerging analytical biophysical technique, is described for the determination
of the optogeometrical properties (thickness and density) at high resolution of adsorbed protein layers at the solid-liquid
interface. The technique has been used to quantify, in real time and at subatomic resolution, the structural changes occurring
in two well-characterised protein interaction systems, an antibody-antigen interaction and the biotin-streptavidin interaction.
The realtime data obtained on structural changes during the interactions is in excellent agreement with previously reported
X-ray crystallography and neutron reflection data. The precision of the measurements taken was of the order of 0.01 nm with
respect to protein size. The dual-parameter approach also allowed the stoichiometry of both of these interactions to be calculated,
giving values that confirm the current understanding of the interactions. This approach provides detailed insights into the
inherent and subtle link between structural change and function in proteins, to a degree not previously possible through mass
change measurements alone. The technique is expected to find utility in the increasingly important study of protein structure
and function. 相似文献
548.
P Lecointe J P Macquet J L Butour 《Biochemical and biophysical research communications》1979,90(1):209-213
There is a good correlation between the growth inhibitory properties of a series of Pt(II) derivatives on cultured L1210 mouse leukaemia cells and their efficiency of reversion to his+ of S. typhimurium TA100, or with their forward mutagenic effects on prophage λ. Reactivity towards DNA may thus explain the antitumor properties of these drugs. 相似文献
549.
Ronan Sulpice Agata Sienkiewicz-Porzucek Sonia Osorio Ina Krahnert Mark Stitt Alisdair R. Fernie Adriano Nunes-Nesi 《Amino acids》2010,39(4):1055-1066
Transgenic tomato (Solanum lycopersicum) plants were generated targeting the cytosolic NADP-dependent isocitrate dehydrogenase gene (SlICDH1) via the RNA interference approach. The resultant transformants displayed a relatively mild reduction in the expression
and activity of the target enzyme in the leaves. However, biochemical analyses revealed that the transgenic lines displayed
a considerable shift in metabolism, being characterized by decreases in the levels of the TCA cycle intermediates, total amino
acids, photosynthetic pigments, starch and NAD(P)H. The plants showed little change in photosynthesis with the exception of
a minor decrease in maximum photosynthetic efficiency (F
v/F
m), and a small decrease in growth compared to the wild type. These results reveal that even small changes in cytosolic NADP-dependent
isocitrate dehydrogenase activity lead to noticeable alterations in the activities of enzymes involved in primary nitrate
assimilation and in the synthesis of 2-oxoglutarate derived amino acids. These data are discussed within the context of current
models for the role of the various isoforms of isocitrate dehydrogenase within plant amino acid metabolism. 相似文献
550.
Paolacci Simona Bog Manuela Lautenschlager Ulrich Bonfield Ronan Appenroth Klaus-J. Oberprieler Christoph Jansen Marcel A.K. 《Biological invasions》2021,23(8):2649-2660
Biological Invasions - Invasive alien species can negatively impact on newly colonised ecosystems. Thus, it is important to understand factors that facilitate invasiveness. Genetic diversity will... 相似文献