全文获取类型
收费全文 | 3188篇 |
免费 | 205篇 |
出版年
2023年 | 11篇 |
2022年 | 37篇 |
2021年 | 58篇 |
2020年 | 36篇 |
2019年 | 80篇 |
2018年 | 71篇 |
2017年 | 58篇 |
2016年 | 90篇 |
2015年 | 172篇 |
2014年 | 146篇 |
2013年 | 227篇 |
2012年 | 253篇 |
2011年 | 227篇 |
2010年 | 142篇 |
2009年 | 106篇 |
2008年 | 182篇 |
2007年 | 189篇 |
2006年 | 183篇 |
2005年 | 172篇 |
2004年 | 169篇 |
2003年 | 144篇 |
2002年 | 159篇 |
2001年 | 27篇 |
2000年 | 25篇 |
1999年 | 37篇 |
1998年 | 28篇 |
1997年 | 26篇 |
1996年 | 24篇 |
1995年 | 22篇 |
1994年 | 16篇 |
1993年 | 16篇 |
1992年 | 12篇 |
1991年 | 22篇 |
1990年 | 13篇 |
1989年 | 11篇 |
1988年 | 12篇 |
1987年 | 20篇 |
1986年 | 6篇 |
1985年 | 9篇 |
1984年 | 14篇 |
1983年 | 10篇 |
1982年 | 22篇 |
1981年 | 13篇 |
1980年 | 13篇 |
1979年 | 11篇 |
1978年 | 7篇 |
1977年 | 14篇 |
1976年 | 5篇 |
1975年 | 10篇 |
1971年 | 5篇 |
排序方式: 共有3393条查询结果,搜索用时 578 毫秒
61.
Ventura Luigi Gnetti Letizia Rossi Maurizio Tiseo Marcello Giordano Giovanna Corradi Massimo Silva Mario Milanese Gianluca Minari Roberta Leonetti Alessandro Cattadori Sara Ampollini Luca Carbognani Paolo Mozzoni Paola 《Molecular biology reports》2021,48(4):3485-3494
Molecular Biology Reports - Benign metastasizing leiomyoma (BML) is a rare disease characterized by extrauterine benign leiomyomatosis in patients with a previous or concomitant history of uterine... 相似文献
62.
Jian-Jun Jia Roni M Lahr Michael T Solgaard Bruno J Moraes Roberta Pointet An-Dao Yang Giovanna Celucci Tyson E Graber Huy-Dung Hoang Marius
R Niklaus Izabella A Pena Anne K Hollensen Ewan M Smith Malik Chaker-Margot Leonie Anton Christopher Dajadian Mark Livingstone Jaclyn Hearnden Xu-Dong Wang Yonghao Yu Timm Maier Christian K Damgaard Andrea J Berman Tommy Alain Bruno D Fonseca 《Nucleic acids research》2021,49(6):3461
63.
Roberta Bonfiglioli Patrizia Mussoni Francesca Graziosi Monica Calabrese Andrea Farioli Francesco Marinelli Francesco S. Violante 《Journal of electromyography and kinesiology》2013,23(1):252-259
To test whether the influence of manual activity should be considered when interpreting the results of nerve conduction study (NCS) of the upper limbs performed during work shifts, we evaluated the short-term effect of 90-min repetitive manual work on NCS parameters. Twenty-eight healthy volunteers underwent NCS of the dominant limb at the end of an interview (T0), after a 30-min rest in sitting position (T1) and after performing a standardized 90-min manual task (T2). The task was designed to simulate typical assembly and packing activities. No significant differences were observed for skin temperature (Ts) and NCS parameters between T0 and T1. Significantly (p < 0.001) higher Ts mean values were found at T2 as compared to the previous tests for both females and males. The regression analysis showed an association between temperature variation and nerve conduction velocity values for the median and ulnar nerve at T2 as compared to T1. In females, a reduction of the mean sensory nerve action potential (SNAP) amplitude at T2 was recorded, whereas an opposite trend was observed among males. Manual work is able to influence hand Ts and to modify NCS parameters. SNAP amplitudes changes suggest gender differences in peripheral nerve characteristics that deserve further investigation. 相似文献
64.
Clayton L. Camic Terry J. Housh Jorge M. Zuniga C. Russell Hendrix Haley C. Bergstrom Daniel A. Traylor Richard J. Schmidt Glen O. Johnson 《Journal of electromyography and kinesiology》2013,23(2):342-348
The purpose of the present study was to examine the patterns of responses for torque, electromyographic (EMG) amplitude, EMG mean power frequency (MPF), mechanomyographic (MMG) amplitude, and MMG MPF across 30 repeated maximal isometric (ISO) and concentric (CON) muscle actions of the leg extensors. Twelve female subjects (21.1 ± 1.4 yrs; 63.3 ± 7.4 kg) performed ISO and CON fatigue protocols with EMG and MMG signals recorded from the vastus lateralis. The relationships for torque, EMG amplitude, EMG MPF, MMG amplitude, and MMG MPF versus repetition number were examined using polynomial regression. The results indicated there were decreases (p < 0.05) across the ISO muscle actions for torque (r2 = 0.95), EMG amplitude (R2 = 0.44), EMG MPF (r2 = 0.62), and MMG MPF (r2 = 0.48), but no change in MMG amplitude (r2 = 0.07). In addition, there were decreases across the CON muscle actions for torque (R2 = 0.97), EMG amplitude (R2 = 0.46), EMG MPF (R2 = 0.86), MMG amplitude (R2 = 0.44), and MMG MPF (R2 = 0.80). Thus, the current findings suggested that the mechanisms of fatigue and motor control strategies used to modulate torque production were similar between maximal ISO and CON muscle actions. 相似文献
65.
66.
67.
This research is focused on the antioxidant properties of dietary components, in particular phenolics and carotenoids and the assessment of the contribution of the combined antioxidants to the total antioxidant activity (TAA) of tomato fruit. The aim of this study was to analyse the effects of processing on the antioxidant properties of tomato. The effects of three different methods of processing fresh tomatoes into tomato sauce were investigated with respect to the antioxidant properties of the fruit. Identification and quantification of the main carotenoids and flavonoids present in tomatoes was achieved by HPLC analysis and the effect on the concentration and availability of these compounds was investigated at different stages of the processing. The processing affected mainly naringenin causing a reduction in the concentration. Conversely, levels of chlorogenic acid were increased suggesting an improvement in availability of this compound to extraction. The concentration of all- trans -lycopene was also increased following processing. Less than 10% isomerisation of all- trans -lycopene to the cis form was detected for all the methods analysed. The effects of processing on the overall antioxidant activity support the theory of a general improvement in availability of individual antioxidants. For both hydrophilic and lipophilic extracts TAA values were increased. 相似文献
68.
Alessandra Vacca Roberta Montisci Pietro Garau Paolo Siotto Matteo Piga Alberto Cauli Massimo Ruscazio Luigi Meloni Sabino Iliceto Alessandro Mathieu 《Arthritis research & therapy》2013,15(1):R8
Introduction
Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome.Methods
Forty-one SSc patients, asymptomatic for coronary artery disease, were tested for coronary flow velocity reserve (CFR) by transthoracic-echo-Doppler with adenosine infusion (A-TTE) and for left ventricular wall motion abnormalities (WMA) by dobutamine stress echocardiography (DSE). Myocardial multi-detector computed tomography (MDCT) enabled the presence of epicardial stenosis, which could interfere with the accuracy of the tests, to be excluded. Patient survival rate was assessed over a 6.7- ± 3.5-year follow-up.Results
Nineteen out of 41 (46%) SSc patients had a reduced CFR (≤2.5) and in 16/41 (39%) a WMA was observed during DSE. Furthermore, 13/41 (32%) patients showed pathological CFR and WMA. An inverse correlation between wall motion score index (WMSI) during DSE and CFR value (r = -0.57, P <0.0001) was observed; in addition, CFR was significantly reduced (2.21 ± 0.38) in patients with WMA as compared to those without (2.94 ± 0.60) (P <0.0001). In 12 patients with abnormal DSE, MDCT was used to exclude macrovasculopathy. During a 6.7- ± 3.5-year follow-up seven patients with abnormal coronary functional tests died of disease-related causes, compared to only one patient with normal tests.Conclusions
A-TTE and DSE tests are useful tools to detect non-invasively pre-clinical microcirculation abnormalities in SSc patients; moreover, abnormal CFR and WMA might be related to a worse disease outcome suggesting a prognostic value of these tests, similar to other myocardial diseases. 相似文献69.
David R. Borcherding Nelsen L. Lentz Philip M. Weintraub Mark W. Dudley Roberta Secrest Philip R. Kastner 《Nucleosides, nucleotides & nucleic acids》2013,32(10):2175-2191
Abstract Three novel nucleosides 1, 2, and 3 were prepared that contained side chains at the 2-position of adenosine. Compound 1 was shown to be the most selective A2a receptor agonist reported to date having an A1/A2 ratio of 2400. In addition, compound 1 was shown to reduce blood pressure in rats and dogs with only minimal effects on heart rate. 相似文献
70.
Olga Adelfinskaya Weidong Wu V. Jo Davisson Donald E. Bergstrom 《Nucleosides, nucleotides & nucleic acids》2013,32(10-12):1919-1945
Two novel C-linked oxadiazole carboxamide nucleosides 5-(2′-deoxy-3′,5′-β-D-erythro-pentofuranosyl)-1,2,4-oxadiazole-5-carboxamide (1) and 5-(2′-deoxy-3′,5′-β-D-erythro-pentofuranosyl)-1,2,4-oxadiazole-3-carboxamide (2) were successfully synthesized and characterized by X-ray crystallography. The crystallographic analysis shows that both unnatural nucleoside analogs 1 and 2 adapt the C2′-endo (“south”) conformation. The orientation of the oxadiazole carboxamide nucleobase moiety was determined as anti (conformer A) and high anti (conformer B) in the case of the nucleoside analog 1 whereas the syn conformation is adapted by the unnatural nucleoside 2. Furthermore, nucleoside analogs 1 and 2 were converted with high efficiency to corresponding nucleoside triphosphates through the combination chemo-enzymatic approach. Oxadiazole carboxamide deoxyribonucleoside analogs represent valuable tools to study DNA polymerase recognition, fidelity of nucleotide incorporation, and extension. 相似文献