Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

1. Download : Download high-res image (138KB)
2. Download : Download full-size image

     

Neutrophil inhibition with L-selectin-directed MAb improves or worsens survival dependent on the route but not severity of infection in a rat sepsis model.

Both route and severity of infection may influence immunomodulator agents in sepsis. We studied the effect of each variable on HRL-3, an L-selectin-directed MAb that inhibits neutrophil function, in a rat sepsis model. Animals (n = 800) were randomized to be treated with either HRL-3 or placebo and to receive Escherichia coli either intravenously (IV) or intrabronchially (IB) in doses producing low or high mortality rates. Animals received antibiotics and were observed for 168 h. Route but not dose of E. coli altered the effects HRL-3 on mortality rate (mean hazards ratio +/- SE). With IV E. coli, compared with control, HRL-3 was beneficial and reduced the hazards ratio both early (0 to 6 h; -0.75 +/- 0.23) and late (6 to 168 h; -0.72 +/- 0.36) (P = 0.001 and 0.04, respectively, over all E. coli doses). In contrast, with IB E. coli HRL-3 reduced the hazards ratio early (-1.1 +/- 0.36) but worsened it late (0.87 +/- 0.23) (P = 0.002 for both effects over all E. coli doses) in patterns significantly different from IV E. coli (P < 0.0001). Compared with control, although HRL-3 did not alter lung neutrophil numbers or injury score at 6 or 168 h with IV E. coli (P = ns for all), it reduced both early and increased them late with IB E. coli (P 相似文献   

Spectroscopy and photophysics of flavin-related compounds: 3-benzyl-lumiflavin.

Molecular structure, spectroscopic and photophysical data for the singlet state of 3-benzyl-lumiflavin in different solvents are presented. Theoretical studies concerning singlet-singlet and triplet-triplet excitation energies were carried out using time-dependent density functional theory (TD-DFT) calculations. These predictions are in good agreement with the experimental results, which reflect the solvent interactions. All the observable singlet-singlet transitions have pi-pi* character. The title compound appears to be an efficient sensitizer of the production of singlet oxygen (phi(Delta)= 0.53). The crystal structure of 3-benzyl-lumiflavin is also presented, along with its solid-state photophysical data.     

Quantitative floral phenology at the landscape scale: Is a comparative spatio-temporal description of ‘‘flowering landscapes’’ possible?

Entomophilous flowers form the food resources for insect pollinators. Many pollinator species forage at the landscape scale and depend on floral resources that are highly variable in space and time. We present a general model approach in which the floral resources of plant communities are estimated by the floral phenology and the cover of entomophilous plant species. We applied this landscape model in a case study for three landscape sections (1.5–2.2 km²) with strongly differing land-use patterns. The comparison between a conservation area and two agricultural landscapes shows extreme differences in the quantities and in the course of floral resources.

In a stepwise simplification of the landscape model we tested the effects of input data with lower spatio-temporal resolution. Even if input data for floral phenology and vegetation have a low resolution, the landscape model allows a ranking of landscape-specific floral resource potentials. The results of the case study encourage the use of landscape models to estimate floral resource potentials. The assessment of floral resource potentials may help to define this essential landscape quality for evaluation in practical nature conservation.