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101.
102.
Placental malaria is hypothesized to lead to placental insufficiency, which causes fetal growth restriction (FGR). In this review, recent discoveries regarding the mechanisms of pathogenesis by which malaria causes FGR are discussed in the wider context of placental function and fetal growth. Placental malaria and associated host responses can induce changes in placental structure and function, affecting pregnancy-associated growth-regulating hormones and predisposing the offspring to hypertension and vascular dysfunction. Risk factors associated with FGR are highlighted, and potential interventions and studies to uncover remaining mechanisms of pathogenesis are proposed. Together, these strategies aim to decrease the burden of FGR associated with malaria in pregnancy. 相似文献
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104.
The growth of setae in post-division Chaeloceros gracilis Schütt was triphasic. Following cell separation there was an initial lag phase of about 30 min after which setae grew linearly at rates ranging from 0.20 to 0.38 μm-min?1. The growth rate was independent of whether diatoms cultured in medium containing 200 μM Si were transferred for experimentation to media containing 10 or 200 μM Si. When developing setae had attained a length of approximately 2 μm, their growth rate slowed as they entered a clearly defined plateau phase. The amount of silicon per unit length of setae was found to be 0.02 pg Si μm?1, and the deposition rate was estimated as 0.005 Pg Si min?1. Transmission electron microscopy revealed an axial structure resembling a microlubule extending the length of each seta and membrane bound polyphosphate bodies postulated to be the energy source for growth and associated biomineralization processes. 相似文献
105.
Are planktonic naked amoebae predominately floc associated or free in the water column? 总被引:1,自引:0,他引:1
Rogerson Andrew; Anderson O. Roger; Vogel Catherine 《Journal of plankton research》2003,25(11):1359-1365
The spatial distribution of planktonic naked amoebae in thewaters of a mangrove and estuarine habitat was investigated.Amoebae were grouped either as attached (whenon suspended flocs) or free (when floating inthe open water). Consistent with previous studies, amoebae werenumerically important in the water column. For example, in mangrovewater from south Florida, they averaged 94 640 cells l-1. Inthe mangrove, 91.6% of planktonic amoebae were attached to suspendedflocs. Likewise, the majority of amoebae in Hudson waters werefloc associated (86.7%). The results using a novel capture protocol,employing suspended capillary tubes to catch floating amoebae,suggested that free amoebae readily colonized available surfaces.Transmission electron microscopy demonstrated that amoebae werecapable of penetrating deep into the cracks and crevices offloc particles. The implications of these results are far reaching.For example, in the mangrove waters where the floc fractionin a liter of water accounted for 0.5 ml volume, the absolutedensity of amoebae at these loci was 173 380 amoebae per milliliterof floc material. Such high local abundance may have importanttrophic implications, particularly if amoebae, because of theirclose association with surfaces, graze attached bacteria unavailableto other micrograzers. The results presented here clearly showthat future studies on the microecology of flocs need to includeamoebae as well as the more widely investigated ciliates andheterotrophic flagellates. 相似文献
106.
Rowe JA Rogerson SJ Raza A Moulds JM Kazatchkine MD Marsh K Newbold CI Atkinson JP Miller LH 《Journal of immunology (Baltimore, Md. : 1950)》2000,165(11):6341-6346
The malaria parasite Plasmodium falciparum induces a number of novel adhesion properties in the erythrocytes that it infects. One of these properties, the ability of infected erythrocytes to bind uninfected erythrocytes to form rosettes, is associated with severe malaria and may play a direct role in the pathogenesis of disease. Previous work has shown that erythrocytes deficient in complement receptor (CR) 1 (CR1, CD35; C3b/C4b receptor) have greatly reduced rosetting capacity, indicating an essential role for CR1 in rosette formation. Using deletion mutants and mAbs, we have localized the region of CR1 required for the formation of P. falciparum rosettes to the area of long homologous repeat regions B and C that also acts as the binding site for the activated complement component C3b. This result raises the possibility that C3b could be an intermediary in rosetting, bridging between the infected erythrocyte and CR1. We were able to exclude this hypothesis, however, as parasites grown in C3-deficient human serum formed rosettes normally. We have also shown in this report that rosettes can be reversed by mAb J3B11 that recognizes the C3b binding site of CR1. This rosette-reversing activity was demonstrated in a range of laboratory-adapted parasite strains and field isolates from Kenya and Malawi. Thus, we have mapped the region of CR1 required for rosetting and demonstrated that the CR1-dependent rosetting mechanism occurs commonly in P. falciparum isolates, and could therefore be a potential target for future therapeutic interventions to treat severe malaria. 相似文献
107.
108.
Ilic MZ East CJ Rogerson FM Fosang AJ Handley CJ 《The Journal of biological chemistry》2007,282(52):37420-37428
Aggrecan loss from mouse cartilage is predominantly because of ADAMTS-5 activity; however, the relative contribution of other proteolytic and nonproteolytic processes to this loss is not clear. This is the first study to compare aggrecan loss with aggrecan processing in mice with single and double deletions of ADAMTS-4 and -5 activity (Deltacat). Cartilage explants harvested from single and double ADAMTS-4 and -5 Deltacat mice were cultured with or without interleukin (IL)-1alpha or retinoic acid and analyzed for (i) the kinetics of (35)S-labeled aggrecan loss, (ii) the pattern of (35)S-labeled aggrecan fragments released into the media and retained in the matrix, (iii) the pattern of total aggrecan fragments released into the media and retained in the matrix, and (iv) specific cleavage sites within the interglobular and chondroitin sulfate-2 domains. The loss of radiolabeled aggrecan from ADAMTS-4/-5 Deltacat cartilage was less than that from ADAMTS-4, ADAMTS-5, or wild-type cartilage under nonstimulated conditions. IL-1alpha and retinoic acid stimulated radiolabeled aggrecan loss from wild-type and ADAMTS-4 Deltacat cartilage, but there was little effect on ADAMTS-5 cartilage. Proteolysis of aggrecan contributed most to its loss in wild-type, ADAMTS-4, and ADAMTS-5 Deltacat cartilage explants. The pattern of proteolytic processing of aggrecan in these cultures was consistent with that occurring in cartilage pathologies. Retinoic acid, but not IL-1alpha, stimulated radiolabeled aggrecan loss from ADAMTS-4/-5 Deltacat cartilage explants. Even though there was a 300% increase in aggrecan loss from ADAMTS-4/-5 Deltacat cartilage stimulated with retinoic acid, the loss was not associated with aggrecanase cleavage but with the release of predominantly intact aggrecan consistent with the phenotype of the ADAMTS-4/-5 Deltacat mouse. Our results show that chondrocytes have additional mechanism for the turnover of aggrecan and that when proteolytic mechanisms are blocked by ablation of aggrecanase activity, nonproteolytic mechanisms compensate to maintain cartilage homeostasis. 相似文献
109.
Nectria atrofusca, a parasite ofStaphylea trifolia in eastern North America but extending as far west as Iowa, is redescribed. Its anamorph is described asFusarium staphyleae Samuels & Rogerson, sp. nov. 相似文献
110.
JB Griffin V Lokomba SH Landis JM Thorp AH Herring AK Tshefu SJ Rogerson SR Meshnick 《Malaria journal》2012,11(1):319
ABSTRACT: BACKGROUND: During early pregnancy, the placenta develops to meet the metabolic demands of the foetus. The objective of this analysis was to examine the effect of malaria parasitaemia prior to 20 weeks' gestation on subsequent changes in uterine and umbilical artery blood flow and intrauterine growth restriction. METHODS: Data were analysed from 548 antenatal visits after 20 weeks' gestation of 128 women, which included foetal biometric measures and interrogation of uterine and umbilical artery blood flow. Linear mixed effect models estimated the effect of early pregnancy malaria parasitaemia on uterine and umbilical artery resistance indices. Log-binomial models with generalized estimating equations estimated the effect of early pregnancy malaria parasitaemia on the risk of intrauterine growth restriction. RESULTS: There were differential effects of early pregnancy malaria parasitaemia on uterine artery resistance by nutritional status, with decreased uterine artery resistance among nourished women with early pregnancy malaria and increased uterine artery resistance among undernourished women with early pregnancy malaria. Among primigravidae, early pregnancy malaria parasitaemia decreased umbilical artery resistance in the late third trimester, likely reflecting adaptive villous angiogenesis. In fully adjusted models, primigravidae with early pregnancy malaria parasitaemia had 3.6 times the risk of subsequent intrauterine growth restriction (95% CI: 2.1, 6.2) compared to the referent group of multigravidae with no early pregnancy malaria parasitaemia. CONCLUSIONS: Early pregnancy malaria parasitaemia affects uterine and umbilical artery blood flow, possibly due to alterations in placentation and angiogenesis, respectively. Among primigravidae, early pregnancy malaria parasitaemia increases the risk of intrauterine growth restriction. The findings support the initiation of malaria parasitaemia prevention and control efforts earlier in pregnancy. 相似文献