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Michael J. Renan 《Bioscience reports》1986,6(9):819-825
In this study, the nucleotide sequences of the 3 untranslated regions (UTR) of the mouse and human c-fos genes, and the rat and human -actin genes were examined. It is shown (i) that the 3 UTR of c-fos is highly conserved between mouse and man, (ii) that multiple copies of a 12 bp element occur, in clusters, in the 3 UTR both of c-fos and of -actin. This conserved 12 bp element is analogous to the putative repressor binding site previously identified (Renan,Bioscience Reports,5 (1985), 739–753). These findings provide additional support for the proposal that regulatory signals are located in the 3 UTR's of certain genes. 相似文献
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Priscila L. Santos Renan G. Brito João Pedro S. C. F. Matos Jullyana S. S. Quintans Lucindo J. Quintans-Júnior 《Molecular neurobiology》2018,55(6):4560-4579
Pain treatment is still ineffective in many conditions and remains one of the greatest challenges of modern medicine. Historically, due to the incredible variety of pharmacologically promising natural products (NPs) and the chemical complexity of their compounds, scientists have explored their use as a source of treatment for diseases or symptomatology. Fos protein and its precursor, the gene c-Fos, have been the subject of study in relation to the pathophysiology of pain as a possible tool to aid in its understanding. More recently, it has become a useful tool in the study of NPs with analgesic profile. Thus, this systematic review aimed to investigate the analgesic effect of NPs and derivatives through changes in Fos protein or c-Fos expression in nervous system central. The search terms “analgesics,” “Fos,” and “drug effects” were used in the databases PubMed, MEDLINE, Scopus, and Embase. Forty-six articles were identified. Twenty-five articles investigated Fos expression in the spinal cord, 1 in dorsal root ganglion, 11 in brain areas, and 9 investigated the association between the spinal cord and brain areas. Although Fos protein expression has been used as a tool in the studies of the mechanism of action of pain in relation to NPs with analgesic activity, the associations between brain areas and the spinal cord—and the possible pathways involved—have not yet been fully elucidated and deserve further study. 相似文献
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Renan Janke Bosque Jente Ottenburghs Cecília Rodrigues Vieira Fabrícius Maia Chaves Bicalho Domingos 《Evolution; international journal of organic evolution》2020,74(11):2541-2543
Mimicry can directly affect the evolutionary history of models, mimics, and signal receivers. Mimics often use multimodal signaling to deceive receivers. Jamie et al. showed that brood parasitic birds display multimodal signaling of mimetic traits triggered by sexual and filial imprinting on host species. These resulting adaptations can interact with premating isolation barriers to strengthen reproductive isolation and potentially drive sympatric speciation. 相似文献
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Elisangela G. F. Morais Marcelo C. Picanço Robert W. Barreto Gerson A. Silva Shaiene C. Moreno Renan B. Queiroz 《BioControl》2010,55(5):685-694
Miconia calvescens (Melastomataceae) is an invasive alien tree in native forests on some Pacific islands and a potentially invasive species
in Australia. Searches for potential classical biocontrol agents have been undertaken for over a decade in the centre of origin
(Central and South America). Salbia lotanalis (Lepidoptera: Pyralidae) is a leaf roller which has been recognized as a promising classical biocontrol agent for M. calvescens. This paper presents the biology and an impact study of S. lotanalis on M. calvescens. Life table parameters showed that S. lotanalis has a high reproductive capacity, with up to six generations a year. Miconia calvescens seedlings attacked by S. lotanalis caterpillars had their growth rate significantly reduced. Seedlings subjected initially to a high level of defoliation (80%)
caused by caterpillars had leaf fall and a lower leaf area than controls after 210 days. Considering the high population growth
rate and significant impact on young plants, S. lotanalis appears to have a high potential for use as a classical biological control agent to be used against M. calvescens. 相似文献
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Cruz Kaliane Zaira Camacho Maximiano Almeida Felipe Astolpho Vale Ellen Moura Botini Nadia Vettorazzi Rosana Gobbi Santos Renan Carrari Santa-Catarina Claudete Silveira Vanildo 《Plant Cell, Tissue and Organ Culture》2022,150(3):527-541
Plant Cell, Tissue and Organ Culture (PCTOC) - Sour passion fruit (Passiflora edulis Sims) has economic and social relevance and is an alternative crop mainly for family farming agriculture. The... 相似文献
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Edilson Bezerra dos Santos Filho Karen Adami-Rodrigues Flaviana Jorge de Lima Renan Alfredo Machado Bantim Torsten Wappler Antônio Álamo Feitosa Saraiva 《Historical Biology》2019,31(7):926-937
The analysis of insect-plant interaction can be provide paleoecological and paleoenvironmental important data for understanding the co-evolution between plants and insects. Since the appearance of the first evidence of leaves damaged by insects, these organisms have evolved together. In the Araripe Basin, the Crato Formation stands out by having abundance and diversity of fossils species of plants and insects. In this work they are documented interaction records in specimens of ferns, gymnosperms and angiosperms, showing a wide variety of types of interactions. Here we analyze 56 fossil specimens from the collections of the Museum of Paleontology and the Laboratory of Paleontology of the Universidade Regional do Cariri. The types of damage identified in this study is insect galls, leaf margin feeding (herbivory), leaf mines, oviposition of insects and skeletonization, which are present in 19 specimens. This analysis in search for evidences of plant–insect interaction contributes with new interaction patterns for the Crato Formation. Although the low sample rate, the new registers for plant-insect association were compared to records from different cretaceous basins. This suggests new possibilities in the studies for ecological relations and coevolutionary plant-insect during the Cretaceous. In addition, a new type of damage is identified in a pteridophyte. 相似文献
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Pozzi R Rosa JC Eguchi R Oller do Nascimento CM Oyama LM Aguiar O Chaves MD Ribeiro DA 《Cell biochemistry and function》2010,28(8):632-636
The aim of this study was to investigate the effects of acute exercise on genomic damage in an animal model. Male adult Wistar rats were divided into the following groups: control and acute exercised (experimental). For this purpose, 15 animals were accustomed to running on a rodent treadmill for 15 min per day for 5 days (10–20 m min?1; 08 grade). After 4 days at rest, active animals ran on the treadmill (22 m min?1, 58 grade) till exhaustion. Cells from peripheral blood, liver, heart, and brain were collected after 0, 2, and 6 h after exercise. The results showed that acute exercise was able to induce genetic damage in peripheral blood cells after 2 and 6 h of exercise, whereas liver pointed out genetic damage for all periods evaluated. No genetic damage was induced either in brain or in heart cells. In conclusion, our results suggest that acute exercise could contribute to the genetic damage in peripheral blood and liver cells. It seems that liver is a sensitive organ to the genotoxic insult after acute exercise. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
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Goude R Renaud S Bonnassie S Bernard T Blanco C 《Applied and environmental microbiology》2004,70(11):6535-6541
Erwinia chrysanthemi is a phytopathogenic soil enterobacterium closely related to Escherichia coli. Both species respond to hyperosmotic pressure and to external added osmoprotectants in a similar way. Unexpectedly, the pools of endogenous osmolytes show different compositions. Instead of the commonly accumulated glutamate and trehalose, E. chrysanthemi strain 3937 promotes the accumulation of glutamine and alpha-glucosylglycerate, which is a new osmolyte for enterobacteria, together with glutamine. The amounts of the three osmolytes increased with medium osmolarity and were reduced when betaine was provided in the growth medium. Both glutamine and glutamate showed a high rate of turnover, whereas glucosylglycerate stayed stable. In addition, the balance between the osmolytes depended on the osmolality of the medium. Glucosylglycerate and glutamate were the major intracellular compounds in low salt concentrations, whereas glutamine predominated at higher concentrations. Interestingly, the ammonium content of the medium also influenced the pool of osmolytes. During bacterial growth with 1 mM ammonium in stressing conditions, more glucosylglycerate accumulated by far than the other organic solutes. Glucosylglycerate synthesis has been described in some halophilic archaea and bacteria but not as a dominant osmolyte, and its role as an osmolyte in Erwinia chrysanthemi 3937 shows that nonhalophilic bacteria can also use ionic osmolytes. 相似文献