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381.
382.
The effect of irradiance over the range 5 to 70 μmol photon m−2 s−1 on production of antibiotically active metabolites was assessed for male and female gametophytes and tetrasporophytes of
the red alga Sphyridia filamentosa (Wulfen) Harvey in Hooker in culture. Whole-algal extracts and ten recognizable TLC-separable
zones were assayed against five human microorganisms pathogenic to humans. For all experimental irradiance conditions, the
ten TLC zones displayed activity against four of the microorganisms. The maximum number of TLC zones with activity under any
of the culture conditions was six each for male and female Spyridia at 70 μmol photon m−2 s−1. Small changes in irradiance resulted both in different activities against specific microorganisms and degree of activity.
The fact that every TLC zone showed differing activities at different light conditions or when extracted from different life
history stages strongly suggests the presence of multiple antibiotic principals in individual TLC zones.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
383.
384.
V. Marchán L. Debéthune M. Beltrán J. Robles I. Travesset G. Fábregas 《Nucleosides, nucleotides & nucleic acids》2013,32(6-7):1493-1494
Abstract The preparation of nucleopeptides containing tryptophan and basic residues (lysine, arginine) is described. Different solid supports and the necessity of primary carboxamide protection have also been evaluated. 相似文献
385.
Patricia Basurto‐Lozada Christian Molina‐Aguilar Carolina Castaneda‐Garcia Martha Estefania Vzquez‐Cruz Omar Isaac Garcia‐Salinas Alethia lvarez‐Cano Hctor Martínez‐Said Rodrigo Roldn‐Marín David J. Adams Patricia A. Possik Carla Daniela Robles‐Espinoza 《Pigment cell & melanoma research》2021,34(1):59-71
Acral lentiginous melanoma is a histological subtype of cutaneous melanoma that occurs in the glabrous skin of the palms, soles and the nail unit. Although in some countries, particularly in Latin America, Africa and Asia, it represents the most frequently diagnosed subtype of the disease, it only represents a small proportion of melanoma cases in European‐descent populations, which is partially why it has not been studied to the same extent as other forms of melanoma. As a result, its unique genomic drivers remain comparatively poorly explored, as well as its causes, with current evidence supporting a UV‐independent path to tumorigenesis. In this review, we discuss current knowledge of the aetiology and diagnostic criteria of acral lentiginous melanoma, as well as its epidemiological and histopathological characteristics. We also describe what is known about the genomic landscape of this disease and review the available biological models to explore potential therapeutic targets. 相似文献